DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and SEMA3A

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_006071.1	Gene:	SEMA3A / 10371	HGNCID:	10723	Length:	771	Species:	Homo sapiens

Alignment Length:	692	Identity:	198/692 - (28%)
Similarity:	305/692 - (44%)	Gaps:	130/692 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IGNSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEW-DCH 116
            :.||:.|.. :||.....:.|||||.|::..|..:|:..::.|..:...|:.|...||... :|.
Human    51 LANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECA 115

  Fly   117 NYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYS 181
            |:::|........:..|||.::.|.|.:.        |.|.....:..:.|.|.....:|..||.
Human   116 NFIKVLKAYNQTHLYACGTGAFHPICTYI--------EIGHHPEDNIFKLENSHFENGRGKSPYD 172

  Fly   182 PAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGA-------I 234
            |...:.....||.|||.|.|||.|.|..|:|     ..:||||:|.:.||.|.|:.|       .
Human   173 PKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDN 237

  Fly   235 ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FP 297
            ..:..|.|||||.:::..:.|||.::|:.::||||.||..|....||:||||||.|||||.  ..
Human   238 PEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGID 302

  Fly   298 FYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWL 361
            .:|||:|.:..:.....|: ::|.|||||.|...|||||.:::.|:...|.|.:..:......|:
Human   303 THFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWV 367

  Fly   362 PVEREQVPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRL 419
            |.: .:||.||||.|       .:.::.|....:.|.::||.|...|..::.||::.|.:::::.
Human   368 PYQ-GRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQF 431

  Fly   420 TAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIR 484
            |.|.| .:|.:..| .|||::.|||.|.|.|.::|    |..|...|:.|::.||.|....|.|.
Human   432 TQIVV-DRVDAEDG-QYDVMFIGTDVGTVLKVVSI----PKETWYDLEEVLLEEMTVFREPTAIS 490

  Fly   485 ELVISTSKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQ--------------- 533
            .:.:||.:..|.:.|...:..:|||.|. :...|..|...:||.||||..
Human   491 AMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRR 555

  Fly   534 ---------THECKNLATSQHK---------FG---TKTYL---------------QSLNSTKKA 562
                     || |.:|....|.         :|   :.|:|               |..|..:|.
Human   556 QDIRNGDPLTH-CSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKE 619

  Fly   563 AALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTG---------GD 618
            ...:..||.|                 |::..||           .||:|:.:|         |.
Human   620 EIRVDDHIIR-----------------TDQGLLL-----------RSLQQKDSGNYLCHAVEHGF 656

  Fly   619 DFGLNKITLTSMDPDDIMPNLN-DPQKSTASVDEIKYASTPS 659
            ...|.|:||..:|.:.:...|: |.....:...|:..:.|||
Human   657 IQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	156/479 (33%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	11/51 (22%)
SEMA3A	NP_006071.1	Sema_3A	26..518	CDD:200510	156/481 (32%)
		PSI	516..>552	CDD:214655	9/35 (26%)
		Ig_Sema3	579..670	CDD:409455	21/118 (18%)
		Ig strand B	593..597	CDD:409455	2/3 (67%)
		Ig strand C	605..609	CDD:409455	0/3 (0%)
		Ig strand E	632..636	CDD:409455	0/3 (0%)
		Ig strand F	646..651	CDD:409455	0/4 (0%)
		Ig strand G	663..666	CDD:409455	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910