DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema6d

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_038960912.1	Gene:	Sema6d / 311384	RGDID:	1310910	Length:	1086	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	249/761 - (32%)
Similarity:	365/761 - (47%)	Gaps:	124/761 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GNST----DYFKILDHNDEFVLVGAKDVIYNVSLNGLKEI-----ARLEWHSTDADRELCALKGK 110
            ||.:    |:..:|...|...:.| :|.:|.|:||.:.:.     .:|.|.|...|||.||:|||
  Rat    50 GNESQHRLDFQLMLKIRDTLYIAG-RDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGK 113

  Fly   111 HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVE 173
            |:.:|||:::|:..|.:..|.:||||::.|.||:|  :.:|...||                 :.
  Rat   114 HKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEE-----------------IS 161

  Fly   174 AQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGA 233
            ....||:.....:...||||.|||||||||...|.:|||     ..|||.:||.|.:.:|.|:.|
  Rat   162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226

  Fly   234 IERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFP 297
            ||...||.|||||:::|..|.||||||||||:||||.||... ..|.|||||||||||||||:..
  Rat   227 IEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291

  Fly   298 FYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLP 362
            ||||.:|:|:.|::......:..||||.:|:|||||||||::|||...|.|.||.||...|.|..
  Rat   292 FYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTA 356

  Fly   363 VEREQVPKPRPGQCVEDSRT---LTSI-----AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRL 419
            |..::|||||||.|.:....   .|||     .::|||:||||:.|||.:...|..||..:.:||
  Rat   357 VPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRL 421

  Fly   420 TAIAVHPQVKSLSGAY--YDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTP 482
            |||    :|...:|.|  |.||:.|::.|.|.|.  :..|.|.|..|   :|::.|::..   .|
  Rat   422 TAI----EVDRSAGPYQNYTVIFVGSEAGVVLKV--LAKTSPFSLND---SVLLEEIEAY---NP 474

  Fly   483 IR------------ELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQT 534
            .:            .|.:....::|.|.....:|.:||..|.....| ..|::.:||.|.| |..
  Rat   475 AKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGW-LSQ 538

  Fly   535 HECKNLATSQ----------HKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPP 589
            ..|:.:....          |......|.|.......|....| |  ...|.:.|..:.... .|
  Rat   539 GVCERVTLGMLLLTEDFFAFHNHSAGGYEQDTEYGNTAHLGDC-H--ESLPTSTTPDYKIFG-GP 599

  Fly   590 TEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNKITLTS--MDPDDIMPNLNDPQKSTASVD-- 650
            |.:.::..|:| ::..:.|.:..:..   |....|:|.:.  :..||  ||.:|...:.:.:.
  Rat   600 TSDMEVPSSSV-TTVASSPEITSKVI---DTWRPKLTSSRKFVVQDD--PNTSDFTDTISGIPKG 658

  Fly   651 ---EIKYASTPSFM---LLTTIVFFTFLVGG-IAGIC--CVK----AKSRLMEAQMDESH----- 697
               |::...:...:   :|.|.||..|::|. |||:.  |.:    .|:|.:....:.:.
  Rat   659 VRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDS 723

  Fly   698 -------RNHFGKPMQFKHQNTGKDINLLMGSNAYTTTQK-TPNLD 735
                   ...|..|::...||....   .:.||..|:.:: .||.|
  Rat   724 SGSFAKLNGLFDSPVKEYQQNIDSP---KLYSNLLTSRKELPPNTD 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	196/494 (40%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/27 (30%)
Sema6d	XP_038960912.1	Sema	49..513	CDD:417757	195/492 (40%)
Sema6d	XP_038960912.1	PSI	514..>543	CDD:396154	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860