DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA4F

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_004254.2	Gene:	SEMA4F / 10505	HGNCID:	10734	Length:	770	Species:	Homo sapiens

Alignment Length:	810	Identity:	214/810 - (26%)
Similarity:	343/810 - (42%)	Gaps:	162/810 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKSRPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQ---TKQDKVLAHFIGNSTDYFKI 63
            :::.||.......:..|::||..|||  .|:|.:|...|...   ::.|..|..|....|..:.:
Human     5 AARPRPGPGQPTASPFPLLLLAVLSG--PVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSV 67

  Fly    64 L--DHNDEFVLVGAKDVIYNVSL--NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYAL 124
            |  |.....:.|||:|.|:.:||  :| :...|::|...:|.|:.|..|||.|.:|||::::.|:
Human    68 LLVDPASHTLYVGARDTIFALSLPFSG-ERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAI 131

  Fly   125 RPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYA 189
            .....:|.|||.::.|:|   ..::||..:            :|.|....:|.||:.||..|...
Human   132 ANASHLLTCGTFAFDPKC---GVIDVSRFQ------------QVERLESGRGKCPFEPAQRSAAV 181

  Fly   190 FADGHLYSATVADFSGGDPLIYRENLRTEQYDLKQ-----LNQPDFVGAI----------ERNGY 239
            .|.|.||:|||.::.|.:|:|.|...|.|.:....     ||.|.||.|:          :.:..
Human   182 MAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDE 246

  Fly   240 VLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVP--GEFPFYFDE 302
            :.|||.|.|....::.:....||||||..|.||..:..:.||:||||.|.|..|  |.......:
Human   247 IYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQD 311

  Fly   303 IQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQ 367
            :..:.|.:.:|: .:.|.:|::.......||||||...||....:|.|:..|...:..|||....
Human   312 VAVLRPELGAGT-PIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDND 375

  Fly   368 VPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIA 423
            ||:||||:|:.:         |.:|....:.||::||||:..|....|.|||...:..:  ..:.
Human   376 VPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY--LRVV 438

  Fly   424 VHPQVKSLSGAYYDVIYSGTDDGKVTKFINI---LSTHPNSTVDRLKTVVISEMQVLPLGTPIRE 485
            .| :|.||||..|||:|.||:||.:.:.:.|   ||             |:.::.:.|...|:..
Human   439 AH-RVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLS-------------VLEDLALFPEPQPVEN 489

  Fly   486 LVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTK 550
            :.:..|  .|:|.|...:..|...:|..:..|..|:..|||:|||..:..||...| .:|    :
Human   490 MKLYHS--WLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHA-GEH----R 547

  Fly   551 TYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPT 615
            ..:|.:.|...::  |||..|.:.|      .|...|..|....:|..:..|:..:  .:..||:
Human   548 GLVQDIESADVSS--LCPKEPGERP------VVFEVPVATAAHVVLPCSPSSAWAS--CVWHQPS 602

  Fly   616 GGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAGIC 680
            |          :|::.|               ..|.::...||..|            |..|..|
Human   603 G----------VTALTP---------------RRDGLEVVVTPGAM------------GAYACEC 630

  Fly   681 -------CVKAKSRLMEAQMDESHRNH----------------------FGKPMQFKHQ------ 710
                   .|.|.|.:..:|.|...|.|                      .|:..|.:.|
Human   631 QEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLAR 695

  Fly   711 -NTGKDINL-LMGSNAYTTTQKTPNLDLEK 738
             ..|.|:.. ..|:.:|:....:|:.:.|:
Human   696 DKVGLDLGAPPSGTTSYSQDPPSPSPEDER 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	146/488 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
SEMA4F	NP_004254.2	Sema_4F	52..511	CDD:200522	148/493 (30%)
		PSI	512..563	CDD:279745	16/57 (28%)
		Ig_Sema4B_like	570..649	CDD:143280	21/123 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..725		5/28 (18%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q9Z123	768..770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910