DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema4a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_006501250.1	Gene:	Sema4a / 20351	MGIID:	107560	Length:	798	Species:	Mus musculus

Alignment Length:	745	Identity:	195/745 - (26%)
Similarity:	309/745 - (41%)	Gaps:	161/745 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDHNDEFVLVGAKDVI--YNVSLNGLKEIAR-LEWHSTDADRELCALKGK-HEWDCHNYLRVYA 123
            :|..:...:.|||::.:  .|:...|:..:.. :.|.:::..:..||.|.| :|..|.|::||..
Mouse   106 LLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLV 170

  Fly   124 LRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188
            ......:..|||.::.|.|   |.:|:..        :..:...:.:.::.:|..|:.|.|..|.
Mouse   171 SYNATHLYACGTFAFSPAC---TFIELQD--------SLLLPILIDKVMDGKGQSPFDPVHKHTA 224

  Fly   189 AFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLN-QPDFVGAIERNGYVLFFFREL 247
            ...||.|||.|:.:|.|.:|::.|     ..|:|:.: |:.|: ...||.||.....|.|||.|.
Mouse   225 VLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIF-LRWLHADASFVAAIPSTQVVYFFFEET 288

  Fly   248 SMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312
            :.|...|.:...||||:|||||.||.....|.||:||||:|.|:.||:.||.......:.| .:|
Mouse   289 ASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLP-ADS 352

  Fly   313 GSKSLIYAVFTT--SVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQ 375
            .|.|.||||||:  .|.....||||||::.||...|.|::|......|.|......:| .||||.
Mouse   353 PSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEV-SPRPGS 416

  Fly   376 CVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIY 440
            |  .....:..|:.|:|:|.||:|.|.   |.|||.|..:.:  |.:||. ..:.|.|:.:.|:|
Mouse   417 C--SMGPSSDKALTFMKDHFLMDEHVV---GTPLLVKSGVEY--TRLAVE-SARGLDGSSHVVMY 473

  Fly   441 SGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVS 505
            .||..|.:.|     :..|..:    ...::.|:|:.|...|:|.|.::.::.::.....|.:..
Mouse   474 LGTSTGSLHK-----AVVPQDS----SAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWR 529

  Fly   506 VPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSL-------------- 556
            ||..:||....|:.|:..:||.||||.::..|..|:.|     ||.:.|.:
Mouse   530 VPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGS-----TKPWKQDMERGNPEWVCTRGPM 589

  Fly   557 -NSTKKAA----------------ALLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSN 599
             .|.::.:                .|.|||:...|.     |...:|         |....:|:
Mouse   590 ARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKIS---------EASATVYN- 644

  Fly   600 VGSSQGNQPSLEQQPTGGDDFGLNKITLTS-----------MDPDDIMPNLNDPQKSTASVDEIK 653
                 |:...|.|...|    ||.:...|.           :|..| .|...||:.:....:.::
Mouse   645 -----GSLLLLPQDGVG----GLYQCVATENGYSYPVVSYWVDSQD-QPLALDPELAGVPRERVQ 699

  Fly   654 YAST---------------PSFMLLTTIV------FFTFLVGGIAGICCVKAK------------ 685
            ...|               |.|:::|.::      ..|.|:....|....:.|
Mouse   700 VPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREK 764

  Fly   686 ---SRLMEAQMDESHR----------NHFG 702
               ||....|..:.||          ||.|
Mouse   765 APLSRDQHLQPSKDHRTSASDVDADNNHLG 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	141/459 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/26 (38%)
Sema4a	XP_006501250.1	Sema	93..533	CDD:387663	141/457 (31%)
		PSI	534..578	CDD:214655	16/48 (33%)
		Ig	603..675	CDD:386229	16/90 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910