DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and Sema3a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001230001.1	Gene:	Sema3a / 20346	MGIID:	107558	Length:	772	Species:	Mus musculus

Alignment Length:	684	Identity:	196/684 - (28%)
Similarity:	303/684 - (44%)	Gaps:	113/684 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IGNSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEW-DCH 116
            :.||:.|.. :||.....:.|||||.|::.:|..:|:..::.|..:...|:.|...||... :|.
Mouse    51 LANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECA 115

  Fly   117 NYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYS 181
            |:::|........:..|||.::.|.|.:.        |.|.....:..:.:.|.....:|..||.
Mouse   116 NFIKVLEAYNQTHLYACGTGAFHPICTYI--------EVGHHPEDNIFKLQDSHFENGRGKSPYD 172

  Fly   182 PAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGA-------I 234
            |...:.....||.|||.|.|||.|.|..|:|     ..:||||:|.:.||.|.|:.|       .
Mouse   173 PKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDN 237

  Fly   235 ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FP 297
            ..:..|.|||||.:::..:.|||.::|:.::||||.||..|....||:||||||.|||||.  ..
Mouse   238 PEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGID 302

  Fly   298 FYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWL 361
            .:|||:|.:..:.....|: ::|.|||||.|...|||||.:::.|:...|.|.:..:......|:
Mouse   303 THFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWV 367

  Fly   362 PVEREQVPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRL 419
            |.: .:||.||||.|       .:.::.|....:.|.::||.|...|..::.||::.|.:::::.
Mouse   368 PYQ-GRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQF 431

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIR 484
            |.|.| .:|.:..| .|||::.|||.|.|.|.:::    |..|...|:.|::.||.|....|.|.
Mouse   432 TQIVV-DRVDAEDG-QYDVMFIGTDVGTVLKVVSV----PKETWHDLEEVLLEEMTVFREPTTIS 490

  Fly   485 ELVISTSKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQ--------------- 533
            .:.:||.:..|.:.|...:..:|||.|. :...|..|...:||.||||..
Mouse   491 AMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRR 555

  Fly   534 ---------THECKNLATSQHKFG-------------TKTYL---------------QSLNSTKK 561
                     || |.:|....:..|             :.|:|               |..|..:|
Mouse   556 QDIRNGDPLTH-CSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRK 619

  Fly   562 AAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNKIT 626
            ....:..||.|                 ||:..||.|......||.  |......|....|.|:|
Mouse   620 EEIRMGDHIIR-----------------TEQGLLLRSLQKKDSGNY--LCHAVEHGFMQTLLKVT 665

  Fly   627 LTSMDPDDIMPNLN-DPQKSTASVDEIKYASTPS 659
            |..:|.:.:...|: |.....:.:.|:..:.|||
Mouse   666 LEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	154/479 (32%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/51 (22%)
Sema3a	NP_001230001.1	Sema_3A	26..518	CDD:200510	154/481 (32%)
		PSI	516..>552	CDD:214655	9/35 (26%)
		Ig_Sema3	580..671	CDD:409455	21/109 (19%)
		Ig strand B	594..598	CDD:409455	2/3 (67%)
		Ig strand C	606..610	CDD:409455	0/3 (0%)
		Ig strand E	633..637	CDD:409455	0/3 (0%)
		Ig strand F	647..652	CDD:409455	2/6 (33%)
		Ig strand G	664..667	CDD:409455	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..772
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910