DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4g

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_036106.1	Gene:	Sema4g / 26456	MGIID:	1347047	Length:	837	Species:	Mus musculus

Alignment Length:	798	Identity:	212/798 - (26%)
Similarity:	343/798 - (42%)	Gaps:	144/798 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLITLSGLTIVAGWMP---------DVKPDLQTKQDKV--LAHFIGNSTDYFK-ILDHNDEFVLV 73
            ||.:...:|.|.|  |         |..|.|....:::  :.||.|.:.:|.. :|:...|.:||
Mouse     8 LLFSFLTVTAVPG--PSLRRPSRELDATPRLTISYEELSQIRHFKGQTQNYSTLLLEEASERLLV 70

  Fly    74 GAKDVIYNVSLNGLKEIARLE--WHSTDADRELCALKGK-HEWDCHNYLRVYALRPNG-EVLLCG 134
            ||:..::::|...:::....|  |.::...:..|..||| ::.:|.|::| :..|.|. ....||
Mouse    71 GARGALFSLSARDIRDRTHKEIHWEASPEMQSKCHQKGKNNQTECFNHVR-FLQRLNATHFYACG 134

  Fly   135 TNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSAT 199
            |::::|.|              :|..|.......|.: |.:..|||.||...|....||.||:||
Mouse   135 THAFQPLC--------------AAIDAETFILPTSFE-EGKEKCPYDPARGFTGLIIDGGLYTAT 184

  Fly   200 VADFSGGDPLIYR----ENLRTEQYDLKQLNQPDFV----------GAIERNGYVLFFFRELSME 250
            ..:|. ..|.|.|    .:||||:..:..||..:||          .|:..:..:.|||.|....
Mouse   185 RYEFR-SIPDIRRSRHPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEG 248

  Fly   251 VMNFGKAVYS----RVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPI-V 310
            ..:|.::..|    |||||||.|.||.....|.|||||||||.|.:|     .::.::.:..: .
Mouse   249 SSSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSLNA 308

  Fly   311 ESGSKSLIYAVF--TTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRP 373
            ::.|.:..||||  ||....:..||:|.:::.:|.|.|.|.|...:|....|...| ..||:|||
Mouse   309 DTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRWGRYE-GGVPEPRP 372

  Fly   374 GQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHH-RLTAIAVHPQV 428
            |.|:.|         |:.|.|:.::|:|.||||...|....|||||.|.|:.: .||.    ..|
Mouse   373 GSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHLTG----THV 433

  Fly   429 KSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKN 493
            .:.:|..||:::.||.||.:.|.: :|.:..:         :|.|:||......:..||||..::
Mouse   434 STPAGPTYDLLFLGTADGWIHKAV-VLGSGMH---------IIEEIQVFREPQSVDNLVISPMQH 488

  Fly   494 SLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNS 558
            ||.|.:...::..||..||....|..|:..:||.|.||...|.|. :||:           ..|.
Mouse   489 SLYVGAASGVLQFPLSSCSRYQSCYDCILARDPYCGWDSSIHACM-VATT-----------VANR 541

  Fly   559 TKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPS-----------LEQ 612
            |:     |...|.|...|.|. |.....|||.:.:.:|..:......:|||           .:.
Mouse   542 TE-----LIQDIERGNRGCEG-SRDAGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSKS 600

  Fly   613 QPTGGDDF--GLNKITLTSMDPDD---------------IMPNLNDPQKSTASVDEIKYASTPSF 660
            ...|.|.:  |::.:.:|....:.               ::.:.:...:........:..:||..
Mouse   601 LSDGQDGYRVGVDGLLVTDTQLEHSGNYGCYAEENGLRMLLASYSLTVRPATPAPAPQAPATPGA 665

  Fly   661 MLLTTI-VFFTFLVGGIAGICCVKAKSRLMEAQMDESHRNHFGKPMQFKHQNTGKDINLLMGSNA 724
            .|...: :|:...:..:.|:|.:.|.|.|..|.:....|   |:..::.....|:     .|.:|
Mouse   666 QLAHDMRMFYVVAIAILGGLCLILASSLLYVACLKGGRR---GRRRKYSLGRAGR-----AGGSA 722

  Fly   725 ---YTTTQKTPNLDLEKD 739
               .|.:.:.|..:.|.|
Mouse   723 VQLQTVSGQCPGEEDEGD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/491 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/26 (38%)
Sema4g	NP_036106.1	Sema	47..504	CDD:417757	151/493 (31%)
		PSI	505..555	CDD:396154	18/66 (27%)
		Ig_Sema4B_like	565..648	CDD:409456	10/82 (12%)
		Ig strand B	578..582	CDD:409456	0/3 (0%)
		Ig strand C	590..594	CDD:409456	0/3 (0%)
		Ig strand E	613..617	CDD:409456	0/3 (0%)
		Ig strand F	627..632	CDD:409456	0/4 (0%)
		Ig strand G	644..647	CDD:409456	0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..776		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910