Protein Alignment eIF3c and EIF3C

DIOPT Version :10

• Sequence 1: NP_611242.1
• Gene: eIF3c / 37005
• FlyBaseID: FBgn0034258
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_003743.1
• Gene: EIF3C / 8663
• HGNCID: 3279
• Length: 913
• Species: Homo sapiens
• Alignment Length: 939
• Identity: 479/939 - (51%)
• Similarity: 630/939 - (67%)
• Gaps: 67/939 - (7%)

  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59
            |||||..||:||||||   ||.:.   ..|:.| .....|:|||:.||||||.|:||:|.||::|
Human     1 MSRFFTTGSDSESESSLSGEELVTKPVGGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64

  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||||.||:|||::||:|||:||
Human    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYIRILADLEDYLNELWEDKEG 126

  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.:.||
Human   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGV 191

  Fly   190 -------KPTEAVPKAVKSAPAKAAPADDD--DSDDSIDWDSDS-ESETESSDDENQYQNMRERF 244
                   |.:||.....:....|....|:|  ||:|..|||:.| .|:::|.::|.:...:..||
Human   192 SAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRF 256

  Fly   245 LKR--TTEK-----EEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKG--HVVEKPKMFEKD 300
            ||:  ||::     |:|.:||.|.|...:..::.:..||:|.||||.|..|  .|.||||||.|.
Human   257 LKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKG 321

  Fly   301 AEIDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYN 365
            .||...:|:.||.||:.|||||.|||..||:||..|..|:.::|||..|.|||.||||:::||||
Human   322 TEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYN 386

  Fly   366 QKISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEY--ATSPFYVRGCPLAAVERL 428
            ..::..||.|.|...|:.:..:|.:|.||.:|.:.|::.||.|..  |..|..||||.|..|||:
Human   387 PNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERM 451

  Fly   429 DDEFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD- 492
            |:||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|||||.:|.|.|||||
Human   452 DEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDY 516

  Fly   493 ---------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDN 547
                     || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|..
Human   517 KAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSR 581

  Fly   548 WFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELL 612
            |:|||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.||||
Human   582 WYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELL 646

  Fly   613 AQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMIS 677
            .||||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.||||||||
Human   647 GQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMIS 711

  Fly   678 KTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVR 742
            |.|:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:||
Human   712 KQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVR 776

  Fly   743 EMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSET 807
            .||.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::|
Human   777 TMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQT 841

  Fly   808 VGMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGNW 872
            |.|||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.:
Human   842 VVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGYF 885

  Fly   873 LGQRRDRNNRNRNQRGHHKNNQDRQQQQQ 901
                ||:.:..|...|:.:....||||.|
Human   886 ----RDQKDGYRKNEGYMRRGGYRQQQSQ 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_611242.1	eIF-3c_N	24..671	CDD:428482	334/678 (49%)
		PINT	744..823	CDD:214509	54/78 (69%)
EIF3C	NP_003743.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..705	CDD:428482	334/679 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..301		40/143 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..542		3/19 (16%)
		PINT	778..866	CDD:214509	57/87 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	885..913		9/30 (30%)