DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema6b

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001123928.1	Gene:	Sema6b / 20359	MGIID:	1202889	Length:	886	Species:	Mus musculus

Alignment Length:	710	Identity:	217/710 - (30%)
Similarity:	326/710 - (45%)	Gaps:	141/710 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AIPMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAH---FIGNSTDYFKIL----DHNDEFVL- 72
            |:...||:.| |:|.  |..|:..|.|.......|:|   |:|:........    |.|.:.||
Mouse    12 ALSFFLLLLL-GVTY--GLFPEEPPPLSVAPRDYLSHYPVFVGSGPGRLTAAEGAEDLNIQRVLR 73

  Fly    73 ------VGAKDVIYNVSL-----NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
                  :|.:|.:|.|.|     ..|:...:|.|.|..:|.::|.:|||.|.:|.|:::|..||.
Mouse    74 VNRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRD 138

  Fly   127 NGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            ...:.:||:|::.|.|.:|     |.:.....|.:          :.....|||.|.|.:...|:
Mouse   139 ESTLFVCGSNAFNPICANY-----SMDTLQLLGDS----------ISGMARCPYDPKHANVALFS 188

  Fly   192 DGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEV 251
            ||.|::|||.||...|.:|||.     .|||.::|.|...:|.||.|:|...:|.|||||::||.
Mouse   189 DGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEF 253

  Fly   252 MNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSK 315
            ....|.|.||||||||||.|| |....|.|||||||||||||||:..|||:.:||::.:|..|.:
Mouse   254 NYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGR 318

  Fly   316 SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV--- 377
            .:|.|||:|..|:|||||||||:::.:.|.|:|.|:.||..:|.|.||..:|||:||||.|.
Mouse   319 PVILAVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPG 383

  Fly   378 ---EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVI 439
               ..|..|....:||:|.||||:||||::...|.:.:..:.|:||.:||  .|.:.......::
Mouse   384 MQYNASSALPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAV--DVGAGPWGNQTIV 446

  Fly   440 YSGTDDGKVTKFINILSTHPNSTVDRL--KTVVISEMQVL------------PLGTPIRELVIST 490
            :.|::.|.|.||:    ..||::|...  .::.:.|.:..            ..|..:..|.:..
Mouse   447 FLGSEAGTVLKFL----VKPNASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLELDA 507

  Fly   491 SKNSLVVVSDGSLVSVPLHHCSHIVDCL-GCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQ 554
            :...|:......:|.||:..|.....|: .|:..|||.|.|
Mouse   508 ASGGLLAAFPRCVVRVPVARCQLYSGCMKNCIGSQDPYCGW------------------------ 548

  Fly   555 SLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDD 619
                               ||..   |.:.:.|                 |...:.||..:|...
Mouse   549 -------------------APDG---SCIFLRP-----------------GTSATFEQDVSGAST 574

  Fly   620 FGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAGI 679
            .||...|      ..:..:|:|.:....||:.:..:|..:|::...:..|:  ||...|:
Mouse   575 SGLGDCT------GLLRASLSDDRAGLVSVNLLVTSSVAAFVVGAVVSGFS--VGWFVGL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	175/497 (35%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/27 (30%)
Sema6b	NP_001123928.1	Sema_6B	58..526	CDD:200528	174/488 (36%)
		PSI	527..573	CDD:214655	16/108 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731
		PHA03269	708..>875	CDD:165527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820