DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA3C

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001337049.1	Gene:	SEMA3C / 10512	HGNCID:	10725	Length:	769	Species:	Homo sapiens

Alignment Length:	686	Identity:	189/686 - (27%)
Similarity:	312/686 - (45%)	Gaps:	115/686 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDL------QTKQDKV--LAHFIGNSTDY-FKIL 64
            |..|....|.:::.:.:..:.:.....|..:..|      :||..:.  |:|   :..|| ..::
Human    16 SEEMAFRTICVLVGVFICSICVKGSSQPQARVYLTFDELRETKTSEYFSLSH---HPLDYRILLM 77

  Fly    65 DHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGK---HEWDCHNYLRVYALR 125
            |.:.:.:.||:||.|.::::|.: :|...:.|.::....|.|.:.||   |  .|.|::||....
Human    78 DEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTH--GCGNFVRVIQTF 140

  Fly   126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYA 189
            ....:.:||:.::.|.|.:......|.::.          :.:....|: :|.|.::|..|:...
Human   141 NRTHLYVCGSGAFSPVCTYLNRGRRSEDQV----------FMIDSKCESGKGRCSFNPNVNTVSV 195

  Fly   190 FADGHLYSATVADFSGGDPLIY-----RENLRTEQYDLKQLNQPDFV-------GAIERNGYVLF 242
            ..:..|:|....||.|.|..|:     |..:||:|::.|.|::|.||       |....:..|.|
Human   196 MINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYF 260

  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF--PFYFDEIQA 305
            ||:|...:.....|.::|.:||:|.||.||..|....||:||||||.|||..|.  ..:|||::.
Human   261 FFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELED 325

  Fly   306 ISPI-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVP 369
            :..: .::...:|:|.:||||.:...|||||.:::.||...|:|.| :.|:..:|.|...:.::|
Human   326 VFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPF-AHKEGPNHQLISYQGRIP 389

  Fly   370 KPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHP 426
            .||||.|        :..::......|.||:|||||..::..:|.|||:.::...::.|.||| .
Human   390 YPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAV-D 453

  Fly   427 QVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTS 491
            :|.:..|.|: |::.|||.|.|.|.: :|.|: ||....|   ::.|::|.....||..:.||:.
Human   454 RVNAADGRYH-VLFLGTDRGTVQKVV-VLPTN-NSVSGEL---ILEELEVFKNHAPITTMKISSK 512

  Fly   492 KNSLVVVSDGSLVSVPLHHCSHI--VDCLGCLSLQDPICAWDLQTHECK---------------- 538
            |..|.|.|:..:..|.||.| ||  ..|..|...:||.||||  .|.|.
Human   513 KQQLYVSSNEGVSQVSLHRC-HIYGTACADCCLARDPYCAWD--GHSCSRFYPTGKRRSRRQDVR 574

  Fly   539 --NLATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTE---------- 591
              |..|....|..|.|       :.||.::...:..:      .:|:..||...:
Human   575 HGNPLTQCRGFNLKAY-------RNAAEIVQYGVKNN------TTFLECAPKSPQASIKWLLQKD 626

  Fly   592 -----EQKLLYSNVGSSQGNQPSLEQQPTGGDDFGL 622
                 |.||....:.:|||    |..:...|.|.||
Human   627 KDRRKEVKLNERIIATSQG----LLIRSVQGSDQGL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	146/484 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	12/28 (43%)
SEMA3C	NP_001337049.1	Sema_3C	63..532	CDD:200512	148/491 (30%)
		PSI	531..568	CDD:214655	13/39 (33%)
		Ig_Semaphorin_classIII	593..682	CDD:143279	16/76 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910