DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema6a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_003751830.1	Gene:	Sema6a / 361324	RGDID:	1305493	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	261/847 - (30%)
Similarity:	378/847 - (44%)	Gaps:	170/847 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PMILLITLSGLTIV-AGWMPDVKP-----DLQTKQDKV-LAHFIGNSTDYFKILDHN-----DEF 70
            |..||:.|:.|... ||:..|.:|     ...|||..| :.|..|.:|.....||..     :..
  Rat     3 PAALLLCLTLLRCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRT 67

  Fly    71 VLVGAKDVIYNVSL--NGLKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEV 130
            :.:.|:|.||.|.:  :..:||   .:|.|.|..||.:.|.:||||:.:|||:::|...:.:..:
  Rat    68 LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTL 132

  Fly   131 LLCGTNSYKPRCRHY---TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFAD 192
            .:||||::.|.||:|   |......|.:|.|                  .|||...|.:...|||
  Rat   133 FVCGTNAFNPSCRNYRVDTLETFGDEFSGMA------------------RCPYDAKHANIALFAD 179

  Fly   193 GHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVM 252
            |.||||||.||...|.:|||.     .|||.::|.|.|.:|.||.|::...|:.|||||:::|..
  Rat   180 GKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYN 244

  Fly   253 NFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKS 316
            ..||.|:.|||:|||||.||... ..|.|||||||||||||||:..|||:.:||::.::....:.
  Rat   245 TMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRD 309

  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVEDSR 381
            ::.|.|:|..|:||||||||:::.||...|.|.||.||...|.|.||..|:||||||| |...|.
  Rat   310 VVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPG-CCAGSS 373

  Fly   382 TLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY-- 435
            :|...|         :||||.||||:||||::..||...:..:.:|||.||    |.:.:|.|
  Rat   374 SLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIA----VDNTAGPYEN 434

  Fly   436 YDVIYSGTDDGKVTKFINIL--STHPNSTVDRLKTVVISEMQVLPLGTP------------IREL 486
            :.|::.|::.|.:.||:..:  |...|.      ::.:.||.|.   .|            |..:
  Rat   435 HTVVFLGSEKGIILKFLARIGSSGFLNG------SLFLEEMNVY---NPEKCSYDGVEDKRIMGM 490

  Fly   487 VISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTK 550
            .:..:..||.|.....::.|||..|.....| ..|::.:||.|.|..:|..|.:|:... :...:
  Rat   491 QLDKASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKETGSCAHLSPLS-RLAFE 554

  Fly   551 TYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTM----APPPTEEQKL---------LY-SNVG 601
            ..::..|:              |..|....|||.:    .|.|..|...         || |...
  Rat   555 QDIERGNT--------------DGLGDCHNSFVALNDISTPLPDYEMSFNTVYGRASSLYPSTTT 605

  Fly   602 SSQGNQPSLEQQPTGGDDFGLNKITLTSMDPDDIM--PNLNDPQKSTAS---------VDEIKYA 655
            |...::...|.|  ||           .:|.:|::  |...||..:.:|         :.|....
  Rat   606 SDSASRDGHESQ--GG-----------MLDWNDLLKAPGNTDPLGAVSSHNHQDKKGVIRESYLK 657

  Fly   656 STPSFM---LLTTIVFFTFLVG----GIAGIC-CVKAKSRLMEAQMDESHRNH------------ 700
            |....:   ||...|...|::|    ||...| |...:..:...|..|....|
  Rat   658 SNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKL 722

  Fly   701 ---FGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLE-KELPCKTST 761
               || ..|.|.......:..||.:....|...|..:.::.|:        .||: ..||...||
  Rat   723 SGLFG-DSQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQ--------HHLDLTALPTPEST 778

  Fly   762 LT 763
            .|
  Rat   779 PT 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	184/499 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/27 (30%)
Sema6a	XP_003751830.1	Sema_6A	48..513	CDD:200527	182/496 (37%)
Sema6a	XP_003751830.1	PSI	514..>544	CDD:396154	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.960