DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema3a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_002935301.2	Gene:	sema3a / 100494110	XenbaseID:	XB-GENE-966369	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	210/725 - (28%)
Similarity:	332/725 - (45%)	Gaps:	104/725 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEW-DCHNY 118
            ||:.|.. :||.....:.|||||.|::.:|..:||..::.|..|:..|:.|...||... :|.|:
Frog    53 NSSSYHTFVLDEERGRLYVGAKDHIFSFNLANVKEFQKILWPVTNIRRDECKWAGKDIMKECANF 117

  Fly   119 LRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPA 183
            ::|..:..:..:..|||.::.|.|   |.::|.:...    ..:..:.|.|.....:|..||.|.
Frog   118 IKVLKVYNHTHLYACGTGAFHPVC---TYIDVGNYPE----QDNIFKLEDSFFENGRGKSPYDPK 175

  Fly   184 HNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLNQPDFVGAI-------ER 236
            ..:.....||.|||.|.|||.|.|..|:|     ..:||||:|.:.||.|.|:||.       ..
Frog   176 LLTASILIDGELYSGTAADFMGRDFAIFRTLGNHHPIRTEQHDSRWLNDPRFIGAYLVPESDNPE 240

  Fly   237 NGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGE--FPFY 299
            :..|.|||||.:::..:.|||.::|:.::||||.||..|....||:||||||.|||||.  ...:
Frog   241 DDKVYFFFRENAIDGEHTGKATHARIGQLCKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTH 305

  Fly   300 FDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPV 363
            |||:|.:..:.....|: ::|||||||.|...|||||.:::.||...|.|.:..:......|:|.
Frog   306 FDELQDVFLMNSKDPKNPVVYAVFTTSSNIFKGSAVCMYSLADIRRVFLGPYAHRDGPNYQWVPF 370

  Fly   364 EREQVPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTA 421
            : .:||.||||.|       .:.::.|....:.|.::||.|...|..::.||::.|..:.::.|.
Frog   371 Q-GRVPYPRPGTCPSKTFGGFDSTKDLPDEVIMFARSHPAMYNPVFPINNRPIIIKTEVDYQFTQ 434

  Fly   422 IAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIREL 486
            |.| .:|::..| .|||::.|||.|.|.|.:::    |..|...|:.|::.||.|....|.|..:
Frog   435 IVV-DRVEAEDG-QYDVMFIGTDMGTVLKVVSV----PKETWHDLEEVLLEEMTVFREPTAISAM 493

  Fly   487 VISTSKNSLVVVSDGSLVSVPLHHCS-HIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTK 550
            .|||.:..|.:.|...:..:|||.|. :...|..|...:||.||||  ...|.....:..:   :
Frog   494 EISTKQQQLYIGSSVGVSQLPLHRCDVYGKACAECCLARDPYCAWD--GSSCSRYFPTAKR---R 553

  Fly   551 TYLQSLNSTKKAAALLCPHIP-RDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQP 614
            |..|.:.:......  |..:. :|.|..:::           |:|::|....||...:.|.:.|
Frog   554 TRRQDIRNGDPLTH--CSDLQHQDDPHRQSL-----------EEKIIYGVENSSTFLECSPKSQ- 604

  Fly   615 TGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTI------VFFTFLV 673
                    ..|........      |:.:|....|||.| ..|...:||.|:      :::...|
Frog   605 --------RAIVFWQFQKQ------NEEKKEEIKVDERK-IKTEHGLLLRTLKKRDSGIYYCSAV 654

  Fly   674 GGIAGICCVKAKSRLMEAQ-MDE-SHRNHFGKPMQFKHQNTGKDINLLMGSNAYTTTQKT----- 731
            ........:|....:::.: :|| .|:...|.  ..||:..         ||:.:.|||.
Frog   655 EHGFMQTLLKVTLEIIDTEHLDELLHKEDEGD--SHKHKEP---------SNSMSPTQKIWYRDF 708

  Fly   732 ------PNLD 735
                  |||:
Frog   709 MQLINHPNLN 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	161/478 (34%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/27 (33%)
sema3a	XP_002935301.2	Sema_3A	26..519	CDD:200510	161/479 (34%)
		PSI	517..>553	CDD:214655	10/40 (25%)
		Ig_Semaphorin_classIII	582..672	CDD:143279	20/116 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100