Protein Alignment Sema1b and Sema1a

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Alignment Length: 730
• Identity: 273/730 - (37%)
• Similarity: 382/730 - (52%)
• Gaps: 118/730 - (16%)

  Fly     1 MSSKSRPSSAAMLVNAI---------PMILLITLSGLTIVAGWMPDVKPDLQTK--QDKVLAHFI 54
            |..||..:.|.::.:.:         .:.||:|:..:...:.|..:::|.|..:  .:.|| .|:
  Fly    25 MHLKSATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVL-KFV 88

  Fly    55 GNST--DYFKILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHN 117
            ||.:  |:||::..:...:|:||::.::|:|::.|.|..||.|.|.:.|.::|.:|||.|..|.|
  Fly    89 GNESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQN 153

  Fly   118 YLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSP 182
            |:|:..:...|.:.:|||||::|.|..|    :.|:.          .|.:......|.:|||.|
  Fly   154 YIRIMVVPSPGRLFVCGTNSFRPMCNTY----IISDS----------NYTLEATKNGQAVCPYDP 204

  Fly   183 AHNSTYAFADGHLYSATVADFSGGDPLIYRENLRTEQYDLKQLNQPDFVGAIERNGYVLFFFREL 247
            .||||...||..|||.|||||||.||:||||.|:|||||...||.|:||.:..:..:|.|||||.
  Fly   205 RHNSTSVLADNELYSGTVADFSGSDPIIYREPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRET 269

  Fly   248 SMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVE- 311
            ::|.:|.|||:|||||||||.|:|||:.....||||||:|||||:||::||||:|||:.|.:||
  Fly   270 AVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG 334

  Fly   312 ---SGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRP 373
               |.|..|||.||.|..|:|||||||||.:.||...|:|:||.|....|:||||...:||.|||
  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399

  Fly   374 GQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDV 438
            |.|..|||.|....:||||.|.||:|.|||...:|:|.:.:..:|.|.|||..|:|:..|..|||
  Fly   400 GSCHNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDV 464

  Fly   439 IYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVI------------STS 491
            |:.|||.||:.|.:|..|.   .:.|::.:|||.|:.||....|||.|.|            |..
  Fly   465 IFVGTDHGKIIKSVNAESA---DSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYD 526

  Fly   492 KNSLVVVSDGSLVSVPLHHCSH--IVDCLGCLSLQDPICAWDLQTHECK---------------N 539
            ...|::|:|..:|::.||.|.:  |..|..|::||||.||||....:|:               |
  Fly   527 DGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQN 591

  Fly   540 LATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQ 604
            :||.||                 ||  ||....::..|                     |.|..:
  Fly   592 VATGQH-----------------AA--CPSGKINSKDA---------------------NAGEQK 616

  Fly   605 GNQPSLEQQPTGGDDFGLNKITLTSMDP---DDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTI 666
            |.:          :|..|......|.|.   |:|..|...||.| |.:...:|......|.:...
  Fly   617 GFR----------NDMDLLDSRRQSKDQEIIDNIDKNFEGPQIS-ADIINAQYTVETLVMAVLAG 670

  Fly   667 VFFTFLVGGIAGICC 681
            ..|:.|||...|..|
  Fly   671 SIFSLLVGFFTGYFC 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	215/473 (45%)
		PSI	510..>537	CDD:214655	12/28 (43%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	213/471 (45%)
		PSI	545..601	CDD:396154	20/74 (27%)