DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA4B

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001310963.1	Gene:	SEMA4B / 10509	HGNCID:	10730	Length:	847	Species:	Homo sapiens

Alignment Length:	678	Identity:	196/678 - (28%)
Similarity:	300/678 - (44%)	Gaps:	129/678 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PMILLITLSGLTIV----AGW--MPDVKPDLQTKQDKVL---AHFIGNSTDYFKILDHNDEFVLV 73
            |::||:.|  |.::    ..|  .|.:...|.:::...|   |..|.|.|..  :|..:...:.|
Human    24 PLLLLLLL--LLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTAL--LLSRDGRTLYV 84

  Fly    74 GAKDVIYNVSLN------GLKEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVL 131
            ||::.::.:|.|      |  |...|.|.:....::.|:.|||. :.||.||:::........:.
Human    85 GAREALFALSSNLSFLPGG--EYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLF 147

  Fly   132 LCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRD-------VEAQGLCPYSPAHNSTYA 189
            .|||.::.|.|.:     ::.|           .:.::||       .:.:|.||:.|...||..
Human   148 TCGTAAFSPMCTY-----INME-----------NFTLARDEKGNVLLEDGKGRCPFDPNFKSTAL 196

  Fly   190 FADGHLYSATVADFSGGDPLIYR-ENLR---TEQYDLKQLNQPDFV---------GAIE-RNGYV 240
            ..||.||:.||:.|.|.||.|.| ::||   ||. .|..|..|.||         |::: .:..:
Human   197 VVDGELYTGTVSSFQGNDPAISRSQSLRPTKTES-SLNWLQDPAFVASAYIPESLGSLQGDDDKI 260

  Fly   241 LFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE-FPF-YFDEI 303
            .|||.|...|...|...:.||:||:||.|.||.....:.|||||||:|.||.|.: ||| ...::
Human   261 YFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDV 325

  Fly   304 QAISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
            ..:||..:....:|.|.|||:..:  ...|||||.|.:.|:...|.|.:|........|..| ..
Human   326 FTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTV-TH 389

  Fly   367 QVPKPRPGQCVEDS---RTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAI 422
            .||.||||.|:.:|   |.:.|.      .:||:|:|.||:   ..|..|.||.:...  |...:
Human   390 PVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD---GQVRSRMLLLQPQA--RYQRV 449

  Fly   423 AVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELV 487
            ||| :|..|... |||::.||.||::.|.:   |..|       :..:|.|:|:...|.|::.|:
Human   450 AVH-RVPGLHHT-YDVLFLGTGDGRLHKAV---SVGP-------RVHIIEELQIFSSGQPVQNLL 502

  Fly   488 ISTSKNS----------LVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLAT 542
            :.|.:.|          |...|...:|.||:.:||....|..||..:||.|||  ....||:::.
Human   503 LDTHRVSRPTRNPGRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAW--SGSSCKHVSL 565

  Fly   543 SQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL-----------L 596
            .|.:..|:.::|.:...  :|..||     .|....:.|||.....|.|:.:.           |
Human   566 YQPQLATRPWIQDIEGA--SAKDLC-----SASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPL 623

  Fly   597 YSNV--------GSSQGNQPSLEQQPTG 616
            .||:        |:......|....|||
Human   624 LSNLATRLWLRNGAPVNASASCHVLPTG 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	153/506 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/26 (38%)
SEMA4B	NP_001310963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910