DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3c and eif3c

DIOPT Version :9

Sequence 1:	NP_001286545.1	Gene:	eIF3c / 37005	FlyBaseID:	FBgn0034258	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_005156056.1	Gene:	eif3c / 334234	ZFINID:	ZDB-GENE-030131-6166	Length:	943	Species:	Danio rerio

Alignment Length:	948	Identity:	494/948 - (52%)
Similarity:	655/948 - (69%)	Gaps:	60/948 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRFFANGSESESE--SSEEEI---QATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSIIK 60
            ||||||.||:||||  ||.:||   .|....:..|...|||||:.||||||.|:||:|.||::||
Zfish     1 MSRFFATGSDSESEESSSADEITPKAAGTTLRQQALLLSDDEEDTKRVVRSAKDKRFEELTNLIK 65

  Fly    61 TIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREGR 125
            ||||..||:||...|..||.|.||:.|:..::.||  |: |:||||.||:|||::|::|||:||:
Zfish    66 TIRNAIKIRDISKCLEEFEQLCRAFVKSKTIVDKE--GV-PKFYIRLLADLEDYLNQLWEDKEGK 127

  Fly   126 KNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV- 189
            |.::|||:|:|.|||||:|||.:|||.:::.::|.|:|.::.|:|...:.|...::.||.|..:
Zfish   128 KKMNKNNAKALSTLRQKIRKYNRDFETEIASYKENPEQSADEEEEKDDIGSGSSESDDDDDDDIT 192

  Fly   190 -------KPTEAVPKAVKSAPAKAAPADD----DDSDDSIDWDSDS-ESETESSDDENQYQNMRE 242
                   ||.|...||.:::......||:    ||.:||.||.||| .|::||.|::....::..
Zfish   193 AKSFMKKKPQEEEKKAPEASKFLKGAADEESESDDDEDSEDWASDSVGSDSESEDNDGTAASLAV 257

  Fly   243 RFLKRTT-EK---EEKDDDKRKDKRKEQKTKIRKRAEDD---EDGEWETVVKG--HVVEKPKMFE 298
            .|||:.. ||   .:|||.:|:.|:||   :|.:.||::   |:|.||.|..|  .|.||||||.
Zfish   258 VFLKKDVGEKASDRKKDDRRRRHKKKE---RIEEEAEEEGEAEEGGWEKVKGGVPLVKEKPKMFA 319

  Fly   299 KDAEIDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYD 363
            |..||:..:|:.||.||:.|||||.|||..||:||..|..|:.::|||..:.|||.||||:::||
Zfish   320 KGTEINTGVVVKKLSEILQARGKKGTDRAAQIELLHALAGIAAENNLGEGILVKIKFNIIASLYD 384

  Fly   364 YNQKISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYATS--PFYVRGCPLAAVE 426
            ||..::..||.:.|...|:.:..::.:|..|.:|.:.|::||:.|..|.|  ||.||||.|..||
Zfish   385 YNPNLAAFMKADMWKKCLDCIDELLDILFNNNNIFIGENIAEDSENLAISDQPFRVRGCILTLVE 449

  Fly   427 RLDDEFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKF 491
            |:|:||.|:::..||||.:||..||||..|...|:.:|||.|..|:..|.||:|||:|.|.||||
Zfish   450 RMDEEFTKIMQNTDPHSQEYVDNLKDEGRVCGIIDRLLQYLETKGSTEEVCRVYLRRIMHTYYKF 514

  Fly   492 DPEVLKKKRGELPATTSTSVD-----------VMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMH 545
            |.:..::..| |...|.:..|           :||:|||||||||.||||||.|||.||||||:|
Zfish   515 DYKAHRRSLG-LQGETKSEQDQEESEGDDSAIIMDRLCKFIYAKDRTDRIRTCAILCHIYHHALH 578

  Fly   546 DNWFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKE 610
            ..|:|||||:|||||||||..|||..:|||||.|..||:||||||.:||||:.|:|:..:|:.||
Zfish   579 SRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGMIKDAHNALLDIQSSGRAKE 643

  Fly   611 LLAQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRM 675
            ||.||||.:...||:||||||||:||:||||||||||||||||||||||||||:|||||||||||
Zfish   644 LLGQGLLMRNMQERNAEQEKIEKRRQVPFHMHINLELLECVYLVSAMLLEIPYMAAHEFDARRRM 708

  Fly   676 ISKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDR 740
            |||.|:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||:||||||.|:..
Zfish   709 ISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWRTCHSFIINEKMNSKVWDLFPEAKC 773

  Fly   741 VREMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPS 805
            |||||.:.|:||||||||||||:||.|||:.:|::|:||.:|.|||||||||||||||||||.|:
Zfish   774 VREMLVRKIQEESLRTYLFTYSSVYDSISMETLSEMFELELPTVHSIISKMIINEELMASLDQPT 838

  Fly   806 ETVGMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQ---GNFFQRGNMGNRGDRGYNRNQNN 867
            :||.|||:||:.||.:|:|..:|:..||:.||:|||:||   |.:|.|...|     ||.:.|..
Zfish   839 QTVVMHRTEPTSLQNMALQLAEKLGGLVENNERVFDLKQGVYGGYFNRDQKG-----GYQQKQGY 898

  Fly   868 QGGNWLGQRRDRNNRNRNQRGHHKNNQDRQQQQQQQVQ 905
            |.|     ..|:....:.::|:.:|:|....||:|..|
Zfish   899 QRG-----APDQRGGYQQKQGYQRNDQKGGYQQKQNYQ 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_001286545.1	eIF-3c_N	24..671	CDD:283193	342/681 (50%)
eIF3c	NP_001286545.1	PAM	744..823	CDD:214803	54/78 (69%)
eif3c	XP_005156056.1	eIF-3c_N	31..704	CDD:283193	342/679 (50%)
		PAM	777..862	CDD:214803	56/84 (67%)
		eIF-3_zeta	888..>939	CDD:282888	14/54 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582197
Domainoid	1	1.000	637	1.000	Domainoid score	I159
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2781
Inparanoid	1	1.050	904	1.000	Inparanoid score	I363
OMA	1	1.010	-	-		QHG54519
OrthoDB	1	1.010	-	-		D120738at33208
OrthoFinder	1	1.000	-	-		FOG0003671
OrthoInspector	1	1.000	-	-		oto38721
orthoMCL	1	0.900	-	-		OOG6_101999
Panther	1	1.100	-	-	LDO	PTHR13937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R378
SonicParanoid	1	1.000	-	-		X2545
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900