DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema4gb

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_003199679.2	Gene:	sema4gb / 100534852	ZFINID:	ZDB-GENE-111117-1	Length:	881	Species:	Danio rerio

Alignment Length:	652	Identity:	193/652 - (29%)
Similarity:	303/652 - (46%)	Gaps:	109/652 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MILLITLSGLTIVAGWMP-------DVKPDLQTKQDKVLA--HFIGNSTDYFKILDHNDEFVL-V 73
            |:.||.:..|..|....|       ||.|....:.:.:|.  ||.|.:.:|..:|..:...|| |
Zfish     6 MLNLILVGYLIPVIWCFPFGPVLDMDVTPRTTVRVNGLLGCNHFQGAALNYSSLLLEDGPGVLYV 70

  Fly    74 GAKDVIYNV---SLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCG 134
            ||::.||.:   :::.......|||.::...:..|..||| ::.:|:|::|......:..:..||
Zfish    71 GAREAIYKLDTANISDTNNSLTLEWAASADQKRQCLSKGKNNQTECYNHVRFLDRYNDTHLYTCG 135

  Fly   135 TNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSAT 199
            |::::|||.:   ::|:             |:...|..|.:..|||.|....|....||.:|||:
Zfish   136 THAFRPRCAY---IDVA-------------RFTFVRFEEGKEKCPYDPTKGYTGFIIDGEMYSAS 184

  Fly   200 ------VADFSGGDPLIYRENLRTEQYDLKQLNQPDFVG----------AIERNGYVLFFFRELS 248
                  :||.....|.   .|||.:....:.|.:.||||          :|..:..:.|||.|.:
Zfish   185 QYEFRNIADIRRNFPF---PNLRIDDSPTRWLLESDFVGSALLRESINSSIGDDDKLYFFFTERN 246

  Fly   249 MEVMNFG-KAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312
            .|...:. :...:|||||||.|.||..:..:.|||||||||.|::| ::...|:.::::  .|..
Zfish   247 TEPTAYSIQTKVARVARVCKGDIGGQRTLQRKWTSFLKARLVCAIP-DYELQFNVLRSV--FVVE 308

  Fly   313 GSK---SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE---QVPKP 371
            ||.   |:.|.:|......:..||||.:::.||..||:|.|...:||:  |    ||   :||.|
Zfish   309 GSNVHDSVFYGIFGLEWRNVKMSAVCRYSLKDIQTAFNGPFMELQDSK--W----REYTGKVPDP 367

  Fly   372 RPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQ 427
            |||.|:.|         ||.|....:||::.||||...:..|.|||||.:....:  |.|.|. |
Zfish   368 RPGSCITDEHRGKLINSSRDLPDNTLNFVRRHPLMSTQIQPVEGRPLLLQKAADY--TKIIVQ-Q 429

  Fly   428 VKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSK 492
            |:.|.|..||:::.|||:|.:.:.:.|        :||:.  :|.|:|:.....||..:|||..:
Zfish   430 VEGLDGRTYDMLFIGTDEGWLQRAVKI--------IDRVH--IIEELQLFQEKQPIINMVISQKQ 484

  Fly   493 NSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLN 557
            ||:.|.....||.|||..|.....|..|:..:||:|.||  ...|..:|:..::   .:.:|.:.
Zfish   485 NSIYVSGASGLVQVPLSSCERYTSCYDCVFARDPLCGWD--GRMCAEIASYANR---SSLVQDIQ 544

  Fly   558 STKKAAALLCPHIPRDAPGAETVSFV------TMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTG 616
            ..::.    |.:|..|       .||      .||......|..:.||:.:.|....|.|.:..|
Zfish   545 MGRRG----CSNITSD-------GFVMHRTRAVMAGDDVLLQCEIRSNLATPQWTLNSQELKGYG 598

  Fly   617 GD 618
            .|
Zfish   599 VD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	155/492 (32%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/26 (31%)
sema4gb	XP_003199679.2	Sema_4G	47..501	CDD:200523	156/494 (32%)
		PSI	502..>541	CDD:279745	10/43 (23%)
		Ig	561..646	CDD:299845	10/40 (25%)
		IG_like	566..643	CDD:214653	10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910