DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3c and EIF3CL

DIOPT Version :9

Sequence 1:	NP_001286545.1	Gene:	eIF3c / 37005	FlyBaseID:	FBgn0034258	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001093131.1	Gene:	EIF3CL / 728689	HGNCID:	26347	Length:	914	Species:	Homo sapiens

Alignment Length:	940	Identity:	481/940 - (51%)
Similarity:	633/940 - (67%)	Gaps:	68/940 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59
            |||||..||:||||||   ||.:.   ..|:.| .....|:|||:.||||||.|:||:|.||::|
Human     1 MSRFFTTGSDSESESSLSGEELVTKPVGGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64

  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||||.||:|||::||:|||:||
Human    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYIRILADLEDYLNELWEDKEG 126

  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.:.||
Human   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGV 191

  Fly   190 -------KPTEAVPKAVKSAPAKAAPADDD--DSDDSIDWDSDS-ESETESSDDENQYQNMRERF 244
                   |.:||.....:....|....|:|  ||:|..|||:.| .|:::|.::|.:...:..||
Human   192 SAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRF 256

  Fly   245 LKR--TTEKEEK-DDDKRKDKRKEQKTKIRKR-----AEDDEDGEWETVVKG--HVVEKPKMFEK 299
            ||:  ||::::| .:.||:||.|::..:..||     .||:|.||||.|..|  .|.||||||.|
Human   257 LKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEEDNEGGEWERVRGGVPLVKEKPKMFAK 321

  Fly   300 DAEIDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDY 364
            ..||...:|:.||.||:.|||||.|||..||:||..|..|:.::|||..|.|||.||||:::|||
Human   322 GTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDY 386

  Fly   365 NQKISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEY--ATSPFYVRGCPLAAVER 427
            |..::..||.|.|...|:.:..:|.:|.||.:|.:.|::.||.|..  |..|..||||.|..|||
Human   387 NPNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVER 451

  Fly   428 LDDEFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD 492
            :|:||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|||||.:|.|.|||||
Human   452 MDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFD 516

  Fly   493 ----------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHD 546
                      || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|.
Human   517 YKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHS 581

  Fly   547 NWFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKEL 611
            .|:|||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.|||
Human   582 RWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKEL 646

  Fly   612 LAQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMI 676
            |.||||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.|||||||
Human   647 LGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMI 711

  Fly   677 SKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRV 741
            ||.|:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:|
Human   712 SKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKV 776

  Fly   742 REMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSE 806
            |.||.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::
Human   777 RTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQ 841

  Fly   807 TVGMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGN 871
            ||.|||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.
Human   842 TVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGY 885

  Fly   872 WLGQRRDRNNRNRNQRGHHKNNQDRQQQQQ 901
            :    ||:.:..|...|:.:....||||.|
Human   886 F----RDQKDGYRKNEGYMRRGGYRQQQSQ 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_001286545.1	eIF-3c_N	24..671	CDD:283193	336/679 (49%)
eIF3c	NP_001286545.1	PAM	744..823	CDD:214803	54/78 (69%)
EIF3CL	NP_001093131.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..706	CDD:283193	336/680 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..302		42/144 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..543		3/19 (16%)
		PAM	779..867	CDD:214803	57/87 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..914		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148277
Domainoid	1	1.000	619	1.000	Domainoid score	I179
eggNOG	1	0.900	-	-		E1_KOG1076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	873	1.000	Inparanoid score	I417
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54519
OrthoDB	1	1.010	-	-		D120738at33208
OrthoFinder	1	1.000	-	-		FOG0003671
OrthoInspector	1	1.000	-	-		otm41498
orthoMCL	1	0.900	-	-		OOG6_101999
Panther	1	1.100	-	-	LDO	PTHR13937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R378
SonicParanoid	1	1.000	-	-		X2545
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800