DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema3h

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001315307.1	Gene:	sema3h / 30252	ZFINID:	ZDB-GENE-990715-8	Length:	749	Species:	Danio rerio

Alignment Length:	523	Identity:	164/523 - (31%)
Similarity:	253/523 - (48%)	Gaps:	56/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADR-ELCALKGKH-EWDCHNYLRVYALRPN 127
            |.:...:.:|.||.:.:.||:.:.:..|..:...:.|| :.|.:.||. |.||.|:|||......
Zfish    54 DEDGRRLYIGMKDHLLSTSLDDITQNPRKIYWPANPDRIQDCTMAGKTLEMDCANFLRVLERYNQ 118

  Fly   128 GEVLLCGTNSYKPRCRHY-TPVEVSSEEAGSAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYAF 190
            ..:..|||.::.|||... |.:.:.:||       ..::.|   |.|: :|.||:.|...:..|.
Zfish   119 THLYACGTGAFNPRCAFIPTNLFLRAEE-------QTLQDE---DTESGRGKCPFDPHQRTATAI 173

  Fly   191 ADGHLYSATVADFSGGD-----PLIYRENLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFF 243
            .||.||:...:||...|     .|..|..:||||||...|...:||...       |.:..|..|
Zfish   174 IDGELYAGISSDFLSHDTAFIRSLGERHVIRTEQYDSTWLQGAEFVHVTAMSESDNEEDDKVYVF 238

  Fly   244 FRELSMEVMN-FGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FPFYFDEIQA 305
            |.|.:.|... .||.:|||||||||||.||..|....|::|.|||:.|||||.  ...:||::|.
Zfish   239 FTERAQEAEGAAGKVLYSRVARVCKNDIGGQRSLVNKWSTFQKARIVCSVPGPDGIQTHFDKLQD 303

  Fly   306 ISPIVESG---SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQ 367
            |  .::.|   ...|:|.:|||:.|.:.|||||.:.:.||:.||.|.| ..::...:.|.....:
Zfish   304 I--FIQHGRDKKNPLVYGLFTTTSNVLNGSAVCVYRMQDIIRAFKGNF-LHREGHQYKLTEYTGR 365

  Fly   368 VPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVH 425
            ||.||||.|       ...:|......:.|.:.||||:|.|..:.|:|||.:|.:.::||.:.|
Zfish   366 VPYPRPGTCPSSTYGGFRSTREYPDDVIFFSRTHPLMQEVVRPLGGQPLLIRVGVPYKLTRLLV- 429

  Fly   426 PQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIST 490
            .:|:::.| .:||::.|||.|.|.|.::....:..:     :.|.:.::||....:.|..:.:|.
Zfish   430 DRVEAVDG-QHDVMFIGTDSGLVLKVLHFPKANRQN-----QEVTLEQLQVFKHKSAITAMTLSK 488

  Fly   491 SKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQ 554
            .|..|...|...:|.:.|..|. :...|..|...:||.|.||  .|.|.....:    |.:..::
Zfish   489 KKQWLFAGSAEGVVQLGLFQCDLYGQACAECCLARDPYCTWD--GHSCSQFMPT----GRRRNIR 547

  Fly   555 SLN 557
            .:|
Zfish   548 QVN 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	152/474 (32%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/27 (33%)
sema3h	NP_001315307.1	Sema_3	39..509	CDD:200500	152/474 (32%)
		PSI	508..>544	CDD:214655	11/41 (27%)
		Ig_Semaphorin_C	570..661	CDD:143180
		IG_like	573..658	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910