DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema6a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_006525789.1	Gene:	Sema6a / 20358	MGIID:	1203727	Length:	1048	Species:	Mus musculus

Alignment Length:	837	Identity:	258/837 - (30%)
Similarity:	377/837 - (45%)	Gaps:	150/837 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PMILLITLSGLTIV-AGWMPDVKP-----DLQTKQDKV-LAHFIGNSTDYFKILDHN-----DEF 70
            |..||:.|:.|... ||:..|.:|     ...|||..| :.|..|.:|.....||..     :..
Mouse     3 PAALLLCLTLLHCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRT 67

  Fly    71 VLVGAKDVIYNVSL--NGLKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEV 130
            :.|.|:|.||.|.:  :..:||   .:|.|.|..||.:.|.:||||:.:|||:::|...:.:..:
Mouse    68 LYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTL 132

  Fly   131 LLCGTNSYKPRCRHY---TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFAD 192
            .:||||::.|.||:|   |......|.:|.|                  .|||...|.:...|||
Mouse   133 FVCGTNAFNPSCRNYRVDTLETFGDEFSGMA------------------RCPYDAKHANIALFAD 179

  Fly   193 GHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVM 252
            |.||||||.||...|.:|||.     .|||.::|.|.|.:|.||.|::...|:.|||||:::|..
Mouse   180 GKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYN 244

  Fly   253 NFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKS 316
            ..||.|:.|||:|||||.||... ..|.|||||||||||||||:..|||:.:||::.::....:.
Mouse   245 TMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRD 309

  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVEDSR 381
            ::.|.|:|..|:||||||||:::.||...|.|.||.||...|.|.||..|:||||||| |...|.
Mouse   310 VVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPG-CCAGSS 373

  Fly   382 TLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY-- 435
            :|...|         :||||.||||:||||::..||...:..:.:|||.||    |.:.:|.|
Mouse   374 SLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIA----VDNAAGPYQN 434

  Fly   436 YDVIYSGTDDGKVTKFINIL--STHPNSTVDRLKTVVISEMQVLPLGTP------------IREL 486
            :.|::.|::.|.:.||:..:  |...|.      ::.:.||.|.   .|            |..:
Mouse   435 HTVVFLGSEKGIILKFLARIGSSGFLNG------SLFLEEMNVY---NPEKCSYDGVEDKRIMGM 490

  Fly   487 VISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTK 550
            .:..:..||.|.....::.|||..|.....| ..|::.:||.|.|..::..|.:|:    .....
Mouse   491 QLDRASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVRESGSCAHLS----PLSRL 551

  Fly   551 TYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTM--APPPTEEQKLLYSNVGSSQGNQPSLEQQ 613
            |:.|.:....           .|..|....|||.:  ...|..:.::.::.|   .|:..||...
Mouse   552 TFEQDIERGN-----------TDGLGDCHNSFVALNDISTPLPDYEMSFNRV---YGHASSLYPS 602

  Fly   614 PTGGDDFGLNKITLTS--MDPDDIM--PNLNDPQKSTAS---------VDEIKYASTPSFM---L 662
            .|..|....:......  :|.:|::  |...||..:.:|         :.|....|....:   |
Mouse   603 TTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSNDQLVPVTL 667

  Fly   663 LTTIVFFTFLVG----GIAGIC-CVKAKSRLMEAQMDESHRNH---------------FGKPMQF 707
            |...|...|::|    ||...| |...:..:...|..|....|               || ..|.
Mouse   668 LAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFG-DTQS 731

  Fly   708 KHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLE-KELPCKTSTLT 763
            |.......:..||.:....|...|..:.::.|:        .||: ..||...||.|
Mouse   732 KDPKPEAILTPLMHNGKLATPSNTAKMLIKADQ--------HHLDLTALPTPESTPT 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	185/499 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	7/27 (26%)
Sema6a	XP_006525789.1	Sema_6A	48..513	CDD:200527	183/496 (37%)
Sema6a	XP_006525789.1	PSI	514..>546	CDD:366642	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820