DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1b and sema5b

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_031748739.1	Gene:	sema5b / 100493363	XenbaseID:	XB-GENE-959729	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	200/540 - (37%)
Similarity:	286/540 - (52%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LAHFIGNST-----DYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALK 108
            |..::.|.|     |:.:: ||.|...::|||::.::.:||:.:..|...||.|.:..:..|..|
Frog    61 LKPWLSNFTFSDVRDFSQLALDLNRNQLIVGARNYLFRLSLHNVSLIQAAEWSSDEDTQRSCQSK 125

  Fly   109 GKHEWDCHNYLRVYALRPNGE-VLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDV 172
            ||.|.:|.||:||  |..:|: |..||||::.|.|        :|.:.|:..       :|...:
Frog   126 GKTEDECQNYVRV--LIVSGKRVFTCGTNAFSPVC--------TSRQVGNLS-------KVIEKI 173

  Fly   173 EAQGLCPYSPAHNSTYAFAD-GHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFV 231
            .....|||.|.||||..... |.||:|||.||||.||:|||.     .|||.||:.|.||:|:||
Frog   174 NGVARCPYDPRHNSTAVMTTRGELYAATVIDFSGRDPVIYRSLGSVPPLRTAQYNSKWLNEPNFV 238

  Fly   232 GAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF 296
            .|.:...:..|||||.::| .:.||.||||||||||||.||.:....:||:|:|||||||.|||.
Frog   239 AAYDIGIFTYFFFRENAVE-HDCGKTVYSRVARVCKNDYGGRFLLEDTWTTFMKARLNCSRPGEI 302

  Fly   297 PFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWL 361
            |||::|:|:...:.|   :.|||.||||:||:|..|||||||:..|..||:|.|:.|::.:|.||
Frog   303 PFYYNELQSTFLLPE---QDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWL 364

  Fly   362 PVEREQVPKPRPGQCVEDS--RTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAV 424
            |. ...:|..:.|...:||  ..||..::...:...||.:.|..|...||:|:.::  |.:.:.|
Frog   365 PT-INPIPNFQCGILNDDSPNENLTERSLQDAQRLFLMNDVVQPVSVEPLVTQDSV--RFSKLVV 426

  Fly   425 HPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDR-LKTVVISEMQVLPLG--TPIREL 486
              .:.......|.|:|.||:.|.:.|.:        ||.:| |::..:.||.:||:|  .|||.|
Frog   427 --DIVQGKDTLYHVMYIGTEHGTILKAL--------STANRSLRSCYLEEMHILPIGQQEPIRSL 481

  Fly   487 VISTSKNSLVVVSDGSLVSVPLHHCSHI---VDCLGCLSLQDPICAWDLQTHECKNLATSQHKFG 548
            .|..|..||.|..:..::.|||..||..   .|.||.   :||.|.||.:...|.. |...:..|
Frog   482 QILHSNRSLFVGLNNGVLKVPLERCSIYRTEGDRLGA---RDPYCGWDSKKKRCTPXAYPHYITG 543

  Fly   549 TKTYLQSLNSTKKAAALLCP 568
            .:.            .|.||
Frog   544 PRN------------TLSCP 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	183/473 (39%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/29 (34%)
sema5b	XP_031748739.1	Sema_5B	68..504	CDD:200525	181/469 (39%)
		PSI	505..>533	CDD:214655	10/30 (33%)
		TSP1	613..674	CDD:214559
		TSP1	679..725	CDD:214559
		TSP1	810..862	CDD:214559
		TSP1	867..919	CDD:214559
		TSP1	922..963	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910