DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA4D

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001358123.1	Gene:	SEMA4D / 10507	HGNCID:	10732	Length:	862	Species:	Homo sapiens

Alignment Length:	839	Identity:	217/839 - (25%)
Similarity:	356/839 - (42%)	Gaps:	223/839 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDHNDEFVLVGAKDVIYNV-SLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYALR 125
            :|..:.:.:.:||::.::.| :||..::...:.|..::..:..||.||| .:.:|.||:||....
Human    54 LLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPL 118

  Fly   126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAF 190
            ....:.:||||:::|.|.|.              :..:.:: :.::.:.:|.||:.|||:.|...
Human   119 SATSLYVCGTNAFQPACDHL--------------NLTSFKF-LGKNEDGKGRCPFDPAHSYTSVM 168

  Fly   191 ADGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFV-------------GAIERNG 238
            .||.|||.|..:|.|.:|:|.|.:    |||| |.:..||:|.||             |..:|
Human   169 VDGELYSGTSYNFLGSEPIISRNSSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDR-- 230

  Fly   239 YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEI 303
             |.|||.|:|:|.....:.:..|:|||||.|:||..:..|.|||||||||.||.| :....|:.:
Human   231 -VYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVL 293

  Fly   304 QAISPIVESGSK-SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GEF-KSQKDSQSH--WLPV 363
            :.:..:...|.| .:.||:||..:|.:..|||||:|:......|. |:: :|....|||  |:..
Human   294 RDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRY 358

  Fly   364 EREQVPKPRPGQCVE---------DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRL 419
             ...|||||||.|::         .|..|....:.|:|:||||:::|..:..||.|.|.::::
Human   359 -NGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY-- 420

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINI-LSTHPNSTVDRLKTVVISEMQVLPLGTPI 483
            |.|.| .:.::|.|..|||::..||.|.:.|.|:: .:.|           :|.|.|:.....|:
Human   421 TQIVV-DRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH-----------IIEETQLFQDFEPV 473

  Fly   484 RELVISTSKNSLVVV--SDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHEC--------- 537
            :.|::|:.|.:..|.  |:..:|..||..|.....|..|:..:||.|||...|..|
Human   474 QTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESP 538

  Fly   538 ----------------------------KNLATSQHKFGTKTYLQSL-----NSTKKAAA----- 564
                                        |:..|::.|...|:.|..:     |...||.:
Human   539 SRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGL 603

  Fly   565 -----LLCPHIPRDAPG-------------------AETVSFVTMAPPP----------TEEQKL 595
                 ||..::.....|                   |:.|..|.:.|.|          ||..::
Human   604 MGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRI 668

  Fly   596 LYS-NVGSSQGNQ---PSLEQQPTGGDDFGLNKITL--------TSMDPDDIMPNLNDPQKSTAS 648
            ... .|.|:||:.   |:::...:|.       |||        ||.:|..::..:  ||..:..
Human   669 ATKVLVASTQGSSPPTPAVQATSSGA-------ITLPPKPAPTGTSCEPKIVINTV--PQLHSEK 724

  Fly   649 VDEIKYASTPSFMLLTTIVFFTFLVGGIAGIC--------------CVKAKSRLMEAQ------- 692
            ...:|  |:.:.:|::..:||..|.     :|              |:|.:|.|:..:
Human   725 TMYLK--SSDNRLLMSLFLFFFVLF-----LCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDF 782

  Fly   693 --MDESHRNHFGKPMQFKHQN---------TGKDINLLMGSNAYTTTQKTPNLDLEKDR 740
              .::|.:....:|..|..||         ||           |.|.|.|....:..||
Human   783 CDREQSLKETLVEPGSFSQQNGEHPKPALDTG-----------YETEQDTITSKVPTDR 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	151/483 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
SEMA4D	NP_001358123.1	Sema_4D	31..501	CDD:200520	150/481 (31%)
		PSI	503..554	CDD:214655	10/50 (20%)
		Ig_Sema4D_like	559..645	CDD:143281	13/85 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..837		12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910