DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema4g

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001101996.1	Gene:	Sema4g / 361764	RGDID:	1310436	Length:	837	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	199/747 - (26%)
Similarity:	319/747 - (42%)	Gaps:	129/747 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DVKPDLQTKQDKV--LAHFIGNSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGL-----KEIARL 93
            |..|.:....:::  :.||.|.:.:|.. :|:...:.:||||:..::::|...:     |||
  Rat    31 DATPRMTISYEELSWIRHFKGQAQNYSTLLLEEASQRLLVGARGALFSLSARDIGDGTHKEI--- 92

  Fly    94 EWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGS 157
            .|.::...:..|..||| ::.:|.|::|............|||::::|.|              :
  Rat    93 HWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNASHFYACGTHAFQPLC--------------A 143

  Fly   158 AGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR----ENLRTE 218
            |..|.|.....|.: |.:..|||.||...|....||.||:||..:|. ..|.|.|    .:||||
  Rat   144 AIDAEAFILPTSFE-EGKEKCPYDPARGFTGLIIDGGLYTATRYEFR-SIPDIRRSRHPHSLRTE 206

  Fly   219 QYDLKQLNQPDFV----------GAIERNGYVLFFFRELSMEVMNFGKAVYS----RVARVCKND 269
            :..:..||..:||          ..:..:..:.:||.|......:|.::..|    |||||||.|
  Rat   207 EAPMHWLNDAEFVFSVLVRESKTSVVGDDDKIYYFFMEREEGSSSFTQSRSSHRVARVARVCKGD 271

  Fly   270 RGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPI-VESGSKSLIYAVF--TTSVNAIPG 331
            .||.....|.|||||||||.|.:|     .::.::.:..: .::.|.:..||||  ||....:..
  Rat   272 LGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSLDADTSSHTHFYAVFTLTTQWKTLEA 331

  Fly   332 SAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVED---------SRTLTSIA 387
            ||:|.:::.:|.|.|.|.|...:|....|...| ..||:||||.|:.|         |:.|.|:.
  Rat   332 SAICRYDLAEIQAVFTGPFMEYQDGARRWGRYE-GGVPEPRPGSCITDSLRSRGYNSSQDLPSLV 395

  Fly   388 VNFIKNHPLMEEAVPAVHGRPLLTKVNLHH-RLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKF 451
            ::|:|.||||...|....|||||.|.|:.: .||  ..|..:.  :|..||:::.||.||.:.|.
  Rat   396 LDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHLT--GTHVSIP--AGPTYDLLFLGTADGWIHKA 456

  Fly   452 INILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVD 516
            : :|.:..:         :|.|:||......:..||||..::||.|.:...::..||..||....
  Rat   457 V-VLGSGMH---------IIEEIQVFRESQSVDNLVISPMQHSLYVGAASGVIQFPLSSCSRYRS 511

  Fly   517 CLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVS 581
            |..|:..:||.|.||..||.|....|..::                 ..|...|.|...|.|. |
  Rat   512 CYDCILARDPYCGWDSSTHACMVATTIANR-----------------TALIQDIERGNRGCEG-S 558

  Fly   582 FVTMAPPPTEEQKLLYSNVGSSQGNQPS-----------LEQQPTGGDDF--GLNKITLTSMDPD 633
            .....|||.:.:.:|..:......:|||           .:....|.|.:  |::.:.:|....:
  Rat   559 RDAGPPPPFKTRSVLRGDDVLLPCDQPSNLARALWLLNGSKSLSDGQDGYRVGVDGLLVTDTQLE 623

  Fly   634 -----DIMPNLNDPQKSTASVDEI----------KYASTPSFMLLTTI-VFFTFLVGGIAGICCV 682
                 ......|..:...||...|          :..:||...|...: :|:...:..:.|:|.:
  Rat   624 HSGNYGCYAEENGLRMLLASYSLIVRPATPAPAPQAPATPGAQLAHDMRLFYVVAIAILGGLCLI 688

  Fly   683 KAKSRLMEAQMDESHRNHFGKPMQFKHQNTGK 714
            .|.|.|..|.:....|   |:..::.....|:
  Rat   689 LASSLLYVACLRGGRR---GRRRKYSLGRAGR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	148/493 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
Sema4g	NP_001101996.1	Sema	47..504	CDD:301699	149/495 (30%)
		PSI	505..>533	CDD:279745	11/27 (41%)
		Ig_Sema4B_like	565..648	CDD:143280	13/82 (16%)
		IG_like	571..648	CDD:214653	11/76 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910