Protein Alignment Sema1b and SEMA3D

DIOPT Version :9

• Sequence 1: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_001371829.1
• Gene: SEMA3D / 223117
• HGNCID: 10726
• Length: 777
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 180/571 - (31%)
• Similarity: 285/571 - (49%)
• Gaps: 63/571 - (11%)

  Fly    18 PMILLITLSGLTI-VAGWMPDVKPDLQ-TKQDKVLAH----FIGNS--TDY-FKILDHNDEFVLV 73
            |.:::::::.|.: |.|.:....|.|: |.:|.:|::    |:|:|  .|: ..:||.....:|:
Human    20 PALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLL 84

  Fly    74 GAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGE--VLLCG 134
            ||||.|:.:||..| |...::.|.:.....|||.|.||. ..:|.|::||  |:|..:  :.:||
Human    85 GAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRV--LQPYNKTHIYVCG 147

  Fly   135 TNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGL-CPYSPAHNSTYAFADGHLYSA 198
            |.::.|.| .|..:.|..|:.......|        ::|:..| ||:.|.........|.:|||.
Human   148 TGAFHPIC-GYIDLGVYKEDIIFKLDTH--------NLESGRLKCPFDPQQPFASVMTDEYLYSG 203

  Fly   199 TVADFSGGDPLIYR--------ENLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELS 248
            |.:||.|.|....|        ..:||:..:...||...|:|..       ..:..:.|||||.|
Human   204 TASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESS 268

  Fly   249 MEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FPFYFDEIQAISPIVE 311
            .|.....|.:.|||.||||||.||..|....||:||||||.||:||.  ...||||:|.|..:..
Human   269 QEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPT 333

  Fly   312 SGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQ 375
            ...:: ::|.||||:.:...|||||.:::.||.|.|:|.:..::.:...|:..: .::|.||||.
Human   334 RDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYD-GRIPYPRPGT 397

  Fly   376 C--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLS 432
            |        ::.:|......::|||.|.:|.::|..|.|.|...::|:.:|||.|.|...:  ..
Human   398 CPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVI--AE 460

  Fly   433 GAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVV 497
            ...|||::.|||.|.|.|.::|.....|     ::.||:.|:|:....:.|..:.:|..:..|.:
Human   461 DGQYDVMFLGTDIGTVLKVVSISKEKWN-----MEEVVLEELQIFKHSSIILNMELSLKQQQLYI 520

  Fly   498 VSDGSLVSVPLHHC-SHIVDCLGCLSLQDPICAWDLQTHECKNLA-TSQHK 546
            .|...||.:.||.| ::...|..|...:||.||||  .:.|...| ||:.:
Human   521 GSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWD--GNACSRYAPTSKRR 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	157/489 (32%)
		PSI	510..>537	CDD:214655	9/27 (33%)
SEMA3D	NP_001371829.1	Sema_3D	61..534	CDD:200513	158/491 (32%)
		PSI	533..570	CDD:214655	13/39 (33%)
		Ig_Sema3	595..686	CDD:409455
		Ig strand B	609..613	CDD:409455
		Ig strand C	621..625	CDD:409455
		Ig strand E	648..652	CDD:409455
		Ig strand F	662..667	CDD:409455
		Ig strand G	679..682	CDD:409455
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910