DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1b and sema3b

DIOPT Version :10

Sequence 1:NP_611244.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster
Sequence 2:NP_001121818.1 Gene:sema3b / 567064 ZFINID:ZDB-GENE-081105-78 Length:775 Species:Danio rerio


Alignment Length:579 Identity:183/579 - (31%)
Similarity:279/579 - (48%) Gaps:66/579 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ILDHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALR 125
            :||.....:.|||::.:.::||:.: |:..::.|.:....||.|...||. ..||.||::|....
Zfish    59 LLDEERGRLFVGARNFLLSLSLDNISKQEQKIYWPAPVDWREECNWAGKDINTDCVNYVKVLHHY 123

  Fly   126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAF 190
            ....:..|||.::.|.|.:.        |.|.....|..|.:.|...:.:|..||.|.|.|....
Zfish   124 NRTHLYACGTGAFHPTCAYV--------EVGQKMEDHVFRIDPSLVEDGKGKSPYDPRHTSASVL 180

  Fly   191 ADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFF 243
            ....||:....|..|.|..|:|.     ::||||:|.:.||:|.|:.|.       ..:..|.||
Zfish   181 IGDELYAGVATDLMGRDFTIFRSMGQKPSIRTEQHDSRWLNEPKFIAAFGVPESDNPDDDKVFFF 245

  Fly   244 FRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FPFYFDEIQAI 306
            |||.::|...|||..|||:.::|:||.||..|....||:||||||.|||||.  ...:|||::.:
Zfish   246 FRETAVEAQGFGKVTYSRIGQLCRNDMGGQRSLVNKWTTFLKARLVCSVPGNDGTETHFDELRDV 310

  Fly   307 SPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPK 370
            ..:.....|: |||.|||||.:...|||||.:.::||..||.|.|..::.....|:|.: .:||.
Zfish   311 FLLQTRDKKNPLIYTVFTTSSSVFQGSAVCLYTMNDIRRAFLGPFAHKEGPNYQWIPFQ-GKVPY 374

  Fly   371 PRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQV 428
            ||||.|       .|.::......:.|.::||||...|..:.||||..:..:.:..|.|.| .:|
Zfish   375 PRPGMCPSKTFGSFESTKGFPDNVIQFARHHPLMFNPVTPLGGRPLFLRTGIPYTFTQITV-DRV 438

  Fly   429 KSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKN 493
            .:..| :|||::.|||.|.|.|.|::.....::|     .:::.|:.|....:.|..:.||:.:.
Zfish   439 NAADG-HYDVMFIGTDVGSVLKVISVPKGSWSNT-----ELLLEELHVFKDSSSIISMQISSKRQ 497

  Fly   494 SLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQTHEC-KNLATSQHKF-------GT 549
            .|.|.||..:|.||||.|| :...|..|...:||.||||  .|.| :.|..::.:|       |.
Zfish   498 QLYVGSDTGVVQVPLHRCSMYGKACAECCLARDPYCAWD--GHTCTRYLPNTKRRFRRQDVRNGD 560

  Fly   550 KTYLQSLNSTKK-------------AAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL 595
            ...|.|.:..|:             ::.|.|  :|:......|.::..:...|.||.:|
Zfish   561 PNALCSGDHQKQRVLEKRLYAVDGSSSFLEC--VPKSLQAQITWTYQKLPENPREEVRL 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1bNP_611244.1 Sema_1A 55..511 CDD:200498 157/471 (33%)
PSI 510..>537 CDD:214655 11/27 (41%)
sema3bNP_001121818.1 Sema 46..515 CDD:472829 157/471 (33%)
PSI 514..>550 CDD:214655 13/37 (35%)
Ig_Sema3 574..664 CDD:409455 8/46 (17%)
Ig strand A 574..579 CDD:409455 0/4 (0%)
Ig strand B 584..592 CDD:409455 2/9 (22%)
Ig strand C 598..604 CDD:409455 1/5 (20%)
Ig strand C' 606..609 CDD:409455 0/2 (0%)
Ig strand D 619..623 CDD:409455
Ig strand E 626..633 CDD:409455
Ig strand F 639..648 CDD:409455
Ig strand G 651..664 CDD:409455
Blue background indicates that the domain is not in the aligned region.

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