DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1b and SEMA4B

DIOPT Version :10

Sequence 1:NP_611244.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster
Sequence 2:NP_001310963.1 Gene:SEMA4B / 10509 HGNCID:10730 Length:847 Species:Homo sapiens


Alignment Length:678 Identity:196/678 - (28%)
Similarity:300/678 - (44%) Gaps:129/678 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PMILLITLSGLTIV----AGW--MPDVKPDLQTKQDKVL---AHFIGNSTDYFKILDHNDEFVLV 73
            |::||:.|  |.::    ..|  .|.:...|.:::...|   |..|.|.|..  :|..:...:.|
Human    24 PLLLLLLL--LLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTAL--LLSRDGRTLYV 84

  Fly    74 GAKDVIYNVSLN------GLKEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVL 131
            ||::.::.:|.|      |  |...|.|.:....::.|:.|||. :.||.||:::........:.
Human    85 GAREALFALSSNLSFLPGG--EYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLF 147

  Fly   132 LCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRD-------VEAQGLCPYSPAHNSTYA 189
            .|||.::.|.|.:     ::.|           .:.::||       .:.:|.||:.|...||..
Human   148 TCGTAAFSPMCTY-----INME-----------NFTLARDEKGNVLLEDGKGRCPFDPNFKSTAL 196

  Fly   190 FADGHLYSATVADFSGGDPLIYR-ENLR---TEQYDLKQLNQPDFV---------GAIE-RNGYV 240
            ..||.||:.||:.|.|.||.|.| ::||   ||. .|..|..|.||         |::: .:..:
Human   197 VVDGELYTGTVSSFQGNDPAISRSQSLRPTKTES-SLNWLQDPAFVASAYIPESLGSLQGDDDKI 260

  Fly   241 LFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE-FPF-YFDEI 303
            .|||.|...|...|...:.||:||:||.|.||.....:.|||||||:|.||.|.: ||| ...::
Human   261 YFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDV 325

  Fly   304 QAISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
            ..:||..:....:|.|.|||:..:  ...|||||.|.:.|:...|.|.:|........|..| ..
Human   326 FTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTV-TH 389

  Fly   367 QVPKPRPGQCVEDS---RTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAI 422
            .||.||||.|:.:|   |.:.|.      .:||:|:|.||:   ..|..|.||.:...  |...:
Human   390 PVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD---GQVRSRMLLLQPQA--RYQRV 449

  Fly   423 AVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELV 487
            ||| :|..|... |||::.||.||::.|.:   |..|       :..:|.|:|:...|.|::.|:
Human   450 AVH-RVPGLHHT-YDVLFLGTGDGRLHKAV---SVGP-------RVHIIEELQIFSSGQPVQNLL 502

  Fly   488 ISTSKNS----------LVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLAT 542
            :.|.:.|          |...|...:|.||:.:||....|..||..:||.|||  ....||:::.
Human   503 LDTHRVSRPTRNPGRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAW--SGSSCKHVSL 565

  Fly   543 SQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL-----------L 596
            .|.:..|:.::|.:...  :|..||     .|....:.|||.....|.|:.:.           |
Human   566 YQPQLATRPWIQDIEGA--SAKDLC-----SASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPL 623

  Fly   597 YSNV--------GSSQGNQPSLEQQPTG 616
            .||:        |:......|....|||
Human   624 LSNLATRLWLRNGAPVNASASCHVLPTG 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1bNP_611244.1 Sema_1A 55..511 CDD:200498 153/506 (30%)
PSI 510..>537 CDD:214655 10/26 (38%)
SEMA4BNP_001310963.1 Sema 61..534 CDD:472829 155/511 (30%)
PSI 535..581 CDD:396154 15/47 (32%)
Ig_Sema4B_like 604..687 CDD:409456 10/48 (21%)
Ig strand A 604..610 CDD:409456 2/5 (40%)
Ig strand B 614..622 CDD:409456 0/7 (0%)
Ig strand C 628..634 CDD:409456 0/5 (0%)
Ig strand C' 636..639 CDD:409456 1/2 (50%)
Ig strand D 645..649 CDD:409456 0/3 (0%)
Ig strand E 651..657 CDD:409456 1/1 (100%)
Ig strand F 662..671 CDD:409456
Ig strand G 674..687 CDD:409456
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..815
Blue background indicates that the domain is not in the aligned region.

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