DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4c

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_006495867.1	Gene:	Sema4c / 20353	MGIID:	109252	Length:	943	Species:	Mus musculus

Alignment Length:	675	Identity:	199/675 - (29%)
Similarity:	312/675 - (46%)	Gaps:	103/675 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSRPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKP-------DLQTKQDKVLAHFIGNSTDYF 61
            |.||..:||..:....:|...|.||.|.|....::.|       :|.|    |:..|.......|
Mouse   102 KFRPWVSAMAPHWAVWLLAAGLWGLGIGAEMWWNLVPRKTVSSGELVT----VVRRFSQTGIQDF 162

  Fly    62 KIL---DHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVY 122
            ..|   :|:. .:.|||::.::..|:..|:....:.|.:....:..|..||| ::.:|.|::|..
Mouse   163 LTLTLTEHSG-LLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFL 226

  Fly   123 ALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNST 187
            ....:..:.:|||.:::|:|.:...:..:.:.|         .:|     :.:|.|||.||...|
Mouse   227 QPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRA---------EFE-----DGKGKCPYDPAKGHT 277

  Fly   188 YAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAI---ERNG------ 238
            ....||.|||||:.:|.|.:|:|.|     .:::|| |....||:|.|||:.   |..|
Mouse   278 GLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTE-YLAFWLNEPHFVGSAFVPESVGSFTGDD 341

  Fly   239 -YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDE 302
             .:.|||.|.::|...:.:.|.:|||||||.|.||..:..|.||:||||||.||.| ::..||::
Mouse   342 DKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAP-DWKVYFNQ 405

  Fly   303 IQAISPI-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
            ::|:..: ..|...:..:.||......:..||||.:.::.|...|:|.:|...:....|... .:
Mouse   406 LKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARY-TD 469

  Fly   367 QVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTK--VNLHHRLT 420
            .||.||||.|:.:         |..|....:||||.|||||:.|....|||||.|  .|..|
Mouse   470 PVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTH--- 531

  Fly   421 AIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILS-THPNSTVDRLKTVVISEMQVLPLGTPIR 484
              .|..:|..|.||.|.|::.||.||.:.|.:::.. .|           ::.|:||.. ..|:.
Mouse   532 --VVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIH-----------MVEELQVFD-QEPVE 582

  Fly   485 ELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGT 549
            .||:|.||..|...|...||.:.|..|:....|:.|:..:||.|||::.|..|  :||:..:.|:
Mouse   583 SLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRC--VATTSGRSGS 645

  Fly   550 --KTYLQSLNSTKKAAALLCPHI----PRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQ---G 605
              ..::.:|:::|     :|...    .|..|...||...|....|..    |.||:..:.   |
Mouse   646 FLVQHVANLDTSK-----MCNQYGIKKVRSIPKNITVVSGTDLVLPCH----LSSNLAHAHWTFG 701

  Fly   606 NQPSLEQQPTGGD---DFGLNKITL 627
            :|....:||  |.   |.||..:.:
Mouse   702 SQDLPAEQP--GSFLYDTGLQALVV 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/487 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
Sema4c	XP_006495867.1	Sema_4C	151..607	CDD:200519	150/490 (31%)
		PSI	608..>637	CDD:214655	10/30 (33%)
		Ig	673..757	CDD:386229	15/58 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910