Protein Alignment Sema1b and Sema4g

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_001101996.1
• Gene: Sema4g / 361764
• RGDID: 1310436
• Length: 837
• Species: Rattus norvegicus
• Alignment Length: 747
• Identity: 199/747 - (26%)
• Similarity: 319/747 - (42%)
• Gaps: 129/747 - (17%)

  Fly    37 DVKPDLQTKQDKV--LAHFIGNSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGL-----KEIARL 93
            |..|.:....:::  :.||.|.:.:|.. :|:...:.:||||:..::::|...:     |||
  Rat    31 DATPRMTISYEELSWIRHFKGQAQNYSTLLLEEASQRLLVGARGALFSLSARDIGDGTHKEI--- 92

  Fly    94 EWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGS 157
            .|.::...:..|..||| ::.:|.|::|............|||::::|.|              :
  Rat    93 HWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNASHFYACGTHAFQPLC--------------A 143

  Fly   158 AGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR----ENLRTE 218
            |..|.|.....|.: |.:..|||.||...|....||.||:||..:|. ..|.|.|    .:||||
  Rat   144 AIDAEAFILPTSFE-EGKEKCPYDPARGFTGLIIDGGLYTATRYEFR-SIPDIRRSRHPHSLRTE 206

  Fly   219 QYDLKQLNQPDFV----------GAIERNGYVLFFFRELSMEVMNFGKAVYS----RVARVCKND 269
            :..:..||..:||          ..:..:..:.:||.|......:|.::..|    |||||||.|
  Rat   207 EAPMHWLNDAEFVFSVLVRESKTSVVGDDDKIYYFFMEREEGSSSFTQSRSSHRVARVARVCKGD 271

  Fly   270 RGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPI-VESGSKSLIYAVF--TTSVNAIPG 331
            .||.....|.|||||||||.|.:|     .::.::.:..: .::.|.:..||||  ||....:..
  Rat   272 LGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSLDADTSSHTHFYAVFTLTTQWKTLEA 331

  Fly   332 SAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVED---------SRTLTSIA 387
            ||:|.:::.:|.|.|.|.|...:|....|...| ..||:||||.|:.|         |:.|.|:.
  Rat   332 SAICRYDLAEIQAVFTGPFMEYQDGARRWGRYE-GGVPEPRPGSCITDSLRSRGYNSSQDLPSLV 395

  Fly   388 VNFIKNHPLMEEAVPAVHGRPLLTKVNLHH-RLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKF 451
            ::|:|.||||...|....|||||.|.|:.: .||  ..|..:.  :|..||:::.||.||.:.|.
  Rat   396 LDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHLT--GTHVSIP--AGPTYDLLFLGTADGWIHKA 456

  Fly   452 INILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVD 516
            : :|.:..:         :|.|:||......:..||||..::||.|.:...::..||..||....
  Rat   457 V-VLGSGMH---------IIEEIQVFRESQSVDNLVISPMQHSLYVGAASGVIQFPLSSCSRYRS 511

  Fly   517 CLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVS 581
            |..|:..:||.|.||..||.|....|..::                 ..|...|.|...|.|. |
  Rat   512 CYDCILARDPYCGWDSSTHACMVATTIANR-----------------TALIQDIERGNRGCEG-S 558

  Fly   582 FVTMAPPPTEEQKLLYSNVGSSQGNQPS-----------LEQQPTGGDDF--GLNKITLTSMDPD 633
            .....|||.:.:.:|..:......:|||           .:....|.|.:  |::.:.:|....:
  Rat   559 RDAGPPPPFKTRSVLRGDDVLLPCDQPSNLARALWLLNGSKSLSDGQDGYRVGVDGLLVTDTQLE 623

  Fly   634 -----DIMPNLNDPQKSTASVDEI----------KYASTPSFMLLTTI-VFFTFLVGGIAGICCV 682
                 ......|..:...||...|          :..:||...|...: :|:...:..:.|:|.:
  Rat   624 HSGNYGCYAEENGLRMLLASYSLIVRPATPAPAPQAPATPGAQLAHDMRLFYVVAIAILGGLCLI 688

  Fly   683 KAKSRLMEAQMDESHRNHFGKPMQFKHQNTGK 714
            .|.|.|..|.:....|   |:..::.....|:
  Rat   689 LASSLLYVACLRGGRR---GRRRKYSLGRAGR 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	148/493 (30%)
		PSI	510..>537	CDD:214655	11/26 (42%)
Sema4g	NP_001101996.1	Sema	47..504	CDD:472829	149/495 (30%)
		PSI	505..555	CDD:396154	16/66 (24%)
		Ig_Sema4B_like	565..648	CDD:409456	13/82 (16%)
		Ig strand A	565..571	CDD:409456	2/5 (40%)
		Ig strand B	575..583	CDD:409456	0/7 (0%)
		Ig strand C	589..595	CDD:409456	0/5 (0%)
		Ig strand C'	597..600	CDD:409456	0/2 (0%)
		Ig strand D	607..611	CDD:409456	0/3 (0%)
		Ig strand E	613..620	CDD:409456	1/6 (17%)
		Ig strand F	626..635	CDD:409456	0/8 (0%)