Protein Alignment Sema1b and SEMA4D

DIOPT Version :10

• Sequence 1: NP_611244.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_006369.3
• Gene: SEMA4D / 10507
• HGNCID: 10732
• Length: 862
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 217/839 - (25%)
• Similarity: 356/839 - (42%)
• Gaps: 223/839 - (26%)

  Fly    63 ILDHNDEFVLVGAKDVIYNV-SLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYALR 125
            :|..:.:.:.:||::.::.| :||..::...:.|..::..:..||.||| .:.:|.||:||....
Human    54 LLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPL 118

  Fly   126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAF 190
            ....:.:||||:::|.|.|.              :..:.:: :.::.:.:|.||:.|||:.|...
Human   119 SATSLYVCGTNAFQPACDHL--------------NLTSFKF-LGKNEDGKGRCPFDPAHSYTSVM 168

  Fly   191 ADGHLYSATVADFSGGDPLIYREN----LRTEQYDLKQLNQPDFV-------------GAIERNG 238
            .||.|||.|..:|.|.:|:|.|.:    |||| |.:..||:|.||             |..:|
Human   169 VDGELYSGTSYNFLGSEPIISRNSSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDR-- 230

  Fly   239 YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEI 303
             |.|||.|:|:|.....:.:..|:|||||.|:||..:..|.|||||||||.||.| :....|:.:
Human   231 -VYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVL 293

  Fly   304 QAISPIVESGSK-SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GEF-KSQKDSQSH--WLPV 363
            :.:..:...|.| .:.||:||..:|.:..|||||:|:......|. |:: :|....|||  |:..
Human   294 RDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRY 358

  Fly   364 EREQVPKPRPGQCVE---------DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRL 419
             ...|||||||.|::         .|..|....:.|:|:||||:::|..:..||.|.|.::::
Human   359 -NGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY-- 420

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINI-LSTHPNSTVDRLKTVVISEMQVLPLGTPI 483
            |.|.| .:.::|.|..|||::..||.|.:.|.|:: .:.|           :|.|.|:.....|:
Human   421 TQIVV-DRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH-----------IIEETQLFQDFEPV 473

  Fly   484 RELVISTSKNSLVVV--SDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHEC--------- 537
            :.|::|:.|.:..|.  |:..:|..||..|.....|..|:..:||.|||...|..|
Human   474 QTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESP 538

  Fly   538 ----------------------------KNLATSQHKFGTKTYLQSL-----NSTKKAAA----- 564
                                        |:..|::.|...|:.|..:     |...||.:
Human   539 SRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGL 603

  Fly   565 -----LLCPHIPRDAPG-------------------AETVSFVTMAPPP----------TEEQKL 595
                 ||..::.....|                   |:.|..|.:.|.|          ||..::
Human   604 MGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRI 668

  Fly   596 LYS-NVGSSQGNQ---PSLEQQPTGGDDFGLNKITL--------TSMDPDDIMPNLNDPQKSTAS 648
            ... .|.|:||:.   |:::...:|.       |||        ||.:|..::..:  ||..:..
Human   669 ATKVLVASTQGSSPPTPAVQATSSGA-------ITLPPKPAPTGTSCEPKIVINTV--PQLHSEK 724

  Fly   649 VDEIKYASTPSFMLLTTIVFFTFLVGGIAGIC--------------CVKAKSRLMEAQ------- 692
            ...:|  |:.:.:|::..:||..|.     :|              |:|.:|.|:..:
Human   725 TMYLK--SSDNRLLMSLFLFFFVLF-----LCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDF 782

  Fly   693 --MDESHRNHFGKPMQFKHQN---------TGKDINLLMGSNAYTTTQKTPNLDLEKDR 740
              .::|.:....:|..|..||         ||           |.|.|.|....:..||
Human   783 CDREQSLKETLVEPGSFSQQNGEHPKPALDTG-----------YETEQDTITSKVPTDR 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_611244.1	Sema_1A	55..511	CDD:200498	151/483 (31%)
		PSI	510..>537	CDD:214655	9/26 (35%)
SEMA4D	NP_006369.3	Sema_4D	31..501	CDD:200520	150/481 (31%)
		PSI	503..554	CDD:396154	10/50 (20%)
		Ig_Sema4D_like	559..645	CDD:409457	13/85 (15%)
		Ig strand A	559..565	CDD:409457	0/5 (0%)
		Ig strand B	569..577	CDD:409457	2/7 (29%)
		Ig strand C	583..589	CDD:409457	0/5 (0%)
		Ig strand C'	591..594	CDD:409457	1/2 (50%)
		Ig strand D	600..604	CDD:409457	0/3 (0%)
		Ig strand E	607..614	CDD:409457	2/6 (33%)
		Ig strand F	620..629	CDD:409457	1/8 (13%)
		Ig strand G	633..645	CDD:409457	2/11 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..837		12/48 (25%)