DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema3f

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_038937516.1	Gene:	Sema3f / 315996	RGDID:	1308514	Length:	802	Species:	Rattus norvegicus

Alignment Length:	690	Identity:	198/690 - (28%)
Similarity:	313/690 - (45%)	Gaps:	126/690 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSSAAMLVN-AIPMILLIT---LSGLTIVAGW-----------MPDVKPDLQTKQDKVLAHFIG- 55
            |.|.::|.. ..|..:|:|   |....:...|           .|.|:...:..:....|||..
  Rat     3 PQSWSLLPGPQAPPTMLVTGFILWASLLTGAWPAAPIQDQLPATPRVRLSFKELKATGTAHFFNF 67

  Fly    56 --NSTDY---FKILDHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EW 113
              |:|||   ||..||:..:  ||:||.:.::.|:.: :|...:.|.::....|.|.|.||. ..
  Rat    68 LLNTTDYRILFKDEDHDRMY--VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECILSGKDGNG 130

  Fly   114 DCHNYLRVYALRPNGEVLLCGTNSYKPRCRH-----------YTPVEV-----------SSEEAG 156
            :|.|::|:........:.:|||.:|.|.|.:           :|.::|           :.....
  Rat   131 ECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRSQAPPWTQMQVVRGRGSRATDGADRPTP 195

  Fly   157 SAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENL 215
            :|.....:.|.....:|: :|.|||.|..::..|..:..||:....||.|.|..|:|     ..:
  Rat   196 TAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAM 260

  Fly   216 RTEQYDLKQLNQPDFVGA------IERNGYVL-FFFRELSMEVMNFGKAVYSRVARVCKNDRGGP 273
            ||:||:.:.||.|.|:.|      .|||...| |||||.|.|... ..|||:|:.|:|.||.||.
  Rat   261 RTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGGH 324

  Fly   274 YSHGKSWTSFLKARLNCSVPGE--FPFYFDEIQAI---------SPIVESGSKSLIYAVFTTSVN 327
            ......|::||||||.||||||  ...:|||:|.:         :|:        ||||||:|.:
  Rat   325 CCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPV--------IYAVFTSSGS 381

  Fly   328 AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQC--------VEDSRTLT 384
            ...|||||.:::.||...|:|.|..::.....|:|.. .::|.||||.|        ::.::...
  Rat   382 VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTPSMKSTKDYP 445

  Fly   385 SIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVT 449
            ...:||::.||||.:||..:..|||:.:....:|||.:|| .||.:..|. |:|::.|||.|.|.
  Rat   446 DEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTVAV-DQVDAADGR-YEVLFLGTDRGTVQ 508

  Fly   450 KFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC-SH 513
            |.|.:    |... ..::.:::.|::|.....|::.:.||:.:..|.|.|...:..:.||.| ::
  Rat   509 KVIVL----PKDD-QEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAY 568

  Fly   514 IVDCLGCLSLQDPICAWDLQTHECKNLATSQHK------------------FGTKTYLQSLNSTK 560
            ...|..|...:||.||||.|.  |.....|..:                  |.:.....::.|.:
  Rat   569 GAACADCCLARDPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAIESVQ 631

  Fly   561 -----KAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL 595
                 .||.|.|.  || :|.| ||.::....|....:::
  Rat   632 YGVAGSAAFLECQ--PR-SPQA-TVKWLFQRDPSDRRREI 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	160/517 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)
Sema3f	XP_038937516.1	Sema_3F	65..565	CDD:200515	160/518 (31%)
		PSI	564..601	CDD:214655	12/38 (32%)
		Ig_Sema3	625..714	CDD:409455	12/47 (26%)
		Ig strand B	639..643	CDD:409455	2/3 (67%)
		Ig strand C	651..655	CDD:409455	2/3 (67%)
		Ig strand E	678..682	CDD:409455
		Ig strand F	692..697	CDD:409455
		Ig strand G	709..712	CDD:409455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910