Protein Alignment eIF3c and Eif3c

DIOPT Version :10

• Sequence 1: NP_611242.1
• Gene: eIF3c / 37005
• FlyBaseID: FBgn0034258
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_666312.1
• Gene: Eif3c / 56347
• MGIID: 1926966
• Length: 911
• Species: Mus musculus
• Alignment Length: 937
• Identity: 477/937 - (50%)
• Similarity: 634/937 - (67%)
• Gaps: 65/937 - (6%)

  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59
            |||||..||:||||||   ||.:.   :.|:.| .....|:|||:.||||||.|:||:|.||::|
Mouse     1 MSRFFTTGSDSESESSLSGEELVTKPVSGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64

  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||||.||:|||::||:|||:||
Mouse    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYIRILADLEDYLNELWEDKEG 126

  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.:.||
Mouse   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGV 191

  Fly   190 KPTEAVPKAVKSAPA-----KAAPADDDDSDDSID--WD-SDSESETESSDDENQYQNMRERFLK 246
            ..|..:.|..:|:..     |....||:||:||.|  || |.:.|:::|.::|.:...:..:|||
Mouse   192 GNTTFLKKKQESSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLK 256

  Fly   247 R--TTEK-----EEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKG--HVVEKPKMFEKDAE 302
            :  |||:     |:|.:||.|.|...:..::.:..||:|.||||.|..|  .|.||||||.|..|
Mouse   257 KAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTE 321

  Fly   303 IDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYNQK 367
            |...:|:.||.||:..||||.|||..||:||..|..|:.::|||..|.|||.||||:::||||..
Mouse   322 ITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPN 386

  Fly   368 ISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYAT--SPFYVRGCPLAAVERLDD 430
            ::..||.|.|.:.|:.:..:|..|:|:::|.:.|::.||.|....  .|..||||.|..|||:|:
Mouse   387 LATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDE 451

  Fly   431 EFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD--- 492
            ||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|:||||:|.|.|||||
Mouse   452 EFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKA 516

  Fly   493 -------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWF 549
                   || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|..|:
Mouse   517 HQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWY 581

  Fly   550 QARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLAQ 614
            |||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.||||.|
Mouse   582 QARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQ 646

  Fly   615 GLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKT 679
            |||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.|||||||||.
Mouse   647 GLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQ 711

  Fly   680 FYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREM 744
            |:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:||.|
Mouse   712 FHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTM 776

  Fly   745 LTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVG 809
            |.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::||.
Mouse   777 LVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVV 841

  Fly   810 MHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGNWLG 874
            |||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.:
Mouse   842 MHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGYF-- 883

  Fly   875 QRRDRNNRNRNQRGHHKNNQDRQQQQQ 901
              ||:.:..|...|:.:....||||.|
Mouse   884 --RDQKDGYRKNEGYMRRGGYRQQQSQ 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_611242.1	eIF-3c_N	24..671	CDD:428482	332/676 (49%)
		PINT	744..823	CDD:214509	54/78 (69%)
Eif3c	NP_666312.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..703	CDD:428482	332/677 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..299		41/141 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..540		3/19 (16%)
		PINT	776..864	CDD:214509	57/87 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..911		9/30 (30%)