DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema6a

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_017946194.2	Gene:	sema6a / 100493034	XenbaseID:	XB-GENE-980417	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	832	Identity:	265/832 - (31%)
Similarity:	373/832 - (44%)	Gaps:	176/832 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGWMPDVKP-----DLQTKQDKVLAHFIG-----NSTDYFKILDHNDEFVL-----VGAKDVIYN 81
            ||:..|.:|     ...|||..|   |:|     |||...| :|.....::     :.|:|.||.
Frog    18 AGFPEDSEPISISHGNYTKQYPV---FVGHKPGRNSTQRHK-MDIQQIVIMNRTLYIAARDHIYT 78

  Fly    82 VSL--NGLKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKPR 141
            |.|  :..:||   .:|.|.|..:|.:.|.:||||:.:|||:::|...|....:.:||||::.|.
Frog    79 VDLETSYTEEIFFSKKLTWKSKQSDVDTCRMKGKHKDECHNFIKVLLKRDEDTLFVCGTNAFNPS 143

  Fly   142 CRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFS 204
            ||:|  ..:|...||                 :.....|||...|.:...||||.||||||.||.
Frog   144 CRYYKMDTLEFLDEE-----------------ISGMARCPYDAKHANVALFADGKLYSATVTDFL 191

  Fly   205 GGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVAR 264
            ..|.:|||.     .|||.:||.|.|.:|.||.|::....:.||:||:::|..:.||.|:.|||:
Frog   192 AIDAVIYRSLGDGPTLRTVKYDSKWLKEPYFVHAVDYGDLIYFFYREIAVEYNSMGKVVFPRVAQ 256

  Fly   265 VCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNA 328
            |||||.||... ..|.|||||||||||||||:..|||:.:||::.::....:.::.|.|:|..|:
Frog   257 VCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHINGRDVVLATFSTPYNS 321

  Fly   329 IPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQC--------VEDSRTLTS 385
            ||||||||:::.||.:.|.|.||.||...|.|.||..|:|||||||.|        :..|..|..
Frog   322 IPGSAVCAYDMADIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSATVERITKSNELPD 386

  Fly   386 IAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY--YDVIYSGTDDGKV 448
            ..:||||.||||:||||:|..|||..:..:.:|||.||    |.:.:|.|  :.|::.|::.|.|
Frog   387 DTLNFIKTHPLMDEAVPSVINRPLFLRTMVRYRLTKIA----VDTAAGPYQNHTVVFLGSERGIV 447

  Fly   449 TKFI------NILSTHPNSTVDRLKTVVISEMQVLP--------------LGTPIRELVISTSKN 493
            .||:      ..||          .::.:.||.|..              ||     :.:....|
Frog   448 LKFLARTGYSGFLS----------DSLFLEEMNVYNSEKCSFDGAEDKRILG-----MQLDKHNN 497

  Fly   494 SLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTKT-YLQSL 556
            :|.|.....:|||||..|.....| ..|::.:||.|.|..:...|..|.|     |||. :.|.:
Frog   498 ALYVAFSTCVVSVPLARCDRHTKCKKTCIASRDPYCVWLREGGTCSQLLT-----GTKVPFEQDV 557

  Fly   557 NSTKKAAALLCPHIPRDAPGAETVSFVTM-----APPPTEEQKLLYSNVGSSQGNQPSLEQQPTG 616
            .           |...|..|....|||.:     :|||  :|::.|..|........|...:
Frog   558 E-----------HGNTDGLGDCQNSFVALNEFATSPPP--DQEIYYHTVYDPSTTSYSRVHE--- 606

  Fly   617 GDDFGLNKITLTSMDPDDIMPNL--NDPQ--KSTASVDEIKYASTPSFM----------LLTTIV 667
            |.|.|      :.:|..||..:.  .||.  .|..:..:.|.....|::          ||...|
Frog   607 GYDRG------SMLDWKDIYDSSENTDPHVADSFHNHQDKKGVIRESYLKGHDQLVPVTLLAIAV 665

  Fly   668 FFTFLVG----GIAGICCVKAKSRLMEA------QMDESHRNH----------FGKPMQFKHQNT 712
            ...|::|    ||...|....:.|.::.      .:..|.|..          || ..|.|....
Frog   666 ILAFVMGAVFSGIIVYCICDHRRRDVDVVQRKDKDLSRSRRGSMASVTKLSGLFG-DSQSKESKP 729

  Fly   713 GKDINLLMGSNAYTTTQKTPNLDLEKDRSHECKNSTEHLE-KELPCKTSTLT 763
            ...:..||.:....|...|..: |.|...|       ||: ..||...||.|
Frog   730 EAILTPLMHNGKLATPSTTAKM-LIKAEQH-------HLDLAALPTPESTPT 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	189/508 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	7/27 (26%)
sema6a	XP_017946194.2	Sema	48..513	CDD:417757	187/501 (37%)
sema6a	XP_017946194.2	PSI	514..>544	CDD:396154	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm9356
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.000