Protein Alignment Sema1b and Sema4f

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_035480.3
• Gene: Sema4f / 20355
• MGIID: 1340055
• Length: 777
• Species: Mus musculus
• Alignment Length: 821
• Identity: 219/821 - (26%)
• Similarity: 349/821 - (42%)
• Gaps: 177/821 - (21%)

  Fly     2 SSKSRPSSAAMLVNAIP---MILLITLSGLTI-VAGWMPDVKPDLQ---TKQDKVLAHFIGNST- 58
            :.:.||......|:..|   .:||:.|:.|:. |.|.:|...|...   ::.|..|..|....|
Mouse     5 AERPRPGPRPPPVSLFPPPSSLLLLLLAMLSAPVCGRVPRSVPRTSLPISEADSYLTRFAAPHTY 69

  Fly    59 DYFKIL-DHNDEFVLVGAKDVIYNVSL--NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLR 120
            :|..:| |.....:.|||:|.|:.::|  :|.|. .|::|...:..|:.|..|||.|.:|||:::
Mouse    70 NYSALLVDPASHTLYVGARDSIFALTLPFSGEKP-RRIDWMVPETHRQNCRKKGKKEDECHNFIQ 133

  Fly   121 VYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHN 185
            :.|:.....:|.|||.::.|:|   ..::|||.:            :|.|....:|.||:.||..
Mouse   134 ILAIANASHLLTCGTFAFDPKC---GVIDVSSFQ------------QVERLESGRGKCPFEPAQR 183

  Fly   186 STYAFADGHLYSATVADFSGGDPLIYR------ENLRTEQYDLKQLNQPDFVGAI---------- 234
            |....|.|.||:|||.:|.|.:|:|.|      :.:|||... ..||.|.||.|:
Mouse   184 SAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLS-SWLNAPAFVAAMVLSPAEWGDE 247

  Fly   235 ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVP--GEFP 297
            :.:..:.|||.|.|..:.::.:....||||||..|.||..:..:.||:||||.|.|..|  |...
Mouse   248 DGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRAS 312

  Fly   298 FYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLP 362
            ....::..:.|...:|: .|.|.:|::.......||||||...||.|..:|.|:..|...:..||
Mouse   313 GVLQDMTELRPQPGAGT-PLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLP 376

  Fly   363 VEREQVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHR 418
            |...:||:||||:|:.:         |.:|....:.||::||||:..|....|||||...:..:
Mouse   377 VMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAY- 440

  Fly   419 LTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINI---LSTHPNSTVDRLKTVVISEMQVLPLG 480
             ..:..| :|.||||..|||:|.||:||.:.:.:.|   ||             |:.::.:.|..
Mouse   441 -LRVVAH-RVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLS-------------VLEDLALFPET 490

  Fly   481 TPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQH 545
            .|:..:.:  ..:.|:|.|...:..|...:|..:..|..|:..|||:|||..:...|...| .:|
Mouse   491 QPVESMKL--YHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHA-GEH 552

  Fly   546 KFGTKTYLQSLNSTKKAAALLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSNVGSSQG 605
                :..:|.:.|...::  |||..|.:.|     ...||..|.:...|:       |...|...
Mouse   553 ----RGMVQDIESADVSS--LCPKEPGEHPVVFEVPVATVGHVVLPCSPS-------SAWASCVW 604

  Fly   606 NQPSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFT 670
            :|||           |:..:|               |::     |.::...||..|
Mouse   605 HQPS-----------GVTSLT---------------PRR-----DGLEVVVTPGAM--------- 629

  Fly   671 FLVGGIAGIC-------CVKAKSRLMEAQMDESHRNH-----------------------FGKPM 705
               |..|..|       .|.|.|.:..:|...::|.|                       .|:..
Mouse   630 ---GAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVGAGLVGFFLGVLAASLTLLLIGRRQ 691

  Fly   706 QFKHQ-------NTGKDINL-LMGSNAYTTTQKTPNLDLEK 738
            |.:.|       ..|.|:.. ..|:.:|:....:|:.:.|:
Mouse   692 QRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDER 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	151/489 (31%)
		PSI	510..>537	CDD:214655	9/26 (35%)
Sema4f	NP_035480.3	Sema_4F	58..517	CDD:200522	153/494 (31%)
		PSI	518..569	CDD:396154	15/57 (26%)
		Sema4F_C	582..777	CDD:437260	34/201 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	703..742		6/30 (20%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11483650	775..777