DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4b

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001347064.1	Gene:	Sema4b / 20352	MGIID:	107559	Length:	823	Species:	Mus musculus

Alignment Length:	833	Identity:	229/833 - (27%)
Similarity:	354/833 - (42%)	Gaps:	148/833 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHFIGNSTDYFKILDHND-E 69
            |.|.:|:|..|:.::||:.|...|......|.:...|.:::..:......|.::|..:|...| :
Mouse     3 RASRSAVLRRALLLLLLLLLLRTTTTRALGPRISVPLGSEERLIRKFEAENISNYTALLLSQDGK 67

  Fly    70 FVLVGAKDVIY--NVSLNGLK--EIARLEWHSTDADR-ELCALKGKH-EWDCHNYLRVYALRPNG 128
            .:.|||::.::  |.:|:.|.  |...|.| |.|||| :.|:.|||. :.||.||:::.....:.
Mouse    68 TLYVGAREALFALNSNLSFLPGGEYQELLW-SADADRKQQCSFKGKDPKRDCQNYIKILLPLNSS 131

  Fly   129 EVLLCGTNSYKPRCR--HYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFA 191
            .:|.|||.::.|.|.  |.....::.:|||:.         :..|  .:|.||:.|...||....
Mouse   132 HLLTCGTAAFSPLCAYIHIASFTLAQDEAGNV---------ILED--GKGRCPFDPNFKSTALVV 185

  Fly   192 DGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFVGA----------IERNGYVLF 242
            ||.||:.||:.|.|.||.|.|..    .:||. .|..|..|.||.:          |..:..:.|
Mouse   186 DGELYTGTVSSFQGNDPAISRSQSSRPTKTES-SLNWLQDPAFVASAYVPESLGSPIGDDDKIYF 249

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE-FPF-YFDEIQA 305
            ||.|...|...|...:.||||||||.|.||.....:.|||||||:|.||.|.: ||| ...::..
Mouse   250 FFSETGQEFEFFENTIVSRVARVCKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFT 314

  Fly   306 ISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQV 368
            ::|..:...|:|.|.|||:..:  ...|||:|.|.::|:..||||.:|........|. .|..||
Mouse   315 LNPNPQDWRKTLFYGVFTSQWHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWY-TETHQV 378

  Fly   369 PKPRPGQCVEDS---RTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAV 424
            |.||||.|:.:|   |.:.|.      .:||:|:|.||:..|     |..|..:....|...:||
Mouse   379 PTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV-----RSRLLLLQPRARYQRVAV 438

  Fly   425 HPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVIS 489
            | :|..|... |||::.||.||::.|.:.:.|          :..:|.|:|:.|.|.|::.|::.
Mouse   439 H-RVPGLHST-YDVLFLGTGDGRLHKAVTLSS----------RVHIIEELQIFPQGQPVQNLLLD 491

  Fly   490 TSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQ 554
            :....|...|...:|.||:.:||....|..||..:||.|||  ....|:..:..|....::.:.|
Mouse   492 SHGGLLYASSHSGVVQVPVANCSLYPTCGDCLLARDPYCAW--TGSACRLASLYQPDLASRPWTQ 554

  Fly   555 SL----------NSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNV--------G 601
            .:          ||:.| |..|.|..|......:..:..|:|.|       |.||:        |
Mouse   555 DIEGASVKELCKNSSYK-ARFLVPGKPCKQVQIQPNTVNTLACP-------LLSNLATRLWVHNG 611

  Fly   602 SSQGNQPSLEQQPTG-----GDDFGLNKITLTSMD---------------PDDIMPNLNDPQKST 646
            :......|....|||     |...||......|::               .:.:|...|. :..|
Mouse   612 APVNASASCRVLPTGDLLLVGSQQGLGVFQCWSIEEGFQQLVASYCPEVMEEGVMDQKNQ-RDGT 675

  Fly   647 ASVDEIKYASTPS---------------FMLLTTIVFFTFLV----------GGI-----AGICC 681
            ..:......|.|:               |:::.|:..|..::          .|:     .|.|.
Mouse   676 PVIINTSRVSAPAGGRASWGADKSYWNEFLVMCTLFVFAMVLLFLFFLYRHRDGMKLFLKQGECA 740

  Fly   682 -VKAKSRLMEAQMDESHRNHFGKP-MQFKHQNTGKDINLLMGSNAYTTTQKTP 732
             |..|:|.:....:....|..|.| ....|:......:...|...:|.::|.|
Mouse   741 SVHPKTRPIVLPPETRPLNGVGPPSTPLDHRGYQALSDSSPGPRVFTESEKRP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	161/491 (33%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/26 (38%)
Sema4b	NP_001347064.1	Sema	48..511	CDD:417757	161/493 (33%)
		PSI	512..558	CDD:396154	13/47 (28%)
		Ig_Sema4B_like	579..663	CDD:409456	16/90 (18%)
		Ig strand B	592..596	CDD:409456	1/3 (33%)
		Ig strand C	604..608	CDD:409456	0/3 (0%)
		Ig strand E	626..629	CDD:409456	1/2 (50%)
		Ig strand F	639..644	CDD:409456	0/4 (0%)
		Ig strand G	656..659	CDD:409456	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910