DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and adt-2

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001024532.2	Gene:	adt-2 / 181022	WormBaseID:	WBGene00000083	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	83/428 - (19%)
Similarity:	126/428 - (29%)	Gaps:	152/428 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ITLSGLTIVAGWMPDVKPDLQ---------TKQDKVLAHFI---GNS---TDYFKILDHN----- 67
            :||.....:..:.|...|.|.         |:|...||.::   ||:   .|.|.....|
Worm   244 LTLLNNIQIMYYQPTASPPLTFRVIRYEVLTRQPSALAGYLHNHGNAQMYLDRFCRYQRNLAVRD 308

  Fly    68 -DEFVLVGAKDVIYNVSLNGLKEIARLE-----WHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
             |..:::...|:........:..||||:     |::       |.|
Worm   309 WDHAIMLTGYDIHRGAGSRSISGIARLDGMCDPWNT-------CTL------------------- 347

  Fly   127 NGEVLLCGTNSYKPRCRHYTPVEVSSEEAG-SAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAF 190
             .|.|            .:|...:.:.|.| |.|..|...|..|:.:.:..|.| .....||.:.
Worm   348 -AEGL------------DFTSAFIGTHELGHSVGMRHDEPYCQSKHIMSSSLGP-GKVTWSTCSL 398

  Fly   191 ADGHLYSATVADFSGGDPL-------------------IYRENLRTEQYDLKQLNQPDFVGAIER 236
            .|.|.:...: |..|.:.|                   ||..||:.|              .:..
Worm   399 RDYHQFLQRL-DGRGKNCLRVSNMPNKLEISSNVKPGQIYDANLQCE--------------LMHG 448

  Fly   237 NGYVLFFFRELSMEVM---------NFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSV 292
            |||.....|:.|.:.:         :||:.:.|..|      ..|.:.....|     .:|...|
Worm   449 NGYQQVTPRQDSYDGICYMMWCGQSSFGRIITSHPA------LEGTFCGPSKW-----CQLGRCV 502

  Fly   293 PGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGS------AVCA-FNVDDILAAFDGEF 350
            |      :.....|.|.|:.     :..|.||..:.|.||      .:|: ...:.||.
Worm   503 P------WTGTNEIQPTVQH-----VAPVVTTLPSRIDGSWSGWGATICSQCTCNGILG------ 550

  Fly   351 KSQKDSQSHWLPVEREQVPKPRPGQCVEDSRTLTSIAV 388
                   |..|.:.|.....|.|.....|....||.||
Worm   551 -------SVGLAIARRTCSAPYPANGGSDCVGSTSRAV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	74/384 (19%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655
adt-2	NP_001024532.2	Pep_M12B_propep	52..163	CDD:307618
		ZnMc	211..417	CDD:320741	41/213 (19%)
		TSP1	705..751	CDD:214559
		TSP1	760..810	CDD:214559
		TSP1	816..860	CDD:214559
		TSP1	866..910	CDD:214559
		TSP1	918..963	CDD:214559
		TSP1	969..1015	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910