DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4b

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001163933.1	Gene:	Sema4b / 293042	RGDID:	1307872	Length:	821	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	231/837 - (27%)
Similarity:	358/837 - (42%)	Gaps:	158/837 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHFIGNSTDYFKILDHND-E 69
            |.|.:|.|::|:.::||:..:......|  |.:...|.:::..:......|.::|..:|...| :
  Rat     3 RASRSADLLSALQLLLLLLRTTTARALG--PRISVPLDSEERLIRKFEAENISNYTALLLSQDGK 65

  Fly    70 FVLVGAKDVIY--NVSLNGLK--EIARLEWHSTDADR-ELCALKGKH-EWDCHNYLRVYALRPNG 128
            .:.|||::.::  |.:|:.|.  |...|.| |.|.|| :.|:.|||. :.||.||:::.....:.
  Rat    66 TLYVGAREALFALNSNLSFLPGGEYQELLW-SADPDRKQQCSFKGKDPKRDCQNYIKILLPLNSS 129

  Fly   129 EVLLCGTNSYKPRCRHYTPVE--VSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            .:|.|||.::.|.|.:.....  ::.:||||      :..|     :.:|.||:.|...||....
  Rat   130 HLLTCGTAAFSPLCAYINTASFTLARDEAGS------VLLE-----DGKGRCPFDPNFKSTALVV 183

  Fly   192 DGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFVGA----------IERNGYVLF 242
            ||.||:.||:.|.|.||.|.|..    .:||. .|..|..|.||.:          |..:..:.|
  Rat   184 DGELYTGTVSSFQGNDPAISRSQSPRPTKTES-SLNWLQDPAFVASAYVPESLGSPIGDDDKIYF 247

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE-FPF-YFDEIQA 305
            ||.|...|...|...:.||||||||.|.||.....:.|||||||:|.||.|.: ||| ...::..
  Rat   248 FFSETGQEFEFFENTIVSRVARVCKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFT 312

  Fly   306 ISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQV 368
            ::|..:...|:|.|.|||:..:  ...|||:|.|.::|:..||||.:|........|. .|...|
  Rat   313 LNPNPQDWRKTLFYGVFTSQWHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWY-TETHPV 376

  Fly   369 PKPRPGQCVEDS---RTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAV 424
            |.||||.|:.:|   |.:.|.      .:||:|:|.||:..|     |..|..:....|...:||
  Rat   377 PTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV-----RSRLLLLQPQARYQRVAV 436

  Fly   425 HPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIS 489
            | :|..|... |||::.||.||::.|.:.:.|          :..:|.|:||.|.|.|::.|::.
  Rat   437 H-RVPGLHST-YDVLFLGTGDGRLHKAVTLDS----------RVHIIEELQVFPQGQPVQNLLLD 489

  Fly   490 TSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQ 554
            :....|...|...:|.||:.:||....|..||..:||.|||:..|  ||.|:..|....::.::|
  Rat   490 SHGGLLYASSHSGVVQVPVANCSLYPTCGDCLLARDPYCAWNGST--CKLLSLYQPDLASRPWIQ 552

  Fly   555 SLN--STKKAAALLCPHIPRDAPG---------AETVSFVTMAPPPTEEQKLLYSNV-------- 600
            .:.  :||:...:.........||         |.||:  |:|.|       |.||:
  Rat   553 DIEGANTKELCNISSAKARSFKPGKPCKQVQIQANTVN--TLACP-------LLSNLATRLWLHN 608

  Fly   601 GSSQGNQPSLEQQPTG-----GDDFGLNKITLTSMD--------------PDDIMPNLNDPQKST 646
            |:......|....|:|     |...||......|::              .:|.:.:.||....|
  Rat   609 GAPVNASASCRVLPSGDLLLVGSQQGLGVFQCWSIEEGFRQLVASYCPEVKEDGVMDQNDQSDGT 673

  Fly   647 ASVDEIKYASTPS---------------FMLLTT---------IVFF---------TFLVGGIAG 678
            ..:......|.|:               |:::.|         ::||         .||..|.
  Rat   674 PVIINTSRVSAPAGGRASWGADKSYWNEFLVMCTLFGLAVVLLVLFFLYRNRDGMKLFLKQGE-- 736

  Fly   679 ICCVKAKSRLMEAQMDESHR--NHFGKP-MQFKHQNTGKDINLLMGSNAYTTTQKTP 732
              |.....:...|.:....|  |..|.| ....|:......:...|...:|.::|.|
  Rat   737 --CASVHPKTRPAVLPPETRPLNGVGPPSTPLDHRGYQALSDSSPGPRVFTESEKRP 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	160/491 (33%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/26 (42%)
Sema4b	NP_001163933.1	Sema	46..509	CDD:417757	160/493 (32%)
		PSI	510..556	CDD:396154	16/47 (34%)
		Ig_Sema4B_like	577..661	CDD:409456	17/92 (18%)
		Ig strand B	590..594	CDD:409456	1/5 (20%)
		Ig strand C	602..606	CDD:409456	0/3 (0%)
		Ig strand E	624..627	CDD:409456	1/2 (50%)
		Ig strand F	637..642	CDD:409456	0/4 (0%)
		Ig strand G	654..657	CDD:409456	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010