DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema6dl

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_005173705.1	Gene:	sema6dl / 550377	ZFINID:	ZDB-GENE-050417-171	Length:	1070	Species:	Danio rerio

Alignment Length:	830	Identity:	263/830 - (31%)
Similarity:	379/830 - (45%)	Gaps:	173/830 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHFI-----------GNSTDY---FKILDHNDE 69
            :|||:..|.|..|:      .|:.....|.|..|:.           ||.:.:   |:::....:
Zfish    11 LILLLVASRLDAVS------FPEDNIPLDVVDRHYARQYPVFRGRPSGNESQHRLDFQLMTQIHD 69

  Fly    70 FVLVGAKDVIYNVSL-----NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGE 129
            .:.:..:|.:|.|||     |.:....:|.|.|..||||.||:||||..:|||:::|...|.:..
Zfish    70 TLFIAGRDQVYLVSLRESYRNEIIPYRKLTWRSGQADRETCAMKGKHRDECHNFIKVLVPRNDDL 134

  Fly   130 VLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFAD 192
            |.:||||.:.|.||:|  ..:|...||                 :.....||:.....:...|||
Zfish   135 VFICGTNGFNPMCRYYRLDNLEFDGEE-----------------ISGLARCPFDAKQTNVALFAD 182

  Fly   193 GHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVM 252
            |.|||||||||...|.:|||     ..|||.:||.|.|.:|.|:.|::...:|.|||||::.|..
Zfish   183 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWLKEPHFLHAVDYGDFVYFFFREIAAEHN 247

  Fly   253 NFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKS 316
            |.||||||||||:||||.||... ..|.||||:|||||||||||..||||.:|||:.|::.....
Zfish   248 NLGKAVYSRVARICKNDMGGSQRVLEKHWTSFVKARLNCSVPGESFFYFDVLQAITDIIDINGVP 312

  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQC----- 376
            .:..||||.:|:|||||||||::.||..||.|.||.||...|.|.|...|::||||||.|
Zfish   313 SVVGVFTTQLNSIPGSAVCAFSMVDIEKAFRGRFKEQKTPDSVWTPFPEEKLPKPRPGCCAGHGS 377

  Fly   377 VEDSRTLTSI---AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY--Y 436
            .|..:|....   .:.|||:||||:.:||::...|..||..:.:||||:|    |.:.:|.:  |
Zfish   378 AESYKTSIEFPDETLQFIKSHPLMDASVPSIGDEPWFTKTRVRYRLTALA----VDNTAGPHKNY 438

  Fly   437 DVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQV------LPLGTPIRELV---ISTSK 492
            .|::.|::.|.|.|.  :..|.|.|..|   :|::.|:.|      |......|.::   :....
Zfish   439 TVVFIGSEAGIVLKV--LAKTSPLSLND---SVLLEEIDVFNQAKCLSSNEDDRRILSFHLDKDS 498

  Fly   493 NSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTH-ECKNL-ATSQH------KFG 548
            ::|.|.....:|.:||..|.....| ..|::.:||.|.|  .:| .|:.: ||.|.      ::|
Zfish   499 HTLYVAFSSCVVRIPLSRCERHSSCQKSCIASRDPYCGW--MSHGACERIPATMQSGYEQDVEYG 561

  Fly   549 TKTYL----QSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQP- 608
            ...:|    :.|.:|             .||..::..      .||.:.:|..|:|.....::|
Zfish   562 NTAHLGDCHEFLATT-------------SAPDFKSYG------DPTSDMELPSSSVTVPATSEPI 607

  Fly   609 -SLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTA---------SVDEIKYASTPSFM-- 661
             |.:..||              ..|....|: .||..|.:         .|.||:...:...:
Zfish   608 QSPQTNPT--------------QTPQLFEPH-GDPATSHSVEHIPGVLEGVWEIQAGESNQMVHM 657

  Fly   662 -LLTTIVFFTFLVGG-IAG--ICCV---------KAKSRLMEAQMDESHRNHFGKPMQFKHQNTG 713
             :|.:.|...||:|. |||  :.|.         |.:.....||........|.|
Zfish   658 NILISCVLAAFLLGAFIAGMVVYCYRDAFLRTPRKIQKDAESAQSCTDSTGSFAK---------- 712

  Fly   714 KDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLEKELPCKTSTLT 763
              :|.|..|   ...:..||||..|..::...|.     :|:|....|.|
Zfish   713 --LNGLFDS---PVKEYQPNLDTPKLYTNLLSNG-----REVPTTGETKT 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	191/490 (39%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/28 (29%)
sema6dl	XP_005173705.1	Sema	51..515	CDD:301699	190/489 (39%)
sema6dl	XP_005173705.1	PSI	516..570	CDD:279745	14/55 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1228
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm6502
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17321
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.990