DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1b and sema6d

DIOPT Version :9

Sequence 1:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001120152.1	Gene:	sema6d / 100145190	XenbaseID:	XB-GENE-967070	Length:	1084	Species:	Xenopus tropicalis

Alignment Length:	831	Identity:	252/831 - (30%)
Similarity:	373/831 - (44%)	Gaps:	204/831 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NSTDYFKILDHNDEFVLVGAKDVIYNVSLNGLKEI-----ARLEWHSTDADRELCALKGKHEWDC 115
            :|.|:..:|...|...:.| :|.:|.::||.:.:.     .||.|.|..|||:.||:||||:.:|
Frog    55 HSLDFQLMLKIRDTLYVAG-RDQVYAINLNEVPKTEVTPSRRLTWRSGQADRKNCAMKGKHKDEC 118

  Fly   116 HNYLRVYALRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPY 180
            |||::|:..|.:..|.:||||::.|.||:|              ..:...|: ..::.....||:
Frog   119 HNYIKVFVPRNDEMVFVCGTNAFNPMCRYY--------------RLNTFDYD-GEEISGLARCPF 168

  Fly   181 SPAHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYV 240
            .....:...||||.|||||:|||...|.:|||.     .|||.:||.|.|.:|.|:.|||...|:
Frog   169 DARQTNVALFADGKLYSATMADFQASDAVIYRSMGDGFALRTIKYDSKWLKEPHFLHAIEYGNYI 233

  Fly   241 LFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFYFDEIQ 304
            .|||||:::|..|.||||:|||||:||||.||... ..|.||||:||||||||||:..||||.:|
Frog   234 YFFFREIAVEHNNLGKAVHSRVARICKNDLGGSQRVLEKHWTSFVKARLNCSVPGDSFFYFDVLQ 298

  Fly   305 AISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVP 369
            :|:.|:|......:..||||.:|:|||||||||.:|||...|.|.||.||...|.|..|..::||
Frog   299 SITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFTMDDIEKVFRGRFKEQKTPDSVWTAVPEDRVP 363

  Fly   370 KPRPGQCV-----EDSRTLTSI---AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHP 426
            |||||.|.     |..|:.|..   .::|||:||||:.|:|::...|..||..:.:||||:|
Frog   364 KPRPGCCARHGYGEGYRSSTEFPDETLSFIKSHPLMDSAIPSIIEEPWFTKTRVRYRLTAVA--- 425

  Fly   427 QVKSLSGAY--YDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLG--------- 480
             |..|:|.|  |.|::.|::.|.|.|.  :..|:|.|..|   :|::.|:......
Frog   426 -VDHLAGPYLNYTVMFVGSEAGVVLKI--LAKTNPFSLND---SVLLEEIDAYNRAKCSGNSEED 484

  Fly   481 TPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAW-------------- 530
            ..:..|.:....::|.|...|.:|.:||..|.....| ..|:..:||.|.|
Frog   485 RKVISLQMDRDHHALFVAFSGCIVRLPLSRCERYGSCKKSCIGARDPYCGWLNHESCGRVKPGMF 549

  Fly   531 -----------DLQTHECKNL----ATSQHK-FGTKT---YLQSLNSTKKAAALLCPHI-----P 571
                       .:|..:|.::    .|..:| ||..|   .:.|.:.|..::.::.|.:     |
Frog   550 FGYEQDVEYGNTVQLGDCHDILPTATTPDYKIFGDPTSDIEVPSTSVTTTSSPVILPKVIGSWKP 614

  Fly   572 RDAPGAETVSFVTMAPPPTEE--------QKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNKITLT 628
            | ..|:.  .|:....|.|.|        ||.:...|.|...||
Frog   615 R-MTGSR--KFIYQDDPNTSEYIDPLTGVQKGVRWEVQSGDANQ--------------------- 655

  Fly   629 SMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGG-IAGIC--CVK----AKS 686
                   |.::|                     :|.|.|...|::|. |||:.  |.:    .|:
Frog   656 -------MVHMN---------------------VLITCVLAAFVLGAFIAGVIVYCYREMFVRKT 692

  Fly   687 RLMEAQMDESH------------RNHFGKPMQFKHQN-------------------TGKDINLLM 720
            |.:....:.:.            ...|..|::..||:                   .|:..:::|
Frog   693 RKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYHQSIDSPKHYTNILTSRKELPPNGETKSMMM 757

  Fly   721 GSN-------AYTTTQKTP-----NLDLEKDRSHECKNSTEHLEKELPCKT 759
            .|.       |..|.:.||     :|...|::..:..|:.....||.|.|:
Frog   758 DSQGQPPELAALPTPESTPVLHQKSLQPIKNQWEKTHNNLNISRKETPLKS 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	191/484 (39%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/52 (15%)
sema6d	NP_001120152.1	Sema_6D	49..513	CDD:200530	190/482 (39%)
		PSI	514..>543	CDD:396154	7/28 (25%)
		ARG80	<829..1080	CDD:227400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm9356
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010