DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema3gb

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_005167089.1	Gene:	sema3gb / 544660	ZFINID:	ZDB-GENE-050513-4	Length:	746	Species:	Danio rerio

Alignment Length:	530	Identity:	175/530 - (33%)
Similarity:	263/530 - (49%)	Gaps:	69/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LQTKQDKVLAHFIGNSTDYFKIL--DHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRE 103
            |:||..:..: |..|::|| :||  |.:...:.:|:::.:.::.:..: ||...:.|.:|...:.
Zfish    34 LETKTIRPFS-FSFNTSDY-RILHMDQDQGRLYLGSREYLVSLDMQNVNKEPLIIHWPATTQRKG 96

  Fly   104 LCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYE 167
            .|.|.|| .:.:|.|::|:........:..|||.:|||.|...        ..|.....:..|..
Zfish    97 ECKLTGKGGQGECANFVRLIEPWNRTHLYTCGTGAYKPICTFI--------NRGWRAEEYLFRLV 153

  Fly   168 VSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIY-----RENLRTEQYDLKQLNQ 227
            .......:|..||.|...:..|..:|:|||....||.|.||.|:     |..:||||||.:.||:
Zfish   154 PGYVDSGKGKSPYDPRQENAAALINGNLYSGVHVDFMGTDPAIFRTLGDRPAVRTEQYDSRWLNE 218

  Fly   228 PDFV------GAIERNGYVL-FFFRELSMEVMNFGKA--VYSRVARVCKNDRGGPYSHGKSWTSF 283
            |.|:      .:.|:|...| |||||.|::... |.|  |.:||.|||.||.||..|....||:|
Zfish   219 PVFIKIQKIPDSAEKNDDKLYFFFREKSLDASG-GSAPSVLARVGRVCLNDDGGQRSLVNKWTTF 282

  Fly   284 LKARLNCSVPGE--FPFYFDEIQAI---------SPIVESGSKSLIYAVFTTSVNAIPGSAVCAF 337
            |||||.|||.|.  ...||||::.:         :|||        ||||:|:.:...|||||.:
Zfish   283 LKARLVCSVIGADGVETYFDELRDVFIQRTHDERNPIV--------YAVFSTAGSVFKGSAVCVY 339

  Fly   338 NVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQC--------VEDSRTLTSIAVNFIKNH 394
            ::.||...|:|.|..:......|.|. ..::|.||||.|        :..::..:..||||::.|
Zfish   340 SMSDIRNVFNGPFSHKHGHNYQWTPY-TGKIPYPRPGTCPGGTFTPDLHTTKAFSDEAVNFVRAH 403

  Fly   395 PLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHP 459
            |||.:.:..:|.|||:.:..:.:|.|.||| ..|.::.|. |:|::.|||.|.|.|.|.:    |
Zfish   404 PLMYQPIYPIHKRPLVVRTGVDYRFTTIAV-DLVDAVDGR-YEVLFLGTDRGTVQKVIVL----P 462

  Fly   460 N--STVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCL 521
            .  ||.:.|   ::.|::|......::.|.|||.:..|.|.|:..|..|.||.|: :...|..|.
Zfish   463 KDISTTEEL---ILEEVEVFKTPAAVKTLKISTKRQQLYVSSERGLTQVSLHRCAVYGKACSDCC 524

  Fly   522 SLQDPICAWD 531
            ..:||.||||
Zfish   525 LARDPYCAWD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	162/494 (33%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/23 (39%)
sema3gb	XP_005167089.1	Sema_3F	42..513	CDD:200515	163/499 (33%)
		PSI	512..558	CDD:214655	9/23 (39%)
		Ig_Semaphorin_classIII	576..662	CDD:143279
		IG_like	581..651	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910