Protein Alignment Sema1b and Sema4f

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_062145.1
• Gene: Sema4f / 29745
• RGDID: 3658
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 802
• Identity: 215/802 - (26%)
• Similarity: 343/802 - (42%)
• Gaps: 174/802 - (21%)

  Fly    18 PMILLITLSGLTI-VAGWMPDVKPDLQ---TKQDKVLAHFIGNST-DYFKIL-DHNDEFVLVGAK 76
            |:.||:.|:.|:. |.|.:|...|...   ::.|..|..|..:.| :|..:| |.....:.|||:
  Rat    23 PLSLLLLLAILSAPVCGRVPRSVPRTSLPISEADSYLTRFAASHTYNYSALLVDPASHTLYVGAR 87

  Fly    77 DVIYNVSL--NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYK 139
            |.|:.::|  :| :...|::|...:..|:.|..|||.|.:|||::::.|:.....:|.|||.::.
  Rat    88 DSIFALTLPFSG-ERPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIVNASHLLTCGTFAFD 151

  Fly   140 PRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFS 204
            |:|   ..::|||.:            :|.|....:|.||:.||..|....|.|.||:|||.:|.
  Rat   152 PKC---GVIDVSSFQ------------QVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFL 201

  Fly   205 GGDPLIYR------ENLRTEQYDLKQLNQPDFVGAI----------ERNGYVLFFFRELSMEVMN 253
            |.:|:|.|      :.:|||... ..||.|.||.|:          :.:..:.|||.|.|..:.:
  Rat   202 GTEPIISRAVGRAEDWIRTETLS-SWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDS 265

  Fly   254 FGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVP--GEFPFYFDEIQAISPIVESGSKS 316
            :.:....||||||..|.||..:..:.||:||||.|.|..|  |........:..:.|...:|: .
  Rat   266 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQAMAELRPQPGAGT-P 329

  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVED-- 379
            :.|.:|::.......||||||...||.|..:|.|:..|...:..|||...:||:||||:|:.:
  Rat   330 IFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIANNM 394

  Fly   380 -------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYD 437
                   |.:|....:.||::||||:..|....|||||...:..:  ..:..| :|.||||..||
  Rat   395 KLQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAY--LRVVAH-RVTSLSGKEYD 456

  Fly   438 VIYSGTDDGKVTKFINI---LSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVS 499
            |:|.||:||.:.:.:.|   ||             |:.::.:.|...|:..:.:  ..:.|:|.|
  Rat   457 VLYLGTEDGHLHRAVRIGAQLS-------------VLEDLALFPEPQPVESMKL--YHDWLLVGS 506

  Fly   500 DGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAA 564
            ...:..|...:|..:..|..|:..|||:|||..:...|...| .:|    :..:|.:.|...::
  Rat   507 HTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHA-GEH----RGMVQDIESADVSS- 565

  Fly   565 LLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNK 624
             |||..|.:.|     ...||..|.:...|:       |...|...:|||           |:..
  Rat   566 -LCPKEPGEHPVVFEVPVATVGHVVLPCSPS-------SAWASCVWHQPS-----------GVTA 611

  Fly   625 ITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAGIC-------CV 682
            :|               |::     |.::...||..|            |..|..|       .|
  Rat   612 LT---------------PRR-----DGLEVVVTPGAM------------GAYACECQEGGAARVV 644

  Fly   683 KAKSRLMEAQMDESHRNH-----------------------FGKPMQFKHQ-------NTGKDIN 717
            .|.|.:..:|...|:|.|                       .|:..|.:.|       ..|.|:.
  Rat   645 AAYSLVWGSQRGPSNRAHTVVGAGLVGFLLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLG 709

  Fly   718 L-LMGSNAYTTTQKTPNLDLEK 738
            . ..|:.:|:....:|:.:.|:
  Rat   710 APPSGTTSYSQDPPSPSPEDER 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	149/489 (30%)
		PSI	510..>537	CDD:214655	9/26 (35%)
Sema4f	NP_062145.1	Sema_4F	57..516	CDD:200522	151/494 (31%)
		PSI	517..568	CDD:396154	15/57 (26%)
		Sema4F_C	581..776	CDD:437260	35/201 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	702..741		6/30 (20%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9Z123	774..776