DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3c and Eif3c

DIOPT Version :9

Sequence 1:	NP_001286545.1	Gene:	eIF3c / 37005	FlyBaseID:	FBgn0034258	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_666312.1	Gene:	Eif3c / 56347	MGIID:	1926966	Length:	911	Species:	Mus musculus

Alignment Length:	937	Identity:	477/937 - (50%)
Similarity:	634/937 - (67%)	Gaps:	65/937 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59
            |||||..||:||||||   ||.:.   :.|:.| .....|:|||:.||||||.|:||:|.||::|
Mouse     1 MSRFFTTGSDSESESSLSGEELVTKPVSGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64

  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||||.||:|||::||:|||:||
Mouse    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYIRILADLEDYLNELWEDKEG 126

  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.:.||
Mouse   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGV 191

  Fly   190 KPTEAVPKAVKSAPA-----KAAPADDDDSDDSID--WD-SDSESETESSDDENQYQNMRERFLK 246
            ..|..:.|..:|:..     |....||:||:||.|  || |.:.|:::|.::|.:...:..:|||
Mouse   192 GNTTFLKKKQESSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLK 256

  Fly   247 R--TTEK-----EEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKG--HVVEKPKMFEKDAE 302
            :  |||:     |:|.:||.|.|...:..::.:..||:|.||||.|..|  .|.||||||.|..|
Mouse   257 KAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTE 321

  Fly   303 IDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYNQK 367
            |...:|:.||.||:..||||.|||..||:||..|..|:.::|||..|.|||.||||:::||||..
Mouse   322 ITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPN 386

  Fly   368 ISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYAT--SPFYVRGCPLAAVERLDD 430
            ::..||.|.|.:.|:.:..:|..|:|:::|.:.|::.||.|....  .|..||||.|..|||:|:
Mouse   387 LATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDE 451

  Fly   431 EFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD--- 492
            ||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|:||||:|.|.|||||
Mouse   452 EFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKA 516

  Fly   493 -------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWF 549
                   || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|..|:
Mouse   517 HQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWY 581

  Fly   550 QARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLAQ 614
            |||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.||||.|
Mouse   582 QARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQ 646

  Fly   615 GLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKT 679
            |||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.|||||||||.
Mouse   647 GLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQ 711

  Fly   680 FYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREM 744
            |:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:||.|
Mouse   712 FHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTM 776

  Fly   745 LTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVG 809
            |.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::||.
Mouse   777 LVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVV 841

  Fly   810 MHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGNWLG 874
            |||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.:
Mouse   842 MHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGYF-- 883

  Fly   875 QRRDRNNRNRNQRGHHKNNQDRQQQQQ 901
              ||:.:..|...|:.:....||||.|
Mouse   884 --RDQKDGYRKNEGYMRRGGYRQQQSQ 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_001286545.1	eIF-3c_N	24..671	CDD:283193	332/676 (49%)
eIF3c	NP_001286545.1	PAM	744..823	CDD:214803	54/78 (69%)
Eif3c	NP_666312.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..703	CDD:283193	332/677 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..299		41/141 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..540		3/19 (16%)
		PAM	776..864	CDD:214803	57/87 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	883..911		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838365
Domainoid	1	1.000	619	1.000	Domainoid score	I181
eggNOG	1	0.900	-	-		E1_KOG1076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2781
Inparanoid	1	1.050	874	1.000	Inparanoid score	I407
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54519
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003671
OrthoInspector	1	1.000	-	-		oto93861
orthoMCL	1	0.900	-	-		OOG6_101999
Panther	1	1.100	-	-	LDO	PTHR13937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R378
SonicParanoid	1	1.000	-	-		X2545
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790