DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema6c

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_002937315.2	Gene:	sema6c / 100486277	XenbaseID:	XB-GENE-989787	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	247/820 - (30%)
Similarity:	371/820 - (45%)	Gaps:	154/820 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PMILLITLSGLTIVAGWMPDVKPDLQTKQDKVLAHFIGNSTDYFKILDHNDEFVLVGAKDVIYNV 82
            |:.::.||:  |....|...:..|..|      ||.   ..|:.|:|..| :.:.|.|:|.:|.:
Frog    29 PIRIIETLT--TSSYPWFRGLASDDDT------AHL---GLDFQKMLKLN-QTLFVAARDHVYAI 81

  Fly    83 SLNGLKEI----ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCR 143
            .|...||.    ..:.|.:  .|.|.||::||...:|:||::|...:.:..::.|||||:.|.||
Frog    82 DLRRAKEAIIPDKYVTWKT--QDMENCAMRGKLRDECYNYIKVLVPKNDQTLVACGTNSFNPMCR 144

  Fly   144 HYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDP 208
            .|....:..|               ..:...|..||:.....:...||||:|||||:|||...|.
Frog   145 SYKIKTLEQE---------------GEEFNGQARCPFDAKQANVALFADGNLYSATMADFQASDA 194

  Fly   209 LIYRE------NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCK 267
            :|||.      .|||.:||.|.|.:|.|:.|:|...||.|||||:|||....||..:|||.||||
Frog   195 VIYRSLGEKSPVLRTVKYDSKWLREPHFIHAVEYGNYVYFFFREISMEYTTIGKVTFSRVGRVCK 259

  Fly   268 NDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPG 331
            ||.|| |....|.|||||||||||||||:..||||.:|::|.|:...::..:..||.|..|:|.|
Frog   260 NDMGGSPRVLEKYWTSFLKARLNCSVPGDSFFYFDVLQSVSDILTINNRPAVIGVFGTQANSITG 324

  Fly   332 SAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV--------EDSRTLTSIAV 388
            |.|||:.:|||...|:|:||.||.::|.|.|:..::||.||||.|.        :.|.......:
Frog   325 SGVCAYYMDDIEKVFNGKFKEQKTTESAWTPIPEDKVPTPRPGCCAGYGKAATYKTSNEFPDETL 389

  Fly   389 NFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAY--YDVIYSGTDDGKVTKF 451
            :|||::||::|||.::...|..||.....:||    |....:.:|.|  |.|::.|::||||.|.
Frog   390 SFIKSYPLLDEAVLSITETPWFTKTTSRFKLT----HLAADTSAGPYGNYTVLFLGSEDGKVLKV 450

  Fly   452 INILSTHPNSTVDRLKTVVISEMQVL-PLGTPIRE-------LVISTSKNSLVVVSDGSLVSVPL 508
            ::  .|..||||:   |:::.::.|. |....:::       |.:....::|.|.....::.|||
Frog   451 LS--GTTENSTVE---TLLLEDINVYNPAKCNVKKEDRRILGLQLDRENHALFVAFSSCIIRVPL 510

  Fly   509 HHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAALLCPHI-- 570
            ..|.....| ..||:.:||.|.| |::..|    .|.......::.|.:..:|....  |..:
Frog   511 SRCELYGTCRRSCLASRDPYCVW-LKSGAC----ASYRNDIRGSFEQDIEQSKNWGN--CQDVVT 568

  Fly   571 PRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNKI----TLTSMD 631
            ...:.|.|..|....|||..:   :..::| :|.|:...|...|.|....|..::    ||.:
Frog   569 SSGSVGNEGDSAYGKAPPSGD---IAIASV-ASLGHVTRLGYSPPGVTSDGYYQLSAWHTLKT-- 627

  Fly   632 PDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAG---ICC------------ 681
                       |.....|..::.:.:..|..|...||..|:||.|..   :.|
Frog   628 -----------QGVRQEVGSMESSKSVHFTFLIGCVFVAFVVGAIFSGLFVSCYCNHMFQKNKHV 681

  Fly   682 ----------------VKAKSRLMEAQMDESHRNHFGKPMQF-------KHQNT------GKDIN 717
                            :...:.|:|:|..|. |.....|..:       |.|.|      .||..
Frog   682 GRDPESSLQRPLSLRSLAKMNGLLESQSKEG-RMEPTSPKLYTTLLHGEKEQTTETTKGESKDHP 745

  Fly   718 LLMGSNAYTTTQKTPNLDLEK--------DRSHECKNSTE 749
            .|.|   ..|.:.||.|.::.        :|:..|.|:.|
Frog   746 ELSG---LPTPESTPELPMKNLKAFKNQWERNQNCNNAKE 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	177/484 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/27 (33%)
sema6c	XP_002937315.2	Sema_6E	50..511	CDD:200531	180/496 (36%)
sema6c	XP_002937315.2	PSI	512..>533	CDD:214655	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm9356
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010