DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema4c

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001121718.1	Gene:	sema4c / 561895	ZFINID:	ZDB-GENE-080303-16	Length:	863	Species:	Danio rerio

Alignment Length:	581	Identity:	175/581 - (30%)
Similarity:	268/581 - (46%)	Gaps:	87/581 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MILLITLSGLT--IVAGWMPDVKPDLQTKQDKV---LAHF----IGNSTDYFKILDHNDEFVLVG 74
            ::|:|.:.|..  |...|.|  .|....|.:.|   :|.|    :.|.|  ...|..::..:.||
Zfish     6 VLLVIFVIGFEKGICVNWNP--VPRKTVKYNDVHDSMARFRAVGVWNYT--MLTLAEHERVLYVG 66

  Fly    75 AKDVIYNVSLNGLKEIAR--LEWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTN 136
            |::.|:.:..|.:....|  :||.:....::.||.||| ::.:|.||:|......:..:..|||.
Zfish    67 ARENIFALDPNDISRQLRPQIEWSAPAEKKKECAAKGKNNQTECFNYIRFLQSYNHTHLYTCGTY 131

  Fly   137 SYKPRCR-----HYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLY 196
            :::|:|.     |:|....:.|                   :.:|.|||.||...|....|..||
Zfish   132 AFQPKCTYINADHFTLDSAALE-------------------DGKGKCPYDPAKGHTGLIVDKELY 177

  Fly   197 SATVADFSGGDPLIYRENLRTEQYDLKQ------LNQPDFVGAI----ERNG------YVLFFFR 245
            |||:.:|.|.:|:|.| ||..:.|.:|.      ||:|:|||:.    .||.      .:.|||.
Zfish   178 SATLNNFLGTEPVILR-NLGQQHYSMKSEYLPAWLNEPNFVGSALVRESRNSKDGDDDKIYFFFS 241

  Fly   246 ELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIV 310
            |.::|:........:|||||||.|.||..:..|.||:|.||||.||.| |....|:.::|:..:.
Zfish   242 ERAVELDCDSDLTVARVARVCKGDLGGTRTLQKKWTTFQKARLMCSFP-ERHITFNNLRAVFTLP 305

  Fly   311 ESGSKSL-IYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPG 374
            .:..::. .|.:|......:..||||.:.:.::...|||.:|..::|...| ......||.||||
Zfish   306 GADWRTTSFYGIFHAQWGDVDVSAVCQYQIGEVKNVFDGPYKEYRESSQRW-GRYTGTVPSPRPG 369

  Fly   375 QCV---------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKS 430
            .|:         ..|..|....:||.|.|||||....|   ||||....::  .|.:|| .:|.|
Zfish   370 ACITNFDRENGYNSSLQLPDATLNFAKKHPLMELRAEA---RPLLLTKGIN--FTRLAV-DRVSS 428

  Fly   431 LSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSL 495
            |....|::::.||.||.:.:.: ||.:..:         ||.|:|:.....|:..|.||.||..|
Zfish   429 LDQRSYNMLFIGTADGWLQRVV-ILGSEAH---------VIEEIQLFDRQQPVDSLTISHSKKYL 483

  Fly   496 VVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSL 556
            .:.|...::.:||.:||.......||..:||.||||.:...|..:  ..|:..|.|..|.|
Zfish   484 YIGSRSEVLQLPLANCSRYHSQPDCLLSRDPYCAWDSEGRACVRI--DLHRGSTSTLSQDL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	148/489 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/26 (38%)
sema4c	NP_001121718.1	Sema_4C	40..497	CDD:200519	149/496 (30%)
		PSI	498..541	CDD:279745	14/44 (32%)
		Ig	569..656	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910