DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and SEMA6C

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001171532.1	Gene:	SEMA6C / 10500	HGNCID:	10740	Length:	962	Species:	Homo sapiens

Alignment Length:	792	Identity:	241/792 - (30%)
Similarity:	343/792 - (43%)	Gaps:	196/792 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IPMILLITLSGLTIVAGWMP-DVKP----DLQTK---------QDKVLAHFIGNSTDYFKILDHN 67
            :|::||:.|..|.......| |..|    |||..         :|..:|..:|  .|:.:.|..|
Human     8 MPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELG--LDFQRFLTLN 70

  Fly    68 DEFVLVGAKDVIYNVSL------NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
             ..:||.|:|.:::..|      .||.....|.|.|.|.  |.||::||...:|:||:||.....
Human    71 -RTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDV--ENCAVRGKLTDECYNYIRVLVPWD 132

  Fly   127 NGEVLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYA 189
            :..:|.|||||:.|.||.|  |.::...||                 :..|..||:....::...
Human   133 SQTLLACGTNSFSPVCRSYGITSLQQEGEE-----------------LSGQARCPFDATQSNVAI 180

  Fly   190 FADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSM 249
            ||:|.|||||.|||...|.::||.     .||:.:||.|.|.:|.||.|:|...:|.|||||:|:
Human   181 FAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSV 245

  Fly   250 EVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESG 313
            |....|:..:||||||||.|.|| |.:..:.||||||.||||||||:..||||.:||::..|...
Human   246 EDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGPVNLH 310

  Fly   314 SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV- 377
            .:|.::.||||..|:|||||||||.:|:|...|:|:||.|:.....|.||..::||.||||.|.
Human   311 GRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAG 375

  Fly   378 -------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQ--VKSLSG 433
                   ..||.|....:.|||.|||::.|||.|..:||||       ||:.|:..|  |..::|
Human   376 VGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLT-------LTSRALLTQVAVDGMAG 433

  Fly   434 AYYD--VIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIR------------ 484
            .:.:  |::.|::||.|.|.:.     |.......:.:::.|:...   :|.|
Human   434 PHSNITVMFLGSNDGTVLKVLT-----PGGRSGGPEPILLEEIDAY---SPARCSGKRTAQTARR 490

  Fly   485 --ELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHK 546
              .|.:.|..:.|.|...|.:|.:||..|:....| ..||:.|||.|.|    |..:.....:..
Human   491 IIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGW----HSSRGCVDIRGS 551

  Fly   547 FGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSN-----VGSSQGN 606
            .||..                     |..|              .::.:.:.:     .||..|.
Human   552 GGTDV---------------------DQAG--------------NQESMEHGDCQDGATGSQSGP 581

  Fly   607 QPSLEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVD------EIKYA----STPSFM 661
            ..|....|..|...|      |...|.|..|.   ||.||..|.      ::..|    |.|..:
Human   582 GDSAYVLPGPGPSPG------TPSPPSDAHPR---PQSSTLGVHTRGVRRDLPPASASRSVPIPL 637

  Fly   662 LLTTIVFFTFLVGGIAGI----CCVKAKSRLMEAQMDESHRNHFGKPMQFKHQNTGKDINLLMGS 722
            ||.::.....|...::|:    .|.:|                        |:..||||
Human   638 LLASVAAAFALGASVSGLLVSCACRRA------------------------HRRRGKDI------ 672

  Fly   723 NAYTTTQKTPNL 734
                   :||.|
Human   673 -------ETPGL 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	181/495 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)
SEMA6C	NP_001171532.1	Sema	53..517	CDD:301699	181/500 (36%)
SEMA6C	NP_001171532.1	PSI	518..570	CDD:279745	14/90 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820