DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and Sema3c

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_038685.3	Gene:	Sema3c / 20348	MGIID:	107557	Length:	751	Species:	Mus musculus

Alignment Length:	663	Identity:	183/663 - (27%)
Similarity:	307/663 - (46%)	Gaps:	105/663 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MLVNAIPMILLITLSGLTIVAGWMPDVKPDL------QTKQDKV--LAHFIGNSTDY-FKILDHN 67
            |...||.:::.:.:..:.:.....|..:..|      :||..:.  |:|   ...|| ..::|.:
Mouse     1 MAFRAICVLVGVFICSICVRGSSQPQARVYLTFDELRETKTSEYFSLSH---QQLDYRILLMDED 62

  Fly    68 DEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGK---HEWDCHNYLRVYALRPNG 128
            .:.:.||:||.|.::::|.: :|...:.|.::....|.|.:.||   |  .|.|::||.......
Mouse    63 QDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECKMAGKDPTH--GCGNFVRVIQTFNRT 125

  Fly   129 EVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYAFAD 192
            .:.:||:.::.|.|.:......|.::.          :.:....|: :|.|.::|..|:.....:
Mouse   126 HLYVCGSGAFSPVCTYLNRGRRSEDQV----------FMIDSKCESGKGRCSFNPNVNTVSVMIN 180

  Fly   193 GHLYSATVADFSGGDPLIY-----RENLRTEQYDLKQLNQPDFV-------GAIERNGYVLFFFR 245
            ..|:|....||.|.|..|:     |..:||:|::.|.|::|.||       |....:..|.|||:
Mouse   181 EELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFK 245

  Fly   246 ELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF--PFYFDEIQAISP 308
            |...:.....|.::|.:||:|.||.||..|....||:||||||.|||..|.  ..:|||::.:..
Mouse   246 ERLTDNNRSTKQIHSMIARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFL 310

  Fly   309 I-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPR 372
            : .::...:|:|.:||||.:...|||||.:::.||...|:|.| :.|:..:|.|...:.::|.||
Mouse   311 LETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPF-AHKEGPNHQLISYQGRIPYPR 374

  Fly   373 PGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVK 429
            ||.|        :..::......|.||:|||||..::..:|.|||:.::...::.|.||| .:|.
Mouse   375 PGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAV-DRVN 438

  Fly   430 SLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNS 494
            :..|.|: |::.|||.|.|.|.: :|.|:.:::.:    :::.|::|.....||..:.||:.|..
Mouse   439 AADGRYH-VLFLGTDRGTVQKVV-VLPTNSSASGE----LILEELEVFKNHVPITTMKISSKKQQ 497

  Fly   495 LVVVSDGSLVSVPLHHCSHI--VDCLGCLSLQDPICAWDLQTHECK------------------N 539
            |.|.|:..:..|.||.| ||  ..|..|...:||.||||  .|.|.                  |
Mouse   498 LYVSSNEGVSQVSLHRC-HIYGTACADCCLARDPYCAWD--GHSCSRFYPTGKRRSRRQDVRHGN 559

  Fly   540 LATSQHKFGTKTYLQSL---------NSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL 595
            ..|....|..|.|..:.         |||    .|.|      ||.:...|...:.....:.:|.
Mouse   560 PLTQCRGFNLKAYRNAAEIVQYGVRNNST----FLEC------APKSPQASIKWLLQKDKDRRKE 614

  Fly   596 LYSN---VGSSQG 605
            :..|   :.:|||
Mouse   615 VKLNERIIATSQG 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	143/484 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	12/28 (43%)
Sema3c	NP_038685.3	Sema_3C	45..514	CDD:200512	145/491 (30%)
		PSI	513..550	CDD:214655	13/39 (33%)
		Ig_Semaphorin_classIII	575..664	CDD:143279	13/63 (21%)
		IG_like	579..653	CDD:214653	13/59 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910