DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and AgaP_AGAP005742

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_001688723.1	Gene:	AgaP_AGAP005742 / 1276412	VectorBaseID:	AGAP005742	Length:	769	Species:	Anopheles gambiae

Alignment Length:	781	Identity:	348/781 - (44%)
Similarity:	478/781 - (61%)	Gaps:	86/781 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PDLQTKQDKVLAHFIGNSTDYFKILDHNDEFVLVGAKDVIYNVSLNGLKEI--ARLEWHSTDADR 102
            |.:....:..:..|.||||||||:||.|::::|:||::.:||:|::.|.|:  .|:.|.|:||.|
Mosquito    14 PKIAIVGNATVPSFFGNSTDYFKLLDANEQYILIGARNAVYNISIDRLVELPGQRISWPSSDAHR 78

  Fly   103 ELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYE 167
            |||.||||||.||.||:||:|......:::|||||:||.||:|..:..:.          ::.|:
Mosquito    79 ELCTLKGKHEQDCQNYIRVFARINANRIMVCGTNSFKPLCRYYNVLPGNG----------SLVYD 133

  Fly   168 VSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRENLRTEQYDLKQLNQPDFVG 232
             :.::||||.|||:|.|||||.:.||.|||||||||||.|.|||||..||||:|.||||||.||.
Mosquito   134 -NNELEAQGRCPYNPQHNSTYVYTDGQLYSATVADFSGADALIYREPQRTEQFDSKQLNQPAFVS 197

  Fly   233 AIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFP 297
            |||.||||:||:||::||.||.|||:||||:||||||:||||.....||||||||||||:|||:|
Mosquito   198 AIEYNGYVMFFYREVAMEYMNCGKAIYSRVSRVCKNDKGGPYPFQDKWTSFLKARLNCSIPGEYP 262

  Fly   298 FYFDEIQAISPIVESGS-----KSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQ 357
            |||||:||.:..: ||:     ..:||.:.||..|||.|||||||:|:||:.||:|.||:|:|..
Mosquito   263 FYFDELQATTNAI-SGTYGGVRNKIIYGIMTTPENAIGGSAVCAFSVEDIMEAFEGPFKAQRDIH 326

  Fly   358 SHWLPVEREQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAI 422
            |:||.|....||:||||:||:|||||....|||:|.:.||:.:||:||.||:.|:|:|::||:||
Mosquito   327 SNWLQVPPSAVPEPRPGKCVDDSRTLPKALVNFVKTNNLMDSSVPSVHSRPVFTRVSLYYRLSAI 391

  Fly   423 AVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELV 487
            ||.||||:|.|..||||:.||:||||.||:||||.   :|.|.::||||||.|..|.||.|.|:.
Mosquito   392 AVDPQVKALDGQRYDVIFVGTNDGKVIKFVNILSA---NTSDDVRTVVISETQAFPPGTKINEMT 453

  Fly   488 ISTSKNSLVVVSDGSLVSVPLHHCSH--IVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGT- 549
            ||....:|:|:|.|.::|:|||.|:.  ...|..||.||||.||||....:||.: ...|..|.
Mosquito   454 ISKKNAALIVISSGKIISLPLHTCNEHSFKTCRKCLDLQDPYCAWDDLNRDCKPI-DEVHASGAP 517

  Fly   550 -KTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNV-GSSQGNQP--SL 610
             ..:.|.|:..:  ...:|.......|...|.           |...:|:.| ||....:|  |.
Mosquito   518 IDQFYQRLDGER--IGEICRKYDHQEPTVHTY-----------EDNDVYTRVDGSGAVEKPDKSF 569

  Fly   611 EQQ-------------PTGGDDFGLNKITLTSMDPDD----IMPNLNDPQKSTASVDEIKYASTP 658
            :|:             ..|.:|.. |:|:::|::.|:    |:..|....|....|.:...::||
Mosquito   570 DQRNVLIVHANHGTVSSVGPEDID-NEISMSSVEGDEQTNRIINTLQYQPKPDTFVKQNVLSATP 633

  Fly   659 SFMLLTTIVFFTFLVGGIAGICCVKAKS-RLMEAQMDESHRNHF----GKPMQFKHQ--NTGKDI 716
            :  |::.::.|...|....|:.|:..:. .|.:.|....|||..    ||.:....|  .:|||:
Mosquito   634 N--LISLLLGFIVTVMVSVGVGCLFMRHLMLKKGQGGCEHRNQLHWQSGKSLSMLSQTRTSGKDV 696

  Fly   717 NLLMG-SNAYTTTQKT--------------PNLDLE-KDRSHECKNSTEHLEKELPCKTSTLTKV 765
            ||||. :|.|.|.|:.              .|:|.: ||||.|||||||:|||::.....||.|.
Mosquito   697 NLLMNTTNQYHTQQQAIVQQLQQHHQNNCKDNIDFDYKDRSVECKNSTENLEKDISKGMGTLQKT 761

  Fly   766 K 766
            :
Mosquito   762 R 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	262/462 (57%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	12/28 (43%)
AgaP_AGAP005742	XP_001688723.1	Sema_1A	29..477	CDD:200498	262/462 (57%)
AgaP_AGAP005742	XP_001688723.1	PSI	480..>505	CDD:214655	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	499	1.000	Domainoid score	I1223
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H122940
Inparanoid	1	1.050	627	1.000	Inparanoid score	I2248
OMA	1	1.010	-	-		QHG28691
OrthoDB	1	1.010	-	-		D231201at33208
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		oto110006
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
TreeFam	0	0.000	Not matched by this tool.
	11	11.080