DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema5a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001101129.1	Gene:	Sema5a / 310207	RGDID:	1308650	Length:	1074	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	183/504 - (36%)
Similarity:	259/504 - (51%)	Gaps:	54/504 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NSTDYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYL 119
            |:.|:.:: .|...:.::|||::.::.:.|..|..|..::|...:|.::.|..|||.:.:|.||:
  Rat    54 NAVDFSRLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKKACYSKGKSKEECQNYI 118

  Fly   120 RVYALRPNGEVLL-CGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPA 183
            ||  |...|:.|. ||||::.|.|...:...::               |:...:.....|||||.
  Rat   119 RV--LLVGGDRLFTCGTNAFTPVCTIRSLSNLT---------------EIHDQISGMARCPYSPQ 166

  Fly   184 HNSTYAF-ADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLF 242
            ||||... |.|.||:||..||.|.||.|||.     .|||.||:.|.||:|:||.:.:...:..|
  Rat   167 HNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYF 231

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAIS 307
            ||||.::| .:.||.|:||.|||||||.||.:....:||:|:|||||||.|||.|||::|:|:..
  Rat   232 FFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTF 295

  Fly   308 PIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPR 372
            .:.|   ..|||.:|||:||:|..||||.||:..|..||:|.||.|::|:|.|||     .|.|.
  Rat   296 FLPE---LDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP-----YPNPN 352

  Fly   373 PG-QCVEDSR----TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLS 432
            |. ||....:    .||...:...:...||.|.|..|...|...:.|  .|.:.:||  .|....
  Rat   353 PNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDN--SRFSHVAV--DVVQGR 413

  Fly   433 GAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLP--LGTPIRELVISTSKNSL 495
            .....:||..||.|.:.|....||....|       .::.|:::.|  ...|||.|.|..|::.|
  Rat   414 DTLVHIIYLATDYGTIKKVRAPLSQSSGS-------CLLEEIELFPERKSEPIRSLKILHSQSVL 471

  Fly   496 VVVSDGSLVSVPLHHCSHIVDCLG-CLSLQDPICAWDLQTHECKNLATS 543
            .|.....:|.:||..| |.....| |:..|||.|.||....:|.:|..|
  Rat   472 FVGLQEHVVKIPLKRC-HFHQTRGACIGAQDPYCGWDAVMKKCTSLEES 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	170/469 (36%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)
Sema5a	NP_001101129.1	Sema_5A	50..485	CDD:200524	169/467 (36%)
		PSI	486..533	CDD:279745	13/35 (37%)
		TSP1	544..595	CDD:214559
		TSP1	598..651	CDD:214559
		TSP1	656..702	CDD:214559
		TSP1	787..839	CDD:214559
		TSP1	853..896	CDD:214559
		TSP1	899..940	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810