DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and AgaP_AGAP006634

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_316666.4	Gene:	AgaP_AGAP006634 / 1277221	VectorBaseID:	AGAP006634	Length:	718	Species:	Anopheles gambiae

Alignment Length:	512	Identity:	186/512 - (36%)
Similarity:	273/512 - (53%)	Gaps:	60/512 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YFK--ILDHNDEFVLVGAKDVIYNVSLNGLK----EIARLEWHSTDADRELCALKGKHE-WDCHN 117
            |::  .||...:.:.|||.|.::.::|..:.    |...:....|.:|...|..|||.| :||.|
Mosquito    62 YYRTFYLDEERDTLYVGAMDRVFKLNLKNVSMTSCERDTIVLDPTSSDIRNCVSKGKSEMFDCKN 126

  Fly   118 YLRVYALRPNGEVL-LCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGL---- 177
            ::||.....:|..| :||||::.|:           :....:...|..|.|.   |...||
Mosquito   127 HIRVIQPMDSGNRLYICGTNAHNPK-----------DLVIYSNLTHLPRSEY---VPGIGLGIAK 177

  Fly   178 CPYSPAHNSTYAFAD-GH------LYSATVADFSGGDPLIYRENL-------------RTEQYDL 222
            |||.|..|||..:.: |:      |||.|.|:|:..|.:|:|.:|             ||.:||.
Mosquito   178 CPYDPYDNSTAIYVEQGNPGDLPALYSGTNAEFTKADTVIFRTDLYNMTTGKKVFNFKRTLKYDS 242

  Fly   223 KQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKAR 287
            |.|::|:|||:.:...:|.|||||.::|.:|.|||||||||||||.|.||.....::|.::||||
Mosquito   243 KWLDKPNFVGSFDIGEHVYFFFRETAVEYINCGKAVYSRVARVCKKDTGGKNILNQNWATYLKAR 307

  Fly   288 LNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKS 352
            :|||:.|||||||:|||.:..:  ...|:..||.||||.|.:.|||||:|::::|..||.|:||.
Mosquito   308 INCSISGEFPFYFNEIQDVYQL--PTDKTKFYATFTTSTNGLVGSAVCSFDINEIHGAFAGKFKE 370

  Fly   353 QKDSQSHWLPVEREQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHH 417
            |..|.|.||||...::|:||||.||.|:.||....:|||::||||::||...|..|:..|.:|
Mosquito   371 QASSNSAWLPVLNSKIPEPRPGTCVNDTSTLPDSVLNFIRSHPLMDKAVNHEHNNPVYYKRDL-- 433

  Fly   418 RLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTP 482
            ..|.:.|......:....|.|.|.||:.|::.|.:..|....:.:    |.:.|.|   :.....
Mosquito   434 VFTKLVVDKIKIEILSQEYTVFYIGTNAGRIYKIVQYLRNGESKS----KLLDIFE---IAQNEA 491

  Fly   483 IRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVD-CLGCLSLQDPICAWDLQTHECK 538
            |:.:.:|..:.||.|.:|..:..:.|..|:...| |..|  ::||.|.||..|..||
Mosquito   492 IQVMELSQKRKSLYVATDYRIKQIDLAMCNRRYDNCFRC--VKDPYCGWDKDTSTCK 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	174/482 (36%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)
AgaP_AGAP006634	XP_316666.4	Sema_2A	62..518	CDD:200499	173/480 (36%)
		Ig_Semaphorin_C	568..659	CDD:143180
		IG_like	571..656	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810