DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema4ga

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_001921423.3	Gene:	sema4ga / 563785	ZFINID:	ZDB-GENE-060503-381	Length:	863	Species:	Danio rerio

Alignment Length:	802	Identity:	212/802 - (26%)
Similarity:	347/802 - (43%)	Gaps:	169/802 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MILLITLSGLTIVAGWMPDVKPDLQ---TKQDKVL-------AHFIGNSTDY-FKILDHNDEFVL 72
            ::||..:|.:     |....||.|.   |.:..||       ..|.|.:.:| ..:|:.:.:.:.
Zfish    14 LLLLYVVSSV-----WGYPFKPPLDLDVTPRTTVLFKGLLGCRRFRGLTLNYSLLLLEEDADLLY 73

  Fly    73 VGAKDVIYNVSLNGL-KEIAR-LEWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCG 134
            |||:..::.:..:.: ..:|: ::|.::|...:.|..||| ::.:|.|::|......:..:..||
Zfish    74 VGARGALFALQASDVSSSLAQTIDWEASDDQMQQCWNKGKDNQTECFNHIRFLQRFNSTHLYTCG 138

  Fly   135 TNSYKPRCRHYTPVE--VSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYS 197
            |:::.|.|.:....|  :||.            :|..|:     .|||.|:...|....|..:|:
Zfish   139 THAFSPLCAYIDGREFKISSV------------FEEGRE-----KCPYDPSKGYTGLLIDQQMYT 186

  Fly   198 ATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFVG-AIERNGY---------VLFFFRELS 248
            |:..:|. ..|.|.|.:    |:||:...:.|.:.|||| |:.|...         :.|||.|.|
Zfish   187 ASQYEFR-SFPDIRRNSPNPILKTEEAPTQWLQEADFVGSALVRESLSSSAGDDDKIYFFFTEKS 250

  Fly   249 MEVM-NFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312
            .|:. .|..:..:|||||||.||||..:..|.|||||||||.||:| ::.|:|:.::::..:..|
Zfish   251 QELSPYFSHSRVARVARVCKRDRGGLLTLQKKWTSFLKARLVCSLP-DYEFHFNVLRSVFFLEGS 314

  Fly   313 GSK-SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEF-KSQKDSQSHWLPVEREQVPKPRPGQ 375
            .|: |..|.:|......:..||:|.::|.||..||||.: :|::||.|.|... ..:||:||||.
Zfish   315 SSQDSAFYGIFGLEWKNVKASAICQYSVSDIQWAFDGPYMESKEDSNSKWTQY-TGKVPEPRPGS 378

  Fly   376 CVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSL 431
            |:.|         |..|....::|::.||||...:.....||||.:.|:.:  |.|||| .|..|
Zfish   379 CITDQHRAKGINSSINLPDDVLHFVRRHPLMYRQILPQGQRPLLFRRNVDY--TKIAVH-TVTGL 440

  Fly   432 SGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLV 496
            .|..|.:::.|||:|.:.:.:.:        .|.|.  :|.|:|:.....|:..:|||..:.|:.
Zfish   441 DGQIYHILFIGTDEGWLQRAVKV--------EDHLH--IIEELQLFEEPQPVDSIVISKKQMSVY 495

  Fly   497 VVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNS--T 559
            |.|..|:|.:||..|:....|..|:..:||.||||  ..||.::.:...:......:|:.|.  .
Zfish   496 VGSPTSVVQLPLSTCTRYSSCFDCVMARDPFCAWD--GLECVDITSHNSRANLTQDIQNGNQGCD 558

  Fly   560 KKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQ----GNQPS----------- 609
            |..|.....|..|.....:.|..          |..|.||:.:.:    ||:..
Zfish   559 KSTADDQVLHRSRSVMAGDDVLL----------QCELSSNLATPEWTLNGNELKGYGLDSGFRVG 613

  Fly   610 ------LEQQPTGGDDFGLNKI-----------TLTSMDPDDIMPNLNDPQ-----------KST 646
                  :|.||....|:....|           :||......:.|.:...|           :|:
Zfish   614 TDGLLVIEAQPYQSGDYCCFAIENSVRVPVLIYSLTVRQELPVPPPVKPTQPRFTTEIYWTSQSS 678

  Fly   647 ASVDEIKYASTP---------------------------SFMLLTTIVFFTFLVGGIAGICCVKA 684
            .|..|..:..||                           .|:|...:::..|.:.|..|...::|
Zfish   679 QSDSEEDFDPTPMSPRFEFLSVRNMEAMYLSLITILGGLCFVLTVVLLYVGFCLQGRRGKYSLRA 743

  Fly   685 KSRL---MEAQMDESHRNHFGK 703
            :.:.   ||.:...||.|  ||
Zfish   744 EKKRGGNMELKTISSHCN--GK 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/487 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
sema4ga	XP_001921423.3	Sema_4G	51..508	CDD:200523	150/489 (31%)
		PSI	510..549	CDD:214655	11/40 (28%)
		Ig	568..650	CDD:299845	15/91 (16%)
		IG_like	569..638	CDD:214653	13/78 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910