DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema6d

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_006499174.1	Gene:	Sema6d / 214968	MGIID:	2387661	Length:	1086	Species:	Mus musculus

Alignment Length:	777	Identity:	255/777 - (32%)
Similarity:	367/777 - (47%)	Gaps:	129/777 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GNST----DYFKILDHNDEFVLVGAKDVIYNVSLNGLKEI-----ARLEWHSTDADRELCALKGK 110
            ||.:    |:..:|...|...:.| :|.:|.|:||.:.:.     .:|.|.|...|||.||:|||
Mouse    50 GNESQHRLDFQLMLKIRDTLYIAG-RDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKGK 113

  Fly   111 HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQ 175
            |:.:|||:::|:..|.:..|.:||||::.|.||:|              ....:.|: ..::...
Mouse   114 HKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYY--------------RLRTLEYD-GEEISGL 163

  Fly   176 GLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAIE 235
            ..||:.....:...||||.|||||||||...|.:|||     ..|||.:||.|.:.:|.|:.|||
Mouse   164 ARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIE 228

  Fly   236 RNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFY 299
            ...||.|||||:::|..|.||||||||||:||||.||... ..|.|||||||||||||||:..||
Mouse   229 YGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

  Fly   300 FDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVE 364
            ||.:|:|:.|::......:..||||.:|:|||||||||::|||...|.|.||.||...|.|..|.
Mouse   294 FDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVP 358

  Fly   365 REQVPKPRPGQCVEDSRT---LTSI-----AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTA 421
            .::|||||||.|.:....   .|||     .:.|||:||||:.|||.:...|..||..:.:||||
Mouse   359 EDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTA 423

  Fly   422 IAVHPQVKSLSGAY--YDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIR 484
            |    :|...:|.|  |.||:.|::.|.|.|.  :..|.|.|..|   :|::.|::..   .|.:
Mouse   424 I----EVDRSAGPYQNYTVIFVGSEAGVVLKV--LAKTSPFSLND---SVLLEEIEAY---NPAK 476

  Fly   485 ------------ELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHE 536
                        .|.:....::|.|.....:|.:||..|.....| ..|::.:||.|.| |....
Mouse   477 CSAESEEDRKVVSLQLDKDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGW-LSQGV 540

  Fly   537 CKNLATSQ----------HKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTE 591
            |:.:....          |......|.|.......|....| |  ...|.:.|..:.... .||.
Mouse   541 CERVTLGMLLLTEDFFAFHNHSPGGYEQDTEYGNTAHLGDC-H--ESLPPSTTPDYKIFG-GPTS 601

  Fly   592 EQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNKITLTS--MDPDDIMPNLNDPQKSTASVD---- 650
            :.::..|:| ::..:.|.:..:..   |....|:|.:.  :..||  ||.:|...:.:.:.
Mouse   602 DMEVSSSSV-TTVASSPEITSKVI---DTWRPKLTSSRKFVVQDD--PNTSDFTDTISGIPKGVR 660

  Fly   651 -EIKYASTPSFM---LLTTIVFFTFLVGG-IAGIC--CVK----AKSRLM-----EAQMDESHRN 699
             |::...:...:   :|.|.||..|::|. |||:.  |.:    .|:|.:     .||.......
Mouse   661 WEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSG 725

  Fly   700 HFGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLEKELPCKTST 761
            .|.|            :|.|..|......|   |:|..|..|:...:     .||||..|.|
Mouse   726 SFAK------------LNGLFDSPVKEYQQ---NIDSPKLYSNLLTS-----RKELPPNTDT 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	194/492 (39%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/27 (30%)
Sema6d	XP_006499174.1	Sema	49..513	CDD:417757	193/490 (39%)
		PSI	514..>543	CDD:396154	9/29 (31%)
		PHA03247	<922..1069	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820