Protein Alignment Sema1b and Sema4b

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_038687.2
• Gene: Sema4b / 20352
• MGIID: 107559
• Length: 823
• Species: Mus musculus
• Alignment Length: 833
• Identity: 229/833 - (27%)
• Similarity: 354/833 - (42%)
• Gaps: 148/833 - (17%)

  Fly     6 RPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHFIGNSTDYFKILDHND-E 69
            |.|.:|:|..|:.::||:.|...|......|.:...|.:::..:......|.::|..:|...| :
Mouse     3 RASRSAVLRRALLLLLLLLLLRTTTTRALGPRISVPLGSEERLIRKFEAENISNYTALLLSQDGK 67

  Fly    70 FVLVGAKDVIY--NVSLNGLK--EIARLEWHSTDADR-ELCALKGKH-EWDCHNYLRVYALRPNG 128
            .:.|||::.::  |.:|:.|.  |...|.| |.|||| :.|:.|||. :.||.||:::.....:.
Mouse    68 TLYVGAREALFALNSNLSFLPGGEYQELLW-SADADRKQQCSFKGKDPKRDCQNYIKILLPLNSS 131

  Fly   129 EVLLCGTNSYKPRCR--HYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            .:|.|||.::.|.|.  |.....::.:|||:.         :..|  .:|.||:.|...||....
Mouse   132 HLLTCGTAAFSPLCAYIHIASFTLAQDEAGNV---------ILED--GKGRCPFDPNFKSTALVV 185

  Fly   192 DGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFVGA----------IERNGYVLF 242
            ||.||:.||:.|.|.||.|.|..    .:||. .|..|..|.||.:          |..:..:.|
Mouse   186 DGELYTGTVSSFQGNDPAISRSQSSRPTKTES-SLNWLQDPAFVASAYVPESLGSPIGDDDKIYF 249

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE-FPF-YFDEIQA 305
            ||.|...|...|...:.||||||||.|.||.....:.|||||||:|.||.|.: ||| ...::..
Mouse   250 FFSETGQEFEFFENTIVSRVARVCKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFT 314

  Fly   306 ISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQV 368
            ::|..:...|:|.|.|||:..:  ...|||:|.|.::|:..||||.:|........|. .|..||
Mouse   315 LNPNPQDWRKTLFYGVFTSQWHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWY-TETHQV 378

  Fly   369 PKPRPGQCVEDS---RTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAV 424
            |.||||.|:.:|   |.:.|.      .:||:|:|.||:..|     |..|..:....|...:||
Mouse   379 PTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV-----RSRLLLLQPRARYQRVAV 438

  Fly   425 HPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIS 489
            | :|..|... |||::.||.||::.|.:.:.|          :..:|.|:|:.|.|.|::.|::.
Mouse   439 H-RVPGLHST-YDVLFLGTGDGRLHKAVTLSS----------RVHIIEELQIFPQGQPVQNLLLD 491

  Fly   490 TSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQ 554
            :....|...|...:|.||:.:||....|..||..:||.|||  ....|:..:..|....::.:.|
Mouse   492 SHGGLLYASSHSGVVQVPVANCSLYPTCGDCLLARDPYCAW--TGSACRLASLYQPDLASRPWTQ 554

  Fly   555 SL----------NSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNV--------G 601
            .:          ||:.| |..|.|..|......:..:..|:|.|       |.||:        |
Mouse   555 DIEGASVKELCKNSSYK-ARFLVPGKPCKQVQIQPNTVNTLACP-------LLSNLATRLWVHNG 611

  Fly   602 SSQGNQPSLEQQPTG-----GDDFGLNKITLTSMD---------------PDDIMPNLNDPQKST 646
            :......|....|||     |...||......|::               .:.:|...|. :..|
Mouse   612 APVNASASCRVLPTGDLLLVGSQQGLGVFQCWSIEEGFQQLVASYCPEVMEEGVMDQKNQ-RDGT 675

  Fly   647 ASVDEIKYASTPS---------------FMLLTTIVFFTFLV----------GGI-----AGICC 681
            ..:......|.|:               |:::.|:..|..::          .|:     .|.|.
Mouse   676 PVIINTSRVSAPAGGRASWGADKSYWNEFLVMCTLFVFAMVLLFLFFLYRHRDGMKLFLKQGECA 740

  Fly   682 -VKAKSRLMEAQMDESHRNHFGKP-MQFKHQNTGKDINLLMGSNAYTTTQKTP 732
             |..|:|.:....:....|..|.| ....|:......:...|...:|.::|.|
Mouse   741 SVHPKTRPIVLPPETRPLNGVGPPSTPLDHRGYQALSDSSPGPRVFTESEKRP 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	161/491 (33%)
		PSI	510..>537	CDD:214655	10/26 (38%)
Sema4b	NP_038687.2	Sema	48..511	CDD:472829	161/493 (33%)
		PSI	512..558	CDD:396154	13/47 (28%)
		Ig_Sema4B_like	579..663	CDD:409456	16/90 (18%)
		Ig strand A	579..585	CDD:409456	1/5 (20%)
		Ig strand B	589..597	CDD:409456	2/7 (29%)
		Ig strand C	603..609	CDD:409456	0/5 (0%)
		Ig strand C'	611..614	CDD:409456	1/2 (50%)
		Ig strand D	620..624	CDD:409456	0/3 (0%)
		Ig strand E	626..632	CDD:409456	1/5 (20%)
		Ig strand F	638..647	CDD:409456	1/8 (13%)
		Ig strand G	650..663	CDD:409456	0/12 (0%)