DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and SEMA6B

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_011525941.1	Gene:	SEMA6B / 10501	HGNCID:	10739	Length:	894	Species:	Homo sapiens

Alignment Length:	727	Identity:	213/727 - (29%)
Similarity:	326/727 - (44%)	Gaps:	152/727 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSRPSSAAMLVNAIPMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAH---FIGNSTDYFKILD 65
            ::.|...|:|      :||:.|.|   ..|..|:..|.|.......|.|   |:|:........:
Human     5 RASPPRPALL------LLLLLLGG---AHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPAE 60

  Fly    66 HNDEF-----------VLVGAKDVIYNVSL-----NGLKEIARLEWHSTDADRELCALKGKHEWD 114
            ..|:.           :.:|.:|.:|.|.|     ..|:...:|.|.|..:|..:|.:|||.|.:
Human    61 GADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGE 125

  Fly   115 CHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCP 179
            |.|:::|..||....:.:||:|::.|.|.:|:...:.               .|..::.....||
Human   126 CRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQ---------------PVGDNISGMARCP 175

  Fly   180 YSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGY 239
            |.|.|.:...|:||.|::|||.||...|.:|||.     .|||.::|.|...:|.||.|:|...:
Human   176 YDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSH 240

  Fly   240 VLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEI 303
            |.|||||::||.....|.|.||||||||||.|| |....|.|||||||||||||||:..|||:.:
Human   241 VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVL 305

  Fly   304 QAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQV 368
            ||::.:|..|.:.::.|||:|..|:|||||||||::..:.|.|:|.|:.||..:|.|.||..:||
Human   306 QAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQV 370

  Fly   369 PKPRPGQCV------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQ 427
            |:||||.|.      ..|..|....:||:|.||||:||||::...|.:.:..:.|:||.:||  .
Human   371 PRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAV--D 433

  Fly   428 VKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLK--TVVISEMQVL-----------PL 479
            |.:.......|::.|::.|.|.||:    ..||::.....  :|.:.|.:..           ..
Human   434 VGAGPWGNQTVVFLGSEAGTVLKFL----VRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGET 494

  Fly   480 GTPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCL-------GCLSLQDPICAWDLQTHEC 537
            |..:..|.:..:...|:......:|.||:..|.....|:       .|:..|||.|.|
Human   495 GQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKSLVCSRNCIGSQDPYCGW------- 552

  Fly   538 KNLATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGS 602
                                                ||..   |.:.::|
Human   553 ------------------------------------APDG---SCIFLSP--------------- 563

  Fly   603 SQGNQPSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIV 667
              |.:.:.||..:|....||...|      ..:..:|::.:....||:.:..:|..:|::...:.
Human   564 --GTRAAFEQDVSGASTSGLGDCT------GLLRASLSEDRAGLVSVNLLVTSSVAAFVVGAVVS 620

  Fly   668 FFTFLVGGIAGI 679
            .|:  ||...|:
Human   621 GFS--VGWFVGL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	171/496 (34%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/33 (24%)
SEMA6B	XP_011525941.1	Sema_6B	57..524	CDD:200528	170/487 (35%)
SEMA6B	XP_011525941.1	PSI	525..>560	CDD:279745	11/80 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860