DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4d

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001268809.1	Gene:	Sema4d / 20354	MGIID:	109244	Length:	861	Species:	Mus musculus

Alignment Length:	834	Identity:	224/834 - (26%)
Similarity:	347/834 - (41%)	Gaps:	205/834 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DYFKILDHNDEFVL-VGAKDVIYNV-SLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLR 120
            :|..:|...|:..| |||::.::.| :||..::...:.|..::..:..||.||| .:.:|.||:|
Mouse    49 NYSALLMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIR 113

  Fly   121 VYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHN 185
            |.....:..:.:||||:::|.|.|.              :..:.:: :.:..:.:|.||:.|||:
Mouse   114 VLQPLSSTSLYVCGTNAFQPTCDHL--------------NLTSFKF-LGKSEDGKGRCPFDPAHS 163

  Fly   186 STYAFADGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFV----------GAIER 236
            .|.....|.|||.|..:|.|.:|:|.|.:    |||| |.:..||:|.||          |....
Mouse   164 YTSVMVGGELYSGTSYNFLGSEPIISRNSSHSPLRTE-YAIPWLNEPSFVFADVIQKSPDGPEGE 227

  Fly   237 NGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFD 301
            :..|.|||.|:|:|.....|.:..|||||||.|:||..:..|.|||||||||.||.| :....|:
Mouse   228 DDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQKKWTSFLKARLICSKP-DSGLVFN 291

  Fly   302 EIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GEF-KSQKDSQSH--WL 361
            .:|.:..:...|.|. :.|||||..:|.:..|||||:.:..:.|.|. |:: :|....|||  |:
Mouse   292 ILQDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLATVEAVFSRGKYMQSATVEQSHTKWV 356

  Fly   362 PVEREQVPKPRPGQCVE---------DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHH 417
            .. ...||.||||.|::         .|..|....:.|:|:||||:::|..:..||.|.|.::::
Mouse   357 RY-NGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPKLIKKDVNY 420

  Fly   418 RLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTP 482
              |.|.| .:.::|.|.:|||::..||.|.:.|.: ||:...:         ||.|.|:.....|
Mouse   421 --TQIVV-DRTQALDGTFYDVMFISTDRGALHKAV-ILTKEVH---------VIEETQLFRDSEP 472

  Fly   483 IRELVISTSKNSLVVV--SDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNL----- 540
            :..|::|:.|....|.  |:..:|..||..|.....|..|:..:||.|||......|..|
Mouse   473 VLTLLLSSKKGRKFVYAGSNSGVVQAPLAFCEKHGSCEDCVLARDPYCAWSPAIKACVTLHQEEA 537

  Fly   541 ----------------------ATSQHKF---GT---KTYLQS---------LNSTKKAAA---- 564
                                  :.:||.|   ||   |.:.:|         .|...|||:
Mouse   538 SSRGWIQDMSGDTSSCLDKSKESFNQHFFKHGGTAELKCFQKSNLARVVWKFQNGELKAASPKYG 602

  Fly   565 -----------------------------------LLCPHIPRDAPGAETVSFVTMAPP-PTEEQ 593
                                               ||..|:..       |..|...|| ||.|.
Mouse   603 FVGRKHLLIFNLSDGDSGVYQCLSEERVRNKTVSQLLAKHVLE-------VKMVPRTPPSPTSED 660

  Fly   594 KLLYSN-------VGSSQGNQP-------------SLEQQPTGGDDFGLNKITLTSMDPDDIMPN 638
            .....:       |.|:||:.|             :|..:.:.|          ||.:|..::..
Mouse   661 AQTEGSKITSKMPVASTQGSSPPTPALWATSPRAATLPPKSSSG----------TSCEPKMVINT 715

  Fly   639 LNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLV--------GGIAGICCVKAKSRLM------ 689
            :  ||..:.....:|.:.....|.|...:|..||.        |.:.| .|:|.:|.|:
Mouse   716 V--PQLHSEKTVYLKSSDNRLLMSLLLFIFVLFLCLFSYNCYKGYLPG-QCLKFRSALLLGKKTP 777

  Fly   690 ---EAQMDESHRNHFGKPMQFKHQNTGKDINLLMGSNAYTTTQKTPNLDLEKDR 740
               .:.:::|.:....:|..|..||.......|  ...|.|.|.|....:..||
Mouse   778 KSDFSDLEQSVKETLVEPGSFSQQNGDHPKPAL--DTGYETEQDTITSKVPTDR 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	157/484 (32%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/26 (31%)
Sema4d	NP_001268809.1	Sema_4D	31..501	CDD:200520	156/482 (32%)
		PSI	503..548	CDD:396154	10/44 (23%)
		Ig	563..646	CDD:416386	14/89 (16%)
		Ig strand B	569..577	CDD:409353	3/7 (43%)
		Ig strand C	583..589	CDD:409353	0/5 (0%)
		Ig strand C'	591..594	CDD:409353	1/2 (50%)
		Ig strand D	600..604	CDD:409353	0/3 (0%)
		Ig strand E	607..614	CDD:409353	0/6 (0%)
		Ig strand F	620..629	CDD:409353	0/8 (0%)
		Ig strand G	633..646	CDD:409353	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..709		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..839		11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910