Protein Alignment Sema1b and SEMA4C

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: XP_016859882.1
• Gene: SEMA4C / 54910
• HGNCID: 10731
• Length: 875
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 196/680 - (28%)
• Similarity: 297/680 - (43%)
• Gaps: 130/680 - (19%)

  Fly     4 KSRPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKP-------DLQTKQDKVLAHFIGNSTDYF 61
            |.|..:.||..:....:|...|.||.|.|....::.|       :|.|    |:..|.......|
Human    35 KLRAGACAMAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELAT----VVRRFSQTGIQDF 95

  Fly    62 KILDHNDE--FVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYA 123
            ..|...:.  .:.|||::.::..|:..|:....:.|.:....:..|..||| ::.:|.|::|...
Human    96 LTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQ 160

  Fly   124 LRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188
            ......:.:|||.:::|:|.:...:..:.|..         .:|     :.:|.|||.||.....
Human   161 PYNASHLYVCGTYAFQPKCTYVNMLTFTLEHG---------EFE-----DGKGKCPYDPAKGHAG 211

  Fly   189 AFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAI---ERNG------- 238
            ...||.|||||:.:|.|.:|:|.|     .:::|| |....||:|.|||:.   |..|
Human   212 LLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGDDD 275

  Fly   239 YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEI 303
            .|.|||||.::|...:.:.|.:|||||||.|.||..:..:.||:||||||.||.| .:..||:::
Human   276 KVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP-NWQLYFNQL 339

  Fly   304 QAISPIVE-SGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVER-- 365
            ||:..:.: |...:..:.||......:..||:|.:.:::|...|:|.:|...:....|   :|
Human   340 QAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKW---DRYT 401

  Fly   366 EQVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTK--VNLHHRL 419
            :.||.||||.|:.:         |..|....:||:|.||||||.|.....||||.|  .|..|
Human   402 DPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTH-- 464

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILS-THPNSTVDRLKTVVISEMQVLPLGTPI 483
               .|..:|..|.||.|.|::.||.||.:.|.:::.. .|           :|.|:|:.. ..|:
Human   465 ---LVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVH-----------LIEELQLFD-QEPM 514

  Fly   484 RELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHEC------KNLAT 542
            |.||:|.||..|...|...||.:|:..|.....|..|:..:||.|||.:.|..|      .....
Human   515 RSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLL 579

  Fly   543 SQHKFGTKTY-LQSLNSTKK------------AAALLCP-HIP------------RDAPGAETVS 581
            .||...:.|. :.:|..:||            ...|:.| |:.            ||.|..:..|
Human   580 IQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGS 644

  Fly   582 F---------VTMAPPP---------TEEQ 593
            |         |.||..|         :|||
Human   645 FLYDARLQALVVMAAQPRHAGAYHCFSEEQ 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/488 (31%)
		PSI	510..>537	CDD:214655	9/26 (35%)
SEMA4C	XP_016859882.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910