DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4f

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_035480.3	Gene:	Sema4f / 20355	MGIID:	1340055	Length:	777	Species:	Mus musculus

Alignment Length:	821	Identity:	219/821 - (26%)
Similarity:	349/821 - (42%)	Gaps:	177/821 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKSRPSSAAMLVNAIP---MILLITLSGLTI-VAGWMPDVKPDLQ---TKQDKVLAHFIGNST- 58
            :.:.||......|:..|   .:||:.|:.|:. |.|.:|...|...   ::.|..|..|....|
Mouse     5 AERPRPGPRPPPVSLFPPPSSLLLLLLAMLSAPVCGRVPRSVPRTSLPISEADSYLTRFAAPHTY 69

  Fly    59 DYFKIL-DHNDEFVLVGAKDVIYNVSL--NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLR 120
            :|..:| |.....:.|||:|.|:.::|  :|.|. .|::|...:..|:.|..|||.|.:|||:::
Mouse    70 NYSALLVDPASHTLYVGARDSIFALTLPFSGEKP-RRIDWMVPETHRQNCRKKGKKEDECHNFIQ 133

  Fly   121 VYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHN 185
            :.|:.....:|.|||.::.|:|   ..::|||.:            :|.|....:|.||:.||..
Mouse   134 ILAIANASHLLTCGTFAFDPKC---GVIDVSSFQ------------QVERLESGRGKCPFEPAQR 183

  Fly   186 STYAFADGHLYSATVADFSGGDPLIYR------ENLRTEQYDLKQLNQPDFVGAI---------- 234
            |....|.|.||:|||.:|.|.:|:|.|      :.:|||... ..||.|.||.|:
Mouse   184 SAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLS-SWLNAPAFVAAMVLSPAEWGDE 247

  Fly   235 ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVP--GEFP 297
            :.:..:.|||.|.|..:.::.:....||||||..|.||..:..:.||:||||.|.|..|  |...
Mouse   248 DGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRAS 312

  Fly   298 FYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLP 362
            ....::..:.|...:|: .|.|.:|::.......||||||...||.|..:|.|:..|...:..||
Mouse   313 GVLQDMTELRPQPGAGT-PLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLP 376

  Fly   363 VEREQVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHR 418
            |...:||:||||:|:.:         |.:|....:.||::||||:..|....|||||...:..:
Mouse   377 VMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAY- 440

  Fly   419 LTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINI---LSTHPNSTVDRLKTVVISEMQVLPLG 480
             ..:..| :|.||||..|||:|.||:||.:.:.:.|   ||             |:.::.:.|..
Mouse   441 -LRVVAH-RVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLS-------------VLEDLALFPET 490

  Fly   481 TPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQH 545
            .|:..:.:  ..:.|:|.|...:..|...:|..:..|..|:..|||:|||..:...|...| .:|
Mouse   491 QPVESMKL--YHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHA-GEH 552

  Fly   546 KFGTKTYLQSLNSTKKAAALLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSNVGSSQG 605
                :..:|.:.|...::  |||..|.:.|     ...||..|.:...|:       |...|...
Mouse   553 ----RGMVQDIESADVSS--LCPKEPGEHPVVFEVPVATVGHVVLPCSPS-------SAWASCVW 604

  Fly   606 NQPSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFT 670
            :|||           |:..:|               |::     |.::...||..|
Mouse   605 HQPS-----------GVTSLT---------------PRR-----DGLEVVVTPGAM--------- 629

  Fly   671 FLVGGIAGIC-------CVKAKSRLMEAQMDESHRNH-----------------------FGKPM 705
               |..|..|       .|.|.|.:..:|...::|.|                       .|:..
Mouse   630 ---GAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVGAGLVGFFLGVLAASLTLLLIGRRQ 691

  Fly   706 QFKHQ-------NTGKDINL-LMGSNAYTTTQKTPNLDLEK 738
            |.:.|       ..|.|:.. ..|:.:|:....:|:.:.|:
Mouse   692 QRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDER 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	151/489 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
Sema4f	NP_035480.3	Sema_4F	58..517	CDD:200522	153/494 (31%)
		PSI	518..569	CDD:279745	15/57 (26%)
		Ig	576..655	CDD:299845	23/128 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..742		6/30 (20%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11483650	775..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910