DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3c and NIP1

DIOPT Version :9

Sequence 1:	NP_001286545.1	Gene:	eIF3c / 37005	FlyBaseID:	FBgn0034258	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_014040.1	Gene:	NIP1 / 855357	SGDID:	S000004926	Length:	812	Species:	Saccharomyces cerevisiae

Alignment Length:	899	Identity:	226/899 - (25%)
Similarity:	400/899 - (44%)	Gaps:	216/899 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FANGSESESES-------------------SEEEIQ---ATNFNKASAFQFSD---DEEEVKRVV 44
            |.|.||||||:                   ||...|   :..|.|:|.:..||   |||:.|:||
Yeast    48 FFNESESESEADVDSDDSDAKPYGPDWFKKSEFRKQGGGSNKFLKSSNYDSSDEESDEEDGKKVV 112

  Fly    45 RSTKEKRYENLTSIIKTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLA 109
            :|.|||..:.:..:...|...:...|.....:.|:.::|     |.|.::::|..||..:|:.:|
Yeast   113 KSAKEKLLDEMQDVYNKISQAENSDDWLTISNEFDLISR-----LLVRAQQQNWGTPNIFIKVVA 172

  Fly   110 ELEDFINEVWEDREGRKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVAL 174
            ::||.:|..  .:...||  |..:::..|.:|:|:|..::.||.:::||..|
Yeast   173 QVEDAVNNT--QQADLKN--KAVARAYNTTKQRVKKVSRENEDSMAKFRNDP------------- 220

  Fly   175 ESDGGDAGDDSDAGVKPTEAVPKAVKSAPAKAAPADDDDSDDSIDWDSDSESETESSDDENQYQN 239
                                               :..|.:.:.|.|..:...|.||...|. |.
Yeast   221 -----------------------------------ESFDKEPTADLDISANGFTISSSQGND-QA 249

  Fly   240 MRERFLKRTTEKEEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKGHVVEKPKMFEKDAEID 304
            ::|.|..|
Yeast   250 VQEDFFTR--------------------------------------------------------- 257

  Fly   305 VPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYNQKIS 369
                   |..|:.:||||..:::..|..|.||..::::    ....:..:..:|.:.:|.:..:|
Yeast   258 -------LQTIIDSRGKKTVNQQSLISTLEELLTVAEK----PYEFIMAYLTLIPSRFDASANLS 311

  Fly   370 -EPMKLEHW-------ALLLEVMQSMMKLLLAN--ADIIMSESVAEEHEEYATSPFYVRGCPLAA 424
             :|  ::.|       :.||.::...:.....|  ||.|  :.:.:|.:|.:.....:.|...:.
Yeast   312 YQP--IDQWKSSFNDISKLLSILDQTIDTYQVNEFADPI--DFIEDEPKEDSDGVKRILGSIFSF 372

  Fly   425 VERLDDEFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFE---RSGTNNERC--RIYLRKI 484
            ||||||||:|.|...||||:||:.||:||.::...|.....|||   :...:.||.  |.:::::
Yeast   373 VERLDDEFMKSLLNIDPHSSDYLIRLRDEQSIYNLILRTQLYFEATLKDEHDLERALTRPFVKRL 437

  Fly   485 EHLYYKFD--------------PEVLKKK---RGELPATTSTSVDVMDKL---CKFIYAKDDTDR 529
            :|:|||.:              |...|.|   :.:|     .|.|.:|.|   ...|.:|.:...
Yeast   438 DHIYYKSENLIKIMETAAWNIIPAQFKSKFTSKDQL-----DSADYVDNLIDGLSTILSKQNNIA 497

  Fly   530 IRTRAILAHIYHHAMHDNWFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKD 594
            ::.||||.:||:.|::.::..|:|::|.|.:|.||:..|.:.:||:||::..|||.||:...:::
Yeast   498 VQKRAILYNIYYTALNKDFQTAKDMLLTSQVQTNINQFDSSLQILFNRVVVQLGLSAFKLCLIEE 562

  Fly   595 AHHCLVDLMVTGKPKELLAQGLLPQRQHERSAEQEKIEKQRQ-MPFHMHINLELLECVYLVSAML 658
            .|..|.||:.:...:|:|.|..|.:.....|......|:.|| :|:|.||||:|::.|:|..::|
Yeast   563 CHQILNDLLSSSHLREILGQQSLHRISLNSSNNASADERARQCLPYHQHINLDLIDVVFLTCSLL 627

  Fly   659 LEIPYIAAHEFDARRRMI---SKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACAN 720
            :|||.:.|.....:.:.|   .|:..:.|...::.|..||||::|::|:.|||:|:.|||:....
Yeast   628 IEIPRMTAFYSGIKVKRIPYSPKSIRRSLEHYDKLSFQGPPETLRDYVLFAAKSMQKGNWRDSVK 692

  Fly   721 FIVNKKMNTKVWDLFYESDRVREMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVH 785
            ::    ...|.|.|....:.|...||:.::.|||:||.|::...|:|.|:..||::::||..||.
Yeast   693 YL----REIKSWALLPNMETVLNSLTERVQVESLKTYFFSFKRFYSSFSVAKLAELFDLPENKVV 753

  Fly   786 SIISKMIINEELMASLDDPSETVGMHRSEPSRLQALAMQFVDKVTNLVDVNEKV 839
            .::..:|...|:.|.|:| .:|:            ..::..|::|.|.:...|:
Yeast   754 EVLQSVIAELEIPAKLND-EKTI------------FVVEKGDEITKLEEAMVKL 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_001286545.1	eIF-3c_N	24..671	CDD:283193	167/685 (24%)
eIF3c	NP_001286545.1	PAM	744..823	CDD:214803	23/78 (29%)
NIP1	NP_014040.1	eIF-3c_N	92..640	CDD:283193	166/682 (24%)
NIP1	NP_014040.1	PINT	712..796	CDD:214509	27/96 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344186
Domainoid	1	1.000	153	1.000	Domainoid score	I916
eggNOG	1	0.900	-	-		E1_KOG1076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2781
Inparanoid	1	1.050	229	1.000	Inparanoid score	I734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54519
OrthoFinder	1	1.000	-	-		FOG0003671
OrthoInspector	1	1.000	-	-		oto99748
orthoMCL	1	0.900	-	-		OOG6_101999
Panther	1	1.100	-	-	LDO	PTHR13937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R378
SonicParanoid	1	1.000	-	-		X2545
TreeFam	1	0.960	-	-
	15	14.790