DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema3c

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_008760867.1	Gene:	Sema3c / 296787	RGDID:	1309343	Length:	760	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	166/568 - (29%)
Similarity:	282/568 - (49%)	Gaps:	65/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDL------QTKQDKV--LAHFIGNSTDY-FKIL 64
            |..|.:..|.:::.:.:..:.:.....|..:..|      :||..:.  |:|   ...|| ..::
  Rat     4 SEEMALREICVLVGVFICSICVQGSSQPQARVYLTFDELRETKTSEYFSLSH---QQLDYRILLM 65

  Fly    65 DHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGK---HEWDCHNYLRVYALR 125
            |.:.:.:.||:||.|.::::|.: :|...:.|.::....|.|.:.||   |  .|.|::||....
  Rat    66 DEDQDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECKMAGKDPTH--GCGNFVRVIQTF 128

  Fly   126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYA 189
            ....:.:||:.::.|.|.:......|.::.          :.:....|: :|.|.::|..|:...
  Rat   129 NRTHLYVCGSGAFSPVCTYLNRGRRSEDQV----------FMIDSKCESGKGRCSFNPNVNTVSV 183

  Fly   190 FADGHLYSATVADFSGGDPLIY-----RENLRTEQYDLKQLNQPDFV-------GAIERNGYVLF 242
            ..:..|:|....||.|.|..|:     |..:||:|::.|.|::|.||       |....:..|.|
  Rat   184 MINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYF 248

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF--PFYFDEIQA 305
            ||:|...:.....|.::|.|||:|.||.||..|....||:||||||.|||..|.  ..:|||::.
  Rat   249 FFKERLTDNNRSTKQIHSMVARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELED 313

  Fly   306 ISPI-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVP 369
            :..: .::...:|:|.:||||.:...|||||.:::.||...|:|.| :.|:..:|.|...:.::|
  Rat   314 VFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPF-AHKEGPNHQLISYQGRIP 377

  Fly   370 KPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHP 426
            .||||.|        :..::......|.||:|||||..::..:|.|||:.::...::.|.||| .
  Rat   378 YPRPGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAV-D 441

  Fly   427 QVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTS 491
            :|.:..|.|: |::.|||.|.|.|.: :|.|:.:::.:    :::.|::|.....||..:.||:.
  Rat   442 RVNAADGRYH-VLFLGTDRGTVQKVV-VLPTNSSASGE----LILEELEVFKNHVPITTMKISSK 500

  Fly   492 KNSLVVVSDGSLVSVPLHHCSHI--VDCLGCLSLQDPICAWDLQTHEC 537
            |..|.|.|:..:..|.||.| ||  ..|..|...:||.||||  .|.|
  Rat   501 KQQLYVSSNEGVSQVSLHRC-HIYGTACADCCLARDPYCAWD--GHSC 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	144/484 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	12/28 (43%)
Sema3c	XP_008760867.1	Sema_3C	51..520	CDD:200512	146/491 (30%)
		PSI	519..556	CDD:214655	13/30 (43%)
		Ig_Semaphorin_classIII	584..673	CDD:143279
		IG_like	588..662	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910