DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema5b

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_038944267.1	Gene:	Sema5b / 303901	RGDID:	1308914	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	206/591 - (34%)
Similarity:	304/591 - (51%)	Gaps:	80/591 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PMILLITLSGLTIVAGWM---------PDVKPDLQTKQDKVLAHF------IGNST-----DYFK 62
            |:.|.:.|...|::...:         |..:..|.|:::..:..|      :.|.|     |:.:
  Rat     6 PLALSLLLPSFTLLLSHLSTSQDITSEPSSEQQLCTRREHPIVAFEDLKPWVSNFTYPGVRDFSQ 70

  Fly    63 I-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
            : ||.:...::|||::.::.:||..:..:...||.|::..|..|..|||.|.:|.||:||..: .
  Rat    71 LALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIV-S 134

  Fly   127 NGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAF- 190
            ..:|.:||||::.|.|        ||.:.|:...|......|:|       |||.|.||||...
  Rat   135 GRKVFMCGTNAFSPVC--------SSRQVGNLSRAIEKINGVAR-------CPYDPRHNSTAVIS 184

  Fly   191 ADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSME 250
            :.|.||:|||.||||.||.|||.     .|||.||:.|.||:|:||.|.:...:..||.||.::|
  Rat   185 SQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAFDIGLFAYFFLRENAVE 249

  Fly   251 VMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSK 315
             .:.|:.||||||||||||.||.:....:||:|:|||||||.|||.|||::|:|:...:.|   :
  Rat   250 -HDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPE---Q 310

  Fly   316 SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVE-- 378
            .|||.||||:||:|..|||||||:..|..||:|.|:.|::.::.|||: ...:|..:.|...|
  Rat   311 DLIYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTLPETG 374

  Fly   379 DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTK--VNLHHRLTAIAVHPQVKSLSGAYYDVIYS 441
            .:..||..::...:...||.|||..|...|.:|:  |...|.:..:.   |.|.   ..|.|:|.
  Rat   375 PNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLV---QAKD---TLYHVLYI 433

  Fly   442 GTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLG--TPIRELVISTSKNSLVVVSDGSLV 504
            ||:.|.:.|   .|||...|    |:...:.|:.|||.|  .|:|.|.|..|..:|.|.....::
  Rat   434 GTESGTILK---ALSTASRS----LRGCYLEELHVLPPGRLEPLRSLRILHSARALYVGLSDRVL 491

  Fly   505 SVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAALLCP- 568
            .|||..||..:....||..:||.|.||.:...|..|..|.:   ...::|::.:        ||
  Rat   492 RVPLERCSAYLSQGACLGARDPYCGWDGKRQLCSTLEDSSN---MSLWIQNITA--------CPV 545

  Fly   569 -HIPRD 573
             ::.||
  Rat   546 RNVTRD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	181/473 (38%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
Sema5b	XP_038944267.1	Sema	60..496	CDD:417757	179/469 (38%)
		PSI	497..544	CDD:396154	13/57 (23%)
		TSP1	609..662	CDD:214559
		TSP1	667..713	CDD:214559
		TSP1	798..850	CDD:214559
		TSP1	855..907	CDD:214559
		TSP_1	911..952	CDD:417691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810